m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0172)
| Name |
Psoriasis
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|---|---|---|---|---|---|
| ICD |
ICD-11: EA90
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Full List of Target Gene(s) of This m6A-centered Disease Response
LOC10013.776 (AGAP2-AS1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [3] | |||
| Response Summary | METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. LOC10013.776 (AGAP2-AS1) is upregulated in the skin tissue of psoriasis patients and m6A methylation was involved in its upregulation. | |||
| Responsed Disease | Psoriasis [ICD-11: EA90] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | mTOR signaling pathway | hsa04150 | ||
| PI3K-Akt signaling pathway | hsa04151), | |||
| Cell Process | Cell proliferation | |||
| In-vitro Model | HaCaT | Normal | Homo sapiens | CVCL_0038 |
| NHEK (Normal human epithelial keratinocytes) | ||||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 2 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05123 | ||
| m6A Regulator | Methyltransferase-like 14 (METTL14) | |
| m6A Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Epigenetic Regulator | Urothelial cancer associated 1 (UCA1) | |
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | |
| Crosstalk relationship | ncRNA → m6A | |
| Crosstalk ID: M6ACROT05560 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | LOC10013.776 (AGAP2-AS1) | |
| Epigenetic Regulator | LOC10013.776 (AGAP2-AS1) | |
| Regulated Target | hsa-miR-424-5p | |
| Crosstalk relationship | m6A → ncRNA | |
References