m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0335)
Name
Hepatic inflammation
ICD
ICD-11: DB97
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 3 item(s) under this disease
Crosstalk ID: M6ACROT02113
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
 Target Gene 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02114
 Crosstalk Info 
m6A Regulator Methyltransferase-like 14 (METTL14)
 Regulator Info 
m6A Target Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
 Target Gene 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02115
 Crosstalk Info 
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
 Regulator Info 
m6A Target Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
 Target Gene 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)
Crosstalk relationship DNA modification → m6A
References
Ref 1 AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27. doi: 10.1158/1535-7163.MCT-12-1174. Epub 2013 Jul 16.