m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0123)
| Name |
Raltitrexed
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| Synonyms |
Tomudex; 112887-68-0; ZD1694; ZD-1694; ICI-D1694; D-1694; ZD 1694; ICI D1694; UNII-FCB9EGG971; D1694; D 1694; CHEBI:5847; Raltitrexed (Tomudex); C21H22N4O6S; ZD-16; (2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid; FCB9EGG971; CHEMBL225071; N-(5-(N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid; ICI-D-1694; NSC-639186; NCGC00229704-01; DSSTox_RID_81653; DSSTox_CID_26482; DSSTox_GSID_46482
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| Structure |
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3D MOL
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| Formula |
C21H22N4O6S
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| InChI |
1S/C21H22N4O6S/c1-11-22-14-4-3-12(9-13(14)19(28)23-11)10-25(2)17-7-6-16(32-17)20(29)24-15(21(30)31)5-8-18(26)27/h3-4,6-7,9,15H,5,8,10H2,1-2H3,(H,24,29)(H,26,27)(H,30,31)(H,22,23,28)/t15-/m0/s1
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| InChIKey |
IVTVGDXNLFLDRM-HNNXBMFYSA-N
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Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 3 item(s) under this drug | ||
| Crosstalk ID: M6ACROT06032 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | |
| m6A Target | RNA component of 7SK nuclear ribonucleoprotein (RN7SK) | |
| Epigenetic Regulator | RNA component of 7SK nuclear ribonucleoprotein (RN7SK) | |
| Regulated Target | Cullin 1 (CUL1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT06033 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | RNA component of 7SK nuclear ribonucleoprotein (RN7SK) | |
| Epigenetic Regulator | RNA component of 7SK nuclear ribonucleoprotein (RN7SK) | |
| Regulated Target | Cullin 1 (CUL1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT06034 | ||
| m6A Regulator | YTH domain-containing protein 2 (YTHDC2) | |
| m6A Target | RNA component of 7SK nuclear ribonucleoprotein (RN7SK) | |
| Epigenetic Regulator | RNA component of 7SK nuclear ribonucleoprotein (RN7SK) | |
| Regulated Target | Cullin 1 (CUL1) | |
| Crosstalk relationship | m6A → ncRNA | |