m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00788)

Target Name	LOC10013.776 (AGAP2-AS1)
Synonyms	LOC10013.776; PUNISHER Click to Show/Hide
Gene Name	AGAP2-AS1
Chromosomal Location	12q14.1
Gene ID	100130776
HGNC ID	HGNC:48633

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

AGAP2-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RIP-seq result supporting the interaction between AGAP2-AS1 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 6.67E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. LOC10013.776 (AGAP2-AS1) is upregulated in the skin tissue of psoriasis patients and m6A methylation was involved in its upregulation.
Target Regulation	Up regulation
Responsed Disease	Psoriasis		ICD-11: EA90	Disease Info
Pathway Response	mTOR signaling pathway			hsa04150
	PI3K-Akt signaling pathway			hsa04151),
Cell Process	Cell proliferation
In-vitro Model	HaCaT	Normal	Homo sapiens	CVCL_0038
	NHEK (Normal human epithelial keratinocytes)

Psoriasis [ICD-11: EA90]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. LOC10013.776 (AGAP2-AS1) is upregulated in the skin tissue of psoriasis patients and m6A methylation was involved in its upregulation.
Responsed Disease	Psoriasis [ICD-11: EA90]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	mTOR signaling pathway			hsa04150
	PI3K-Akt signaling pathway			hsa04151),
Cell Process	Cell proliferation
In-vitro Model	HaCaT	Normal	Homo sapiens	CVCL_0038
	NHEK (Normal human epithelial keratinocytes)

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05560		Crosstalk Info
Epigenetic Regulator	LOC10013.776 (AGAP2-AS1)
Regulated Target	hsa-miR-424-5p
Crosstalk relationship	m6A → ncRNA
Disease	Psoriasis	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00788)

LOC10013.776 (AGAP2-AS1)

N6-methyladenosine (m6A)

