General Information of the Drug (ID: M6ADRUG0132)
Name
Mitoxantrone
Synonyms
DHAD; DHAQ; Dihydroxyanthraquinone; MIX; Misostol; Mitoxanthrone; Mitoxantron; Mitoxantrona; Mitoxantronum; Mitozantrone; DHAQ HCl; Mitoxantrone [INN]; Mitozantrone hydrochloride; Mitoxantrone 2HCl; Liposome Encapsulated Mitoxantrone (LEM); Misostol (TN); Mitoxantrona [INN-Spanish]; Mitoxantrone (INN); Mitoxantrone (free base); Mitoxantronum [INN-Latin]; Novantrone (TN); AN-584/42007670; Novantrone(R) (mitoxantrone for injection concentrate); DHAQ (*Diacetate salt*); MITOXANTRONE, Mitoxantrone Hydrochloride, Mitoxantrone dihydrochloride, MITOXANTHRONE HYDROCHLORIDE; MITOXANTRONE, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)ANTHRA-9,10-QUINONE; 1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone; 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE; 1,4-Dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione; 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon; 1,4-Dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthra-9,10-quinone; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione; 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone; 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-(9CI)
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Structure
3D MOL
Formula
C22H28N4O6
InChI
1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
InChIKey
KKZJGLLVHKMTCM-UHFFFAOYSA-N
PubChem CID
4212
TTD Drug ID
D0R3JB
DrugBank ID
DB01204
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
In total 3 item(s) under this drug
Crosstalk ID: M6ACROT05659
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
m6A Target RNA component of 7SK nuclear ribonucleoprotein (RN7SK)
Epigenetic Regulator RNA component of 7SK nuclear ribonucleoprotein (RN7SK)
Regulated Target Cullin 1 (CUL1)
Crosstalk relationship m6A → ncRNA
Crosstalk ID: M6ACROT05660
m6A Regulator Methyltransferase-like 3 (METTL3)
m6A Target RNA component of 7SK nuclear ribonucleoprotein (RN7SK)
Epigenetic Regulator RNA component of 7SK nuclear ribonucleoprotein (RN7SK)
Regulated Target Cullin 1 (CUL1)
Crosstalk relationship m6A → ncRNA
Crosstalk ID: M6ACROT05661
m6A Regulator YTH domain-containing protein 2 (YTHDC2)
m6A Target RNA component of 7SK nuclear ribonucleoprotein (RN7SK)
Epigenetic Regulator RNA component of 7SK nuclear ribonucleoprotein (RN7SK)
Regulated Target Cullin 1 (CUL1)
Crosstalk relationship m6A → ncRNA
References
Ref 1 US patent application no. 6,187,586, Antisense modulation of AKT-3 expression.