m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0160)
| Name |
VS-6063
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| Synonyms |
Defactinib hydrochloride; 1073160-26-5; Defactinib (hydrochloride); UNII-L2S469LM49; Defactinib hydrochloride [USAN]; L2S469LM49; Defactinib hydrochloride (USAN); Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-, hydrochloride; Defactinib HCl; Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)-2-pyrazinyl)methyl)amino)-5-(trifluoromethyl)-2-pyrimidinyl)amino)-, hydrochloride (1:1); Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsu
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| Structure |
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3D MOL
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| Formula |
C20H21F3N8O3S
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| InChI |
1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)
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| InChIKey |
FWLMVFUGMHIOAA-UHFFFAOYSA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 3 item(s) under this drug | ||
| Crosstalk ID: M6ACROT00131 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Interferon-inducible protein 4 (ADAR1) | |
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Protein tyrosine kinase 2 (PTK2) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT05244 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Prolyl endopeptidase FAP (FAP) | |
| Epigenetic Regulator | hsa-miR-607 | |
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Non-small cell lung cancer | |
| Crosstalk ID: M6ACROT05258 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Prolyl endopeptidase FAP (FAP) | |
| Epigenetic Regulator | hsa_circ_0072309 (Circ_LIFR) | |
| Regulated Target | hsa-miR-607 | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Non-small cell lung cancer | |