In total 25 m6A sequence/site(s) in this target gene
mod ID: M6ASITE013622		Click to Show/Hide the Full List
mod site	chr12:57726282-57726283:+		[2]
Sequence	GGGGACCTCCCCTTCCGCGAACCCCGAGCGGGTAGACCCAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; U2OS; H1A; H1B; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; TIME; TREX; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195647
mod ID: M6ASITE013623		Click to Show/Hide the Full List
mod site	chr12:57726297-57726298:+		[2]
Sequence	CGCGAACCCCGAGCGGGTAGACCCAGAGCAATCCGAGTGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; U2OS; H1A; H1B; GM12878; LCLs; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; TIME; TREX; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195648
mod ID: M6ASITE013624		Click to Show/Hide the Full List
mod site	chr12:57726321-57726322:+		[2]
Sequence	AGAGCAATCCGAGTGTGGAAACAATGGAGAGGGGGCGTGTT
Motif Score	2.20572619
Cell/Tissue List	HeLa; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195649
mod ID: M6ASITE013625		Click to Show/Hide the Full List
mod site	chr12:57727182-57727183:+		[2]
Sequence	GGTGCTCAGCGGCGCCAGGAACAGTAGCTGCTCGTACTTGG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195657
mod ID: M6ASITE013626		Click to Show/Hide the Full List
mod site	chr12:57727236-57727237:+		[2]
Sequence	CTCGCGCTCCTCCCTGCAAGACCAGGGATCAACGGAAAAGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195658
mod ID: M6ASITE013627		Click to Show/Hide the Full List
mod site	chr12:57727247-57727248:+		[3]
Sequence	CCCTGCAAGACCAGGGATCAACGGAAAAGGCTCTAGGGACC
Motif Score	2.147845238
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195659
mod ID: M6ASITE013628		Click to Show/Hide the Full List
mod site	chr12:57727265-57727266:+		[2]
Sequence	CAACGGAAAAGGCTCTAGGGACCCCCAGCCAGGACTTCTGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195660
mod ID: M6ASITE013629		Click to Show/Hide the Full List
mod site	chr12:57727278-57727279:+		[2]
Sequence	TCTAGGGACCCCCAGCCAGGACTTCTGCCCCTACCCACGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195661
mod ID: M6ASITE013630		Click to Show/Hide the Full List
mod site	chr12:57727299-57727300:+		[2]
Sequence	CTTCTGCCCCTACCCACGGGACCGTCTCAGGTTCGCACACC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; GSC-11; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195662
mod ID: M6ASITE013631		Click to Show/Hide the Full List
mod site	chr12:57727498-57727499:+		[2]
Sequence	GTCCAGCGAGCGAACGCGGGACAGGTGTGTGCCCAGGTTGC
Motif Score	3.643047619
Cell/Tissue List	HeLa; A549; HEK293T; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195666
mod ID: M6ASITE013632		Click to Show/Hide the Full List
mod site	chr12:57727532-57727533:+		[2]
Sequence	AGGTTGCGGTGGATGCCAGAACACTCGATGCAGATGAGGGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; A549; GSC-11; HEK293T; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195667
mod ID: M6ASITE013633		Click to Show/Hide the Full List
mod site	chr12:57727643-57727644:+		[4]
Sequence	CAGGCACCCCGGCATTCACTACACTCCCTAGCCCCTCCGCT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195669
mod ID: M6ASITE013634		Click to Show/Hide the Full List
mod site	chr12:57727829-57727830:+		[2]
Sequence	AAGCCCCACCTCCTTCTCAGACACCTCTGCTCTCCTCTCAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195672
mod ID: M6ASITE013635		Click to Show/Hide the Full List
mod site	chr12:57727886-57727887:+		[5]
Sequence	CGTTGCCAATGGCCGTCAGCACCAGGGTCAGTTCCTGCGGC
Motif Score	2.809946429
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195673
mod ID: M6ASITE013636		Click to Show/Hide the Full List
mod site	chr12:57727916-57727917:+		[5]
Sequence	GTTCCTGCGGCCAGTCCTCCACTCCACCTCAAACTCTTACC
Motif Score	2.475107143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195674
mod ID: M6ASITE013637		Click to Show/Hide the Full List
mod site	chr12:57727928-57727929:+		[2]
Sequence	AGTCCTCCACTCCACCTCAAACTCTTACCTTGACCTTGCTG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195675
mod ID: M6ASITE013638		Click to Show/Hide the Full List
mod site	chr12:57727966-57727967:+		[2]
Sequence	CTGCTCTCACAGCATTGCAGACTGGCTAGGATCTGACTCTC
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195676
mod ID: M6ASITE013639		Click to Show/Hide the Full List
mod site	chr12:57727981-57727982:+		[3]
Sequence	TGCAGACTGGCTAGGATCTGACTCTCGATGGCCTGGACCCA
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195677
mod ID: M6ASITE013640		Click to Show/Hide the Full List
mod site	chr12:57727997-57727998:+		[2]
Sequence	TCTGACTCTCGATGGCCTGGACCCAGGCATCCCGCTCCTCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195678
mod ID: M6ASITE013641		Click to Show/Hide the Full List
mod site	chr12:57728020-57728021:+		[2]
Sequence	CAGGCATCCCGCTCCTCAAAACTGGCTGCCTCAAAGTGCCA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195679
mod ID: M6ASITE013642		Click to Show/Hide the Full List
mod site	chr12:57728058-57728059:+		[2]
Sequence	CCACGTCTGACCCGTGCTGGACACGATCAGGAACTCAAAGT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195680
mod ID: M6ASITE013643		Click to Show/Hide the Full List
mod site	chr12:57728070-57728071:+		[2]
Sequence	CGTGCTGGACACGATCAGGAACTCAAAGTTTTCCTCTGAGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195681
mod ID: M6ASITE013644		Click to Show/Hide the Full List
mod site	chr12:57728117-57728118:+		[2]
Sequence	TGGGATGGGGTCATTAAGGGACAGAGTTCAAGCAGGGGCTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; H1A; H1B; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195683
mod ID: M6ASITE013645		Click to Show/Hide the Full List
mod site	chr12:57728149-57728150:+		[2]
Sequence	CAGGGGCTGCCTTTCCCAAGACCGTCCTCCCTGATGTCCAT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; fibroblasts; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195684
mod ID: M6ASITE013646		Click to Show/Hide the Full List
mod site	chr12:57728339-57728340:+		[2]
Sequence	GCTTTATAAATATTTCTTAAACTACCAAAGGATTTTAGTTT
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; GSC-11; iSLK; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000542466.2
External Link	RMBase: m6A_site_195685

Ref 1	N(6)-methyladenosine-modified long non-coding RNA AGAP2-AS1 promotes psoriasis pathogenesis via miR-424-5p/AKT3 axis. J Dermatol Sci. 2022 Jan;105(1):27-36. doi: 10.1016/j.jdermsci.2021.11.007. Epub 2021 Nov 18.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 4	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 5	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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