m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0176)
| Name |
Celastrol
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| Synonyms |
Tripterin; Tripterine; Celastrol, Celastrus scandens; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid
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| Structure |
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3D MOL
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| Formula |
C29H38O4
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| InChI |
1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
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| InChIKey |
KQJSQWZMSAGSHN-JJWQIEBTSA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 4 item(s) under this drug | ||
| Crosstalk ID: M6ACROT02122 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Claspin (CLSPN) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |
| Crosstalk ID: M6ACROT02123 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Apoptosis regulator Bcl-2 (BCL2) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |
| Crosstalk ID: M6ACROT02131 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Claspin (CLSPN) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |
| Crosstalk ID: M6ACROT02132 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Apoptosis regulator Bcl-2 (BCL2) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |