m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05123
 [1]
Non-coding RNA UCA1 METTL14  lncRNA       miRNA   circRNA Direct Inhibition m6A modification HIF1A HIF1A METTL14 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
m6A Target Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Urothelial cancer associated 1 (UCA1) LncRNA View Details
Regulated Target Methyltransferase-like protein 14 (METTL14) View Details
Crosstalk Relationship ncRNA  →  m6A Inhibition
Crosstalk Mechanism ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A)/NF-kappaB axis in psoriasis
Responsed Disease Psoriasis ICD-11: EA90
 Disease Info 
In-vitro Model
 HaCaT Normal Homo sapiens CVCL_0038
HUVEC-C Normal Homo sapiens CVCL_2959
HEK293 Normal Homo sapiens CVCL_0045
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) 21 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PT2385 Phase 2 [2]
Synonyms
ONBSHRSJOPSEGS-INIZCTEOSA-N; PT-2385; UNII-6O16716DXP; 1672665-49-4; 6O16716DXP; SCHEMBL16555810; ZINC230453533; AKOS030526641; HY-12867; PT2385,1672665-49-4, PT 2385,PT-2385; Benzonitrile, 3-(((1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl)oxy)-5-fluoro-; 3-{[(1s)-2,2-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile; 3-(((1S)-2,2-Difluoro-1-hydroxy-7-methanesulfonyl-2,3-dihydro-1hinden-4-yl)oxy)-5-fluorobenzonitrile; 79A
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MOA Inhibitor
External Link
CID: 91754484
TTD: D0C9PZ
 Compound Name ISIS 298697 Investigative [3]
External Link
TTD: D00JHE
 Compound Name ISIS 298744 Investigative [3]
External Link
TTD: D01DDQ
 Compound Name ISIS 298746 Investigative [3]
External Link
TTD: D01ZCK
 Compound Name ISIS 298745 Investigative [3]
External Link
TTD: D07GVC
 Compound Name ISIS 298743 Investigative [3]
External Link
TTD: D09DCJ
 Compound Name ISIS 298702 Investigative [3]
External Link
TTD: D0B5LQ
 Compound Name ISIS 298700 Investigative [3]
External Link
TTD: D0C2IG
 Compound Name ISIS 175510 Investigative [3]
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TTD: D0G9BP
 Compound Name ISIS 298699 Investigative [3]
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TTD: D0L5ME
 Compound Name ISIS 298712 Investigative [3]
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TTD: D0L9KW
 Compound Name ISIS 298711 Investigative [3]
External Link
TTD: D0SN5O
 Compound Name ISIS 298701 Investigative [3]
External Link
TTD: D0X8GB
 Compound Name (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol Investigative [4]
Synonyms
Lificiguat; yc-1; 170632-47-0; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole; YC 1; UNII-515CC1WPTE; Lificiguat(YC-1); 154453-18-6; [5-(1-benzyl-1h-indazol-3-yl)-2-furyl]methanol; 515CC1WPTE; CHEMBL333985; OQQVFCKUDYMWGV-UHFFFAOYSA-N; C19H16N2O2; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole; 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole; [5-(1-benzyl-1H-indazol-3-yl)furan-2-yl]methanol; 5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
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MOA Inhibitor
External Link
CID: 5712
TTD: D00REK
 Compound Name HIF-1alpha Phase 4 [5]
Synonyms
Unii-NA856793UT; 192705-79-6; PD-166866; PD166866; PD 166866; CHEMBL299763; NA856793UT; 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea; 1-(2-Amino-6-(3,5-dimethoxyphenyl)-pyrido(2,3-d)pyrimidin-7-yl)-3-tert-butyl urea; Urea,N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-; 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea; 6-arylpyrido[2,3-d]pyrimidine deriv 25; AC1NS3U5; SCHEMBL1248489; BDBM3443; CTK4E1060
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External Link
CID: 5328127
TTD: D0B0AX
 Compound Name IT-101 Phase 3 [5]
External Link
TTD: D06PEW
 Compound Name 2-Methoxyestradiol Phase 2 [5]
Synonyms
ESM; Panzem; PulmoLAR; Panzem NCD; M 6383; (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol; (17beta)-2-methoxyestra-1(10),2,4-triene-3,17-diol; (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER; 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether; 2,3,17beta-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether; 2-Hydroxyestradiol 2-methyl ether; 2-Hydroxyestradol 2-methyl ether; 2-ME2, 2-Methoxyestradiol; 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol; 2-Methoxyestradiol-17beta; 3,17beta-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
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External Link
CID: 66414
TTD: D06NYA
DrugBank: DB02342
 Compound Name PX-478 Phase 1 [5]
Synonyms
685898-44-6; PX-478 2HCl; UNII-T23U22X160; PX478; PX 478; Melphalan N-Oxide Impurity HCl; T23U22X160; 4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine; PX-478 dihydrochloride; SCHEMBL18548830; C13H18Cl2N2O3.2ClH; DTXSID00218688; MolPort-035-789-733; 2675AH; s7612; 2-Amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide; AKOS030231369; CS-5164; HY-10231; KB-80169; Z-3209; L-Phenylalanine, 4-(bis(2-chloroethyl)oxidoamino)-, dihydrochloride; (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide di
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External Link
CID: 11234794
TTD: D06ZVO
DrugBank: DB06082
 Compound Name EZN-2968 Phase 1 [5]
External Link
TTD: D0NF5J
 Compound Name ENMD-1198 Phase 1 [5]
Synonyms
EM-5171; EM-883; EM-900; Hypoxia inducible factor 1 inhibitors, EntreMed; HIF-1 inhibitors, EntreMed; HIF-1 inhibitors (cancer), EntreMed; 2-ME2 analogs (oral, cancer), EntreMed; 2-methoxyestradiol analogs (oral, cancer), EntreMed
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External Link
CID: 11483754
TTD: D0Y5QD
DrugBank: DB05959
 Compound Name Pyrrolidine carboxamide derivative 1 Patented [5]
Synonyms
PMID26882240-Compound-22
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External Link
CID: 56684144
TTD: D0Q2SE
EA90: Psoriasis 166 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Teriparatide Discontinued in Phase 2 [6]
Synonyms
Forteo; Forteo (TN); Teriparatide (genetical recombination); Teriparatide (USAN/INN); Teriparatide (genetical recombination) (JAN)
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External Link
CID: 16133850
TTD: D0YA2L
 Compound Name Ponesimod Phase 2 [7]
Synonyms
854107-55-4; UNII-5G7AKV2MKP; 5G7AKV2MKP; CHEMBL1096146; Ponesimod [USAN:INN]; Ponesimod,ACT-128800; Ponesimod (ACT-128800); GTPL9320; SCHEMBL15477937; SCHEMBL15477934; DTXSID50234631; MolPort-035-681-391; MolPort-046-033-541; EX-A1417; ZINC34509627; s8241; BDBM50316768; AKOS022180266; DB12016; Compound 8bo [PMID:20446681]; HY-10569; KB-72962; AS-35140; AJ-89002; (2Z,5Z)-5-(3-Chloro-4-((2R)-2,3-dihydroxypropoxy)phenylmethylidene)-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-
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External Link
CID: 11363176
TTD: D0Y4SI
DrugBank: DB12016
 Compound Name Spesolimab Approved [8]
External Link
TTD: D0W9YW
 Compound Name Lestaurtinib Approved (orphan drug) [9]
Synonyms
A 1544750; CEP 701; KT 5555; KT5555; SP 924; CEP-701; KT-5555; SPM-924; Lestaurtinib (USAN/INN)
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External Link
CID: 126565
TTD: D0V9WF
DrugBank: DB06469
 Compound Name Belumosudil Approved [10]
External Link
CID: 11950170
TTD: D0U5UC
 Compound Name Deucravacitinib Approved [11]
External Link
CID: 134821691
TTD: D0S1XX
 Compound Name Dithranol Approved [12]
Synonyms
Anthralin; Micanol; Dithranol cream (Crystalip); Dithranol cream (Crystalip), Bioglan
    Click to Show/Hide
External Link
CID: 2202
TTD: D0QO7H
DrugBank: DB11157
 Compound Name Ciclosporin Approved [13]
Synonyms
Cyclosporine A; CSA; Antibiotic S 7481F1; BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA; BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA; C 3662; CB-01-09 MMX; CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)); Cicloral (TN); Ciclosporin (JP15); Cipol N; Cipol-N; Consupren; Consupren S; CsA & IFN-alpha; Cyclokat; Cyclophorine; Cyclosporin; Cyclosporin A; Cyclosporin A & IFN-alpha; Cyclosporin A Implant; Cyclosporin A, Tolypocladium inflatum; Cyclosporine (USP); Cyclosporine [USAN]; DE-076; Equoral; From Tolypocladium inflatum (Trichoderma polysporin); GNF-Pf-2808; Gengraf; Gengraf (TN); Helv Chim Acta 60: 1568 (1977); Mitogard; Modusik-A; Neoplanta; Neoral; Neoral (TN); NeuroSTAT; Nova-22007; OL 27-400; OL-27400; OLO-400; Papilock; Pulminiq; RamihyphinA; Restasis; Restasis (TN); S-Neoral; SDZ-OXL 400; ST-603; Sandimmun; Sandimmun Neoral; Sandimmune; Sandimmune (TN); Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine; Sang-2000; Sang-35; SangCyA; Sigmasporin; Sigmasporin Microoral; TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A); Vekacia; Zyclorin
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External Link
CID: 24883466
TTD: D0O3YF
 Compound Name Xp-828l Approved [12]
Synonyms
Dermylex (TN)
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External Link
TTD: D0N1NE
 Compound Name Voclosporin Phase 3 [14]
Synonyms
Luveniq; ISAtx-247; ISA-247; UNII-2PN063X6B1; ISATX247; 515814-01-4; ISA247; 2PN063X6B1; ISA 247; trans-ISA-247; LX211; Voclosporin (USAN/INN); Voclosporin [USAN:INN]; Voclera; 3odi; LX-211; LX-214; ISA247, Luveniq; AC1OCFHS; R-1524; SCHEMBL12632344; CHEBI:135957; (E)-ISA-247; DB11693; 515814-00-3; HY-106638; CS-0026210; D09033; Cyclosporin A, 6-((2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid)-; 368455-04-3; Voclosporin [USAN]; R 1524; Trans-ISA 247; TrkA-IgG
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External Link
CID: 6918486
TTD: D0L9HX
DrugBank: DB11693
 Compound Name Verteporfin Approved [12]
Synonyms
Visudyne (TN)
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External Link
CID: 11980904
TTD: D0I3XG
 Compound Name Mirikizumab Approved [10]
External Link
TTD: D0E7QB
 Compound Name Tazarotene Approved [15]
Synonyms
Avage; Suretin; Tazaroteno; Tazarotenum; Tazorac; Tazoral; Zorac; AGN 190168; AGN-190168; Avage (TN); Tazarotene [USAN:INN]; Tazorac (TN); Zorac (TN); Tazarotene (JAN/USAN/INN); Tazorac, Avage, Zora, Tazarotene; Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate; Ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-,ethyl ester
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External Link
CID: 5381
TTD: D0BM5G
DrugBank: DB00799
 Compound Name Ustekinumab Phase 3 [16]
Synonyms
6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine; WR99210; WR-99210; 47326-86-3; BRN 0629517; WR 99210; 1,3,5-Triazine-2,4-diamine, 1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-; WR-99,210; CHEMBL129788; BRL 6231; 1,6-Dihydro-6,6-dimethyl-1-(3-(2,4,5-trichlorophenoxy)-propoxy)-1,3,5-triazine-2 ,4-diamine; 1-(2',4',5'-Trichlorophenoxypropoxy)-1,2-dihydro-2,2-dimethyl-4,6-diamino-s-triazine; Stelara (TN)
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External Link
TTD: D0A2UV
 Compound Name Azaribine Approved [12]
Synonyms
Triazure; Triacetyl-6-azauridine; Azaribinum; Azaribina; 2169-64-4; 6-Azaribine; TA-Azur; Azaribin; 2',3',5'-Tri-O-acetyl-6-azauridine; 6-Azauridine triacetate; 6-Azauridin-triacetat; 6-Azauridine 2',3',5'-triacetate; Azaribinum [INN-Latin]; 6-AzUR-TA; Azaribina [INN-Spanish]; 2',3',5'-Triacetyl-6-azauridine; CB-304; UNII-K1U80DO9EB; 6-Azauracilribosid-triacetat; K1U80DO9EB; Azaribine [USAN:INN:BAN]; MLS000069488; EINECS 218-515-6; Azauridine triacetate; 2-beta-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione 2',3',5'-triace
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CID: 16574
TTD: D09SIK
 Compound Name Ammoniated mercury Approved [12]
Synonyms
White precipitate; Mercuric chloride, ammoniated; Mercury ammoniated; Ammoniated mercuric chloride; Mercury, ammoniated; Aminomercury chloride; Aminomercuric chloride; Hydrargyrum ammoniatum; Mercury amine chloride; MERCURIC AMMONIUM CHLORIDE; White mercuric precipitate; White mercury precipitated; Quecksilber(II)-amid-chlorid; Hydrargyrum precipitatum album; Hydrargyrum praecipitatum album; UNII-JD546Z56F0; Mercury(II) chloride ammonobasic; Mercury, ammonobasic (HgNH2Cl); HSDB 1175; JD546Z56F0; EINECS 233-3
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CID: 3032553
TTD: D08YPZ
DrugBank: DB13344
 Compound Name Tacalcitol Approved [17]
Synonyms
Bonalfa (TN)
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External Link
CID: 5283734
TTD: D08SVH
DrugBank: DB13689
 Compound Name Methoxsalen Approved [18]
Synonyms
Ammodin; Ammoidin; Deltasoralen; Dermox; Geroxalen; Meladinin; Meladinina; Meladinine; Meladoxen; Meloxine; Methoxalen; Methoxaten; Oxoralen; Oxsoralen; Oxypsoralen; Puvalen; Puvamet; Ultramop; Uvadex; XANTHOTOXIN; Xanthotoxine; Zanthotoxin; Boehringer Ingelheim Brand of Methoxsalen; Canderm Brand of Methoxsalen; Chinoin Brand of Methoxsalen; DB Brand of Methoxsalen; Delta Brand of Methoxsalen; Dermatech Brand of Methoxsalen; Galderma Brand of Methoxsalen; Methoxa Dome; Methoxsalen Canderm Brand; Methoxsalen Chinoin Brand; Methoxsalen Delta Brand; Methoxsalen Dermatech Brand; Methoxsalen plus ultraviolet radiation; Mex America Brand of Methoxsalen; Oxsoralen Ul tra; Oxsoralen Ultra; Oxsoralen lotion; Sanofi Synthelabo Brand of Methoxsalen; Ultra Mop; Ultramop Lotion; ICN Brand 1 of Methoxsalen; ICN Brand 2 of Methoxsalen; ICN Brand 3 of Methoxsalen; X0009; An 8-methoxyfurocoumarin; Meladinin (VAN); Methoxa-Dome; Methoxsalen Mex-America Brand; Methoxsalen Sanofi-Synthelabo Brand; Methoxsalen [BAN:JAN]; Methoxsalen with ultra-violet A theraphy; Mex-America Brand of Methoxsalen; New-Meladinin; O-methylxanthotoxol; OXSORALEN (TN); Oxsoralen-ultra; Proralone-mop; Psoralen-mop; Psoralon-MOP; Sanofi-Synthelabo Brand of Methoxsalen; Methoxsalen (JP15/USP); Methoxy-8-psoralen; 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, .delta.-lactone; 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone; 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone; 7-Furocoumarin; 8 Methoxypsoralen; 8-METHOXYPSORALEN + UVA (SEE ALSO C55903); 8-MOP; 8-Methoxy; 8-Methoxy(furano-3'.2':6.7-coumarin); 8-Methoxy-(furano-3'.2':6.7-coumarin); 8-Methoxy-2',3',6,7-furocoumarin; 8-Methoxy-4',5',6,7-furocoumarin; 8-Methoxy-4',5':6,7-furocoumarin; 8-Methoxy-[furano-3'.2':6.7-coumarin]; 8-Methoxyfuranocoumarin; 8-Methoxypsoralen; 8-Methoxypsoralen with ultraviolet A therapy; 8-Methoxypsoralene; 8-methoxyfuranocoumarins; 8-methoxyfurocoumarins; 8MO; 8MOP; 9-(methyloxy)-7H-furo[3,2-g]chromen-7-one; 9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; 9-Methoxy-7H-furo(3,2-g)benzopyran-7-one; 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one; 9-Methoxy-7H-furo[3,2-g]chromen-7-one; 9-Methoxyfuro(3,2-g)chromen-7-one; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; 9-Methoxypsoralen; 9-metho xy-7H-furo(3,2-g)benzopyran-7-one; 9-methoxyfuro[3,2-g]chromen-7-one
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CID: 4114
TTD: D08SKH
DrugBank: DB00553
 Compound Name Valrubicin Approved [12]
Synonyms
Valstar; Valrubicin [USAN]; Valstar Preservative Free; AD 32; Antibiotic AD 32; Valstar (TN); N-Trifluoroacetyladriamycin 14-valerate; N-Trifluoroacetyldoxorubicin 14-valerate; Trifluoroacetyladriamycin-14-valerate; Valrubicin (USP/INN); N-Trifluoroacetyladriamycin-14-valerate; Adriamycin, trifluoroacetyl-, 14-valerate; [2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate; (2S-cis)-2-(1,2,3,4,6,11-Hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-lyxo-hexopyranosyl)oxy)-2-naphthacenyl)-2-oxoethyl pentanoate; (2S-cis)-Pentanoic acid, 2-(1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-lyxo-hexopyranosyl)oxy)-2-naphth acenyl)-2-oxoethyl ester; (8S,10S)-8-Glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-alpha-L-lyxo-hexopyranosyl)oxy)-5,12-naphthacenedione 8(sup 2)-valerate; Pentanoic acid, 2-((2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetylamino)-, alpha-L-lysohexopyranoxyl)oxy)-2-naphthacenyl)-2-oxoethyl ester
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CID: 454216
TTD: D07IPB
DrugBank: DB00385
 Compound Name Apremilast Approved [19]
Synonyms
Apremilast (USAN); CC-10004; N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
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CID: 11561674
TTD: D07ESC
DrugBank: DB05676
 Compound Name Acitretin Approved [20]
Synonyms
Acitretina; Acitretine; Acitretinum; Etretin; Isoacitretin; Isoetretin; Neotigason; Soriatane; TMMP; Acitretina [Spanish]; Acitretine [French]; Acitretinum [Latin]; Retinoid etretin; U0279; Ro 10-1670; Ro 13-7652; Soriatane (TN); Soriatane, Acitretin; Acitretin (USAN/INN); Acitretin [USAN:INN:BAN]; All-trans-Acitretin; Ro 10-1670/000; Ro-10-1670; Ro-13-7652; Ro-10-1670/000; All-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid; (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 13-cis-Acitretin; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
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CID: 5284513
TTD: D05QDC
DrugBank: DB00459
 Compound Name Brodalumab Approved [21]
Synonyms
AMG 827
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TTD: D05CEO
 Compound Name Coal tar Approved [12]
External Link
TTD: D03YET
 Compound Name Efalizumab Approved [22]
Synonyms
Raptiva; Raptiva (TN); Efalizumab (USAN/INN)
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TTD: D03SGR
 Compound Name Tapinarof Approved [23]
Synonyms
GSK-2894512
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CID: 6439522
TTD: D03DMB
DrugBank: DB06083
 Compound Name Calcipotriol Approved [24]
Synonyms
Calcipotriene; Divonex; Dovonex; BMS-181161; Daivonex (TN); Dovonex (TN); MC-903; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; (1S,5Z,7Z,17ALPHA,22E)-24-CYCLOPROPYL-9,10-SECOCHOLA-5,7,10,22-TETRAENE-1,3,24-TRIOL; 1-ALPHA,24S-(OH)2-22-ENE-26,27-DEHYDROVITAMIN D3
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External Link
CID: 5288783
TTD: D01QUS
DrugBank: DB02300
 Compound Name NPS-31807 Phase 4 [25]
Synonyms
PP-05; TNF alpha modulator (inflammation), Piramal Life Sciences; TNF alpha modulator (inflammation), NPIL Research & Development
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TTD: D0S0ST
 Compound Name LEO 80185 Phase 4 [26]
Synonyms
Taclonex
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External Link
CID: 9832804
TTD: D0FW2A
 Compound Name ARQ-151 Phase 3 [27]
External Link
TTD: DST04F
 Compound Name IB-MECA Phase 3 [28]
Synonyms
152918-18-8; piclidenoson; CF-101; 3-IB-Meca; N(6)-Ibamu; CF 101; Cf101; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine; UNII-30679UMI0N; N(6)-(3-Iodobenzyl)adenosine-5'-N-methyluronamide; 1-Deoxy-1-(6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-N-methyl-beta-D-ribofuranuronamide; CHEMBL119709; CHEBI:73286; 30679UMI0N; RPR-113090; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine; N(6)-(3-iodo-benzyl)adenosine-5'-N-methyluronamide
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CID: 123683
TTD: D0Y6ZK
DrugBank: DB05511
 Compound Name E-0116 Phase 3 [29]
External Link
TTD: D0V8GT
 Compound Name 5-methoxypsoralen Phase 3 [30]
Synonyms
5-MOP
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External Link
CID: 2355
TTD: D0QR5G
DrugBank: DB12216
 Compound Name RAVAX Phase 3 [31]
External Link
TTD: D0Q4GL
 Compound Name MK-3222 Phase 3 [32]
External Link
TTD: D0P1ME
 Compound Name Serlopitant Phase 2 [10]
Synonyms
VPD-737; UNII-277V92K32B; CHEMBL447955; 860642-69-9; 277V92K32B; 3-((3aR,4R,5S,7aS)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)hexahydro-1H-isoindol-2(3H)-yl)cyclopent-2-enone; Serlopitant [USAN:INN]; VPD 737; Serlopitant (USAN); SCHEMBL3183159; GTPL9280; mk-0594; FLNYCRJBCNNHRH-OIYLJQICSA-N; BDBM50277511; compound 17 (Jiang et al. 2009); DB12973; D09378; 3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-1H-isoindol-2-yl]cyclopent-2-en-1-one
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CID: 23653789
TTD: D0CB2B
DrugBank: DB12973
 Compound Name M-518101 Phase 3 [33]
External Link
TTD: D0A8KX
 Compound Name ASP-015K Phase 3 [34]
Synonyms
Peficitinib; ASP015K; UNII-HPH1166CKX; 944118-01-8; HPH1166CKX; 4-[[(1R,3S)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; Peficitinib [USAN:INN]; ASP 015K; JNJ-54781532; 9T6; Peficitinib (USAN/INN); SCHEMBL1154421; SCHEMBL9990248; SCHEMBL4447032; GTPL8315; SCHEMBL9990240; SCHEMBL1154418; CHEMBL3137308; SCHEMBL17645135; BCP18465; BDBM50124208; SB16834; DB11708; SC-17960; D10653; Peficitinib pound A
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CID: 57928403
TTD: D06EIC
DrugBank: DB11708
 Compound Name Fumaric acid Phase 3 [35]
Synonyms
Fum; Fumarsaeure; Acidum fumaricum; Allomaleic acid; Allomalenic acid; Ammonium fumarate; Boletic acid; Butenedioic acid; Kyselina fumarova; Kyselina fumarova [Czech]; Lichenic acid; Tumaric acid; F0067; OR17920; FC 33 (acid); Fumarate, 10; Fumaric acid (8CI); Fumaric acid (NF); Lichenic acid (VAN); S04-0167; Trans-Butenedioic acid; U-1149; E-2-Butenedioic acid; Trans-2-Butenedioic acid; USAF EK-P-583; Trans-1,2-Ethylenedicarboxylic acid; Trans-but-2-enedioic acid; (2E)-2-butenedioic acid; (2E)-but-2-enedioic acid; (E)-2-Butenedioic acid; 1,2-Ethylenedicarboxylic acid, (E); 2-(E)-Butenedioic acid; 2-Butenedioic acid; 2-Butenedioic acid (2E-(9CI)
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CID: 444972
TTD: D03GOO
DrugBank: DB01677
 Compound Name Bimosiamose Phase 2a [36]
Synonyms
TBC 1269; TBC-1269
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External Link
CID: 9811353
TTD: D02AUB
DrugBank: DB06197
 Compound Name JNJ-77242113 Phase 2 [37]
Synonyms
JNJ-2113
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TTD: DY2GF8
 Compound Name PF-07038124 Phase 2 [38]
Synonyms
(R)-4-(5-(4-Methoxy-3-propoxyphenyl)pyridin-3-yl)-1,2-oxaborolan-2-ol; 2415085-44-6; 3-[(4R)-2-hydroxyoxaborolan-4-yl]-5-(4-methoxy-3-propoxyphenyl)pyridine; BDBM589740; CS-0433935; Example 4 [US2020108083A1]; GLXC-25702; GTPL11950; HY-144683; M6ZU548FWD; PF 07038124 [WHO-DD]; PF07038124; PF-07038124; Pyridine, 3-((4R)-2-hydroxy-1,2-oxaborolan-4-yl)-5-(4-methoxy-3-propoxyphenyl)-; UNII-M6ZU548FWD; US11559538, Example 4
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CID: 148293990
TTD: D81WBS
 Compound Name IR502 Phase 2 [39]
Synonyms
Zorcell
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TTD: D0Z1CZ
 Compound Name VTP-43742 Phase 2 [28]
External Link
CID: 118282339
TTD: D0VB4X
 Compound Name Bertilimumab Phase 2 [28]
Synonyms
CAT-213; ICo-008
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External Link
TTD: D0V9LY
 Compound Name LEO 90100 Phase 2 [40]
External Link
TTD: D0V5VR
 Compound Name PF-06700841 Phase 2 [28]
Synonyms
BUWBRTXGQRBBHG-RUXDESIVSA-N; 2140301-96-6; PF-06700841 free base; EX-A2762; 1883299-62-4; ((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone
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External Link
CID: 118878093
TTD: D0V4DX
DrugBank: DB15003
 Compound Name LEO-32731 Phase 1 [41]
Synonyms
LP0058
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External Link
CID: 54765967
TTD: D0U9WS
 Compound Name Ascrolimus Phase 2 [42]
Synonyms
A-86281; ABT-281; ZK-248258
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External Link
CID: 9919023
TTD: D0SL8J
 Compound Name BMS-582949 Phase 2 [43]
Synonyms
623152-17-0; BMS 582949; UNII-CR743OME9E; BMS582949; CR743OME9E; PS540446; CHEMBL1230065; PS-540446; 4-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide; 3mvl; SCHEMBL254996; GTPL7838; DTXSID90211380; MolPort-044-560-326; EX-A1265; BCP14356; ZINC36475284; s8124; BDBM50327009; AKOS030573299; DB12696; Pyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide, 4-((5-((cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propyl-; BMS582949 free base; PS 540446
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External Link
CID: 10409068
TTD: D0Q0AP
DrugBank: DB12696
 Compound Name BT-061 Phase 2 [44]
External Link
TTD: D0NQ0V
 Compound Name VB-201 Phase 2 [45]
External Link
CID: 45138527
TTD: D0N2IE
DrugBank: DB15259
 Compound Name MK-0873 Phase 2 [46]
Synonyms
MK-0873 (dermatological, psoriasis); MK-0873 (dermatological, psoriasis), Merck & Co
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CID: 9919680
TTD: D0M7CB
DrugBank: DB13029
 Compound Name GSK2982772 Phase 1 [28]
Synonyms
LYPAFUINURXJSG-AWEZNQCLSA-N; 1622848-92-3; UNII-T5W3M0VO9B; T5W3M0VO9B; GSK-2982772; (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide; GTPL9554; SCHEMBL15956219; MolPort-044-830-634; s8484; AKOS030528033; compound 5 [PMID: 28151659]; ACN-041458; CS-6899; GSK 2982772; AS-35128; AC-29894; HY-101760; J3.650.802G; 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide; 3-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydr
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CID: 77108121
TTD: D0LQ3L
 Compound Name PH-10 Phase 2 [28]
Synonyms
Rose Bengal sodium salt; Bengal Rose B sodium salt; CI Acid red 94; NCGC00159508-02; disodium 2,3,4,5-tetrachloro-6-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoate; DSSTox_CID_2814; AC1L1NH9; AC1MC45U; DSSTox_RID_76740; DSSTox_GSID_22814; DTXSID4022814; CHEMBL2359093; CTK8G2989; Rose bengal, Dye content 95 %; UWBXIFCTIZXXLS-UHFFFAOYSA-L; Tox21_111727; MFCD00005043; GT2559; AKOS015902615; AKOS024319604; MCULE-2782240614; CAS-632-69-9; Tetrachlorotetraiodofluorescein disodium salt; ST50411638; F000
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External Link
CID: 32343
TTD: D0L1VF
 Compound Name ANB-019 Phase 2 [47]
External Link
TTD: D0G4JC
 Compound Name IP10 C8 Phase 2 [48]
Synonyms
IP10C8
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TTD: D0E3HY
 Compound Name BMS-986020 Phase 1 [28]
Synonyms
GQBRZBHEPUQRPL-LJQANCHMSA-N; 1257213-50-5; AP-3152 free acid; UNII-38CTP01B4L; 38CTP01B4L; SCHEMBL344742; GTPL9498; EX-A866; MolPort-044-616-249; ZINC113624125; AKOS030631907; CS-5844; AS-35060; HY-100619; FT-0700148; J-690107; Cyclopropanecarboxylic acid, 1-(4'-(3-methyl-4-((((1R)-1-phenylethoxy)carbonyl)amino)-5-isoxazolyl)(1,1'-biphenyl)-4-yl)-; 1-{4'-[3-Methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid; 1-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonyl
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CID: 49792850
TTD: D0D6ZW
DrugBank: DB14948
 Compound Name CMI-392 Phase 2 [49]
Synonyms
LDP-392; 3-[2-[2-(4-Chlorophenylsulfanyl)ethoxy]-3-methoxy-5-[trans-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl]benzyl]-1-hydroxy-1-methylurea
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External Link
CID: 6918268
TTD: D0D5ZV
 Compound Name Santalum album Phase 2 [28]
External Link
TTD: D0C8KP
 Compound Name CT 327 Phase 2 [50]
External Link
TTD: D0B7OY
 Compound Name RVT-505 Phase 2 [10]
External Link
TTD: D0AF5P
 Compound Name Rambazole Phase 2 [14]
Synonyms
Talarozole; 201410-53-9; R-115866; N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine; R115866; CHEMBL459505; C21H23N5S; Rambazole (TN); Talarozole (USAN/INN); Talarozole [USAN:INN]; R 115866; N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine; Talarozole pound> SCHEMBL721201; CHEBI:102167; MolPort-018-666-712; SNFYYXUGUBUECJ-UHFFFAOYSA-N; BCP28256; BCP21218; BDBM50253810; 0328AB; AKOS005067289; DB13083; CS-1343; NCGC00378894-01; HY-14531; AX8224298; D09385; W-5674; MEN13510
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External Link
CID: 9799888
TTD: D0AA6Z
DrugBank: DB13083
 Compound Name Siplizumab Discontinued in Phase 2 [51]
Synonyms
Siplizumab (USAN/INN)
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TTD: D0A7NB
 Compound Name IMO-3100 Phase 2 [52]
External Link
TTD: D08OXU
 Compound Name LLL-3348 Phase 2 [53]
Synonyms
Desoris; LL-3348; Herbal anti-inflammatory (psoriasis), Lupin
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External Link
TTD: D08HGR
 Compound Name Elisidepsin Phase 2 [54]
Synonyms
Irvalec; Elisidepsin trifluoroacetate; PM-02734; Erbb3 tyrosine kinase receptor inhibitor (cancer), PharmaMar; Kahalalide therapy (solid tumor), PharmaMar
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External Link
CID: 9855343
TTD: D08GIM
 Compound Name Santalum Phase 2 [10]
External Link
TTD: D06OVF
 Compound Name Apo805K1 Phase 2 [55]
External Link
CID: 76318569
TTD: D06HQM
 Compound Name BTT-1023 Phase 2 [56]
Synonyms
SI-3106; SI-636; Fully human VAP-1 mAbs (inflammation), BioTie/Seikagaku; Fully human VAP-1 monoclonal antibody (inflammation), BioTie/Seikagaku; VAP-1 antibody (rheumatoid arthritis/psoriasis), BioTie
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External Link
TTD: D06GUG
 Compound Name BFH-772 Phase 2 [57]
Synonyms
NVP-BFH-772
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CID: 24756034
TTD: D04OTY
 Compound Name LL-4218 Phase 2 [58]
Synonyms
Desoside-P
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External Link
TTD: D04MYS
 Compound Name BIM23A760 Discontinued in Phase 3 [59]
Synonyms
Lonapalene; RS-43179; 91431-42-4; UNII-WIF31Q54NJ; WIF31Q54NJ; CHEMBL36648; Lonapalenum; Lonapaleno; Lonapalenum [Latin]; Lonapaleno [Spanish]; Lonapalene (USAN); Lonapalene [USAN:INN]; RS 43179; 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate; (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate; AC1L1KN9; SCHEMBL120134; ZINC1630; DTXSID00238563; IFWMVQUGSGWCRP-UHFFFAOYSA-N; HY-U00156; BDBM50004677; CS-7197; ZB000377; D04770; 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene
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External Link
CID: 56237
TTD: D04FNQ
 Compound Name AN0128 Phase 2 [60]
Synonyms
Bis(3-chloro-4-methyl-phenyl)boranyl 3-hydroxypyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 3-hydroxy-, anhydride with bis(3-chloro-4-methylphenyl)borinic acid; 3-Hydroxypyridine-2-carbonyloxy-bis(3-chloro-4-methylphenyl)borane
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External Link
CID: 11704019
TTD: D03VPJ
 Compound Name DPS-102 Phase 2 [61]
Synonyms
Non-steroidal anti-inflammatory (topical dermatological, scalp psoriasis), DermiPsor
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External Link
TTD: D02TYV
 Compound Name LEO 22811 Phase 2 [62]
External Link
TTD: D01FZX
 Compound Name E6201 Phase 2 [63]
Synonyms
novel MEK inhibitors
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External Link
CID: 10172827
TTD: D01CNB
DrugBank: DB11687
 Compound Name Fezakinumab Phase 2 [64]
Synonyms
Fezakinumab (IV), fezakinumab (SC), ILV-094 (IV), ILV-094 (SC), PF-5212367 (IV) PF-5212367(SC)
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TTD: D01AIN
 Compound Name NN-8226 Phase 2 [65]
Synonyms
NNC-109-0012; IL-20 monoclonal antibody (inflammation), Novo Nordisk; Anti-IL20 (inflammation), ZymoGenetics/Novo Nordisk; Anti-IL20mAb (RA), ZymoGenetics/Novo Nordisk; Anti-interleukin-20 (rheumatoid arthritis), ZymoGenetics/Novo Nordisk
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External Link
TTD: D00LGA
 Compound Name Lunacalcipol Phase 2 [66]
Synonyms
CTA-018; MT-2832; Lunacalcipol (intravenous, secondary hyperparathyroidism); Lunacalcipol (intravenous, secondary hyperparathyroidism), Cytochroma; Vitamin D analogs (secondary hyperparathyroidism), Johns Hopkins/Cytochroma; CTA-018 (intravenous, secondary hyperparathyroidism), Cytochroma; CYP24 inhibitors (intravenous, secondary hyperparathyroidism), Johns Hopkins/Cytochroma
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CID: 10672195
TTD: D00DYK
 Compound Name Dalazatide Phase 1b/2a [67]
Synonyms
Dalazatide [INN]; UNII-6U0259J807; 1081110-69-1; o-PHOSPHONO-L-Tyrosyl-2-(2-(2-aminoethoxy)ethoxy)acetyl(potassium channel toxin kappa-stichotoxin-shela stoichactis helianthus (caribbean sea anemone)) peptidamide; 6U0259J807
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CID: 86278334
TTD: D0OK4O
 Compound Name Debio-0824 Phase 1b/2a [67]
Synonyms
Shk-192; ShK analogs (Subcutaneous formulation, autoimmune disease), Kineta; Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitors (injectable peptide, autoimmune disease); Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitor (Subcutaneous formulation, autoimmune disease), Airmid; Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitor (injectable peptide, autoimmune disease), Davis; Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitors (injectable peptide, autoimmune disease), Kineta One
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TTD: D01XEO
 Compound Name COVA322 Phase 1/2a [68]
External Link
TTD: D00BPH
 Compound Name AS-210 Phase 1/2 [69]
Synonyms
Psoraxine; AS-1001; AS-1002; AS-200; Psoriasis immunotherapy, Astralis/SkyePharma
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External Link
TTD: D0U8QC
 Compound Name ART621 Phase 1/2 [14]
External Link
TTD: D08KCK
 Compound Name JNJ-1459 Phase 1 [70]
External Link
TTD: DZ46KV
 Compound Name XCUR17 Phase 1 [10]
External Link
TTD: D0ZL5J
 Compound Name CM2489 Phase 1 [71]
External Link
TTD: D0W3JH
 Compound Name EDP1066 Phase 1 [10]
External Link
TTD: D0UD1J
 Compound Name BAY1834845 Phase 1 [10]
External Link
TTD: D0QQ7I
 Compound Name LEO-27989 Phase 1 [72]
External Link
TTD: D0QJ2K
 Compound Name SNA-125 Phase 1 [10]
External Link
TTD: D0Q0IM
 Compound Name ONS-3010 Phase 1 [28]
External Link
TTD: D0MI8Z
 Compound Name CC-90006 Phase 1 [10]
External Link
TTD: D0L5ZH
 Compound Name Pc4 Phase 1 [73]
Synonyms
Pc4 (topical formulation, cancer/psoriasis/dermatological disease) Fluence/CWRU/UHCMC
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TTD: D0L2YF
 Compound Name PRX003 Phase 1 [28]
External Link
TTD: D0L0DA
 Compound Name JNJ-3534 Phase 1 [10]
External Link
TTD: D0K9YJ
 Compound Name BBI-6000 Phase 1 [10]
External Link
TTD: D0FY4J
 Compound Name PF-06263276 Phase 1 [74]
External Link
CID: 135567296
TTD: D0DK5X
 Compound Name ALX-0761 Phase 1 [75]
External Link
TTD: D0B5UH
 Compound Name ILV-095 Phase 1 [76]
Synonyms
PF-05212368, WAY-264095
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External Link
TTD: D0A9GI
 Compound Name ARN-6039 Phase 1 [28]
Synonyms
BOS172767
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External Link
TTD: D0A0ZW
 Compound Name LY3316531 Phase 1 [10]
External Link
TTD: D08FIB
 Compound Name SAFINGOL Phase 1 [77]
Synonyms
Kynac; Kynacyte; SPC-100270; Safingol < Rec INN; L-threo-Dihydrosphingosine; SPC-100271 (HCl); (2S,3S)-2-Aminooctadecane-1,3-diol
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External Link
CID: 3058739
TTD: D07CAQ
DrugBank: DB11924
 Compound Name BCT-194 Phase 1 [78]
External Link
TTD: D06CSK
 Compound Name SB414 Phase 1 [10]
External Link
TTD: D02UYM
 Compound Name AST-005 Phase 1 [10]
External Link
TTD: D02PTI
 Compound Name Quinazoline derivative 12 Patented [79]
Synonyms
PMID26936077-Compound-23
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CID: 60163336
TTD: D0EC3H
 Compound Name Quinazoline derivative 10 Patented [79]
Synonyms
PMID26936077-Compound-21
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CID: 6737869
TTD: D0CM5P
 Compound Name Quinazoline derivative 11 Patented [79]
Synonyms
PMID26936077-Compound-22
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CID: 60163203
TTD: D08ZEM
 Compound Name PMID27998201-Compound-5 Patented [80]
External Link
CID: 46202117
TTD: D05OIU
 Compound Name VX-148 Patented [81]
Synonyms
SCHEMBL12343182; BDBM248095; VX-148 (3)
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CID: 56603796
TTD: D00RJA
 Compound Name IRX-4310 Discontinued in Phase 3 [82]
Synonyms
AGN-194310; AGN-4310; ALRT-4310; LGD-4310; NRX-4310; RARa antagonist (oral, chemotherapy-induced neutropenia), Io Therapeutics; Retinoic acid receptor alpha antagonist (oral, chemotherapy-induced neutropenia), Io Therapeutics
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External Link
TTD: D0T0LE
 Compound Name Etarotene Discontinued in Phase 3 [83]
Synonyms
Ro-15-1570; Ro-15-1570/000
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External Link
CID: 6435463
TTD: D0FQ6O
 Compound Name KC706 Discontinued in Phase 2 [84]
External Link
TTD: D0Y2HH
 Compound Name VTP-201227 Discontinued in Phase 2 [85]
External Link
TTD: D0X6XF
 Compound Name IC-747 Discontinued in Phase 2 [86]
Synonyms
LFA-1 antagonists, ICOS/Biogen
    Click to Show/Hide
External Link
TTD: D0W7GH
 Compound Name CRx-191 Discontinued in Phase 2 [87]
External Link
TTD: D0VA2I
 Compound Name LAS-37779 Discontinued in Phase 2 [88]
External Link
TTD: D0V2CN
 Compound Name TU-2100 Discontinued in Phase 2 [89]
External Link
CID: 4342838
TTD: D0P3TF
 Compound Name ASF-1075 Discontinued in Phase 2 [90]
External Link
TTD: D0KY4O
 Compound Name BMS-587101 Discontinued in Phase 2 [91]
Synonyms
BMS-688521
    Click to Show/Hide
External Link
CID: 11635371
TTD: D0GT8W
 Compound Name R-68151 Discontinued in Phase 2 [92]
Synonyms
1-Ethyl-3-{4-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-phenyl}-5,5-dimethyl-2-thioxo-imidazolidin-4-one; 5-Lipoxygenase-In-1; R 68151; CHEMBL85599; 138331-04-1; AC1L30HG; SCHEMBL13696698; DTXSID10160583; BDBM50006793; HY-U00308; CS-7300; (1-Ethyl-3(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)-5-dimethyl)-2-thioxo-4-imidazolidinone; 1-ethyl-3-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-5,5-dimethyl-2-sulfanylideneimidazolidin-4-one; M55551
    Click to Show/Hide
External Link
CID: 132150
TTD: D0G5GJ
 Compound Name T487 Discontinued in Phase 2 [93]
Synonyms
AC1MVK5U; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methyl-ethanamine; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methylethanamine
    Click to Show/Hide
External Link
CID: 12896
TTD: D0E6DI
 Compound Name SDZ-LAP-977 Discontinued in Phase 2 [94]
Synonyms
SDZ-281-977
    Click to Show/Hide
External Link
CID: 9818362
TTD: D0D5CJ
 Compound Name VML-262 Discontinued in Phase 2 [95]
Synonyms
Marigold compound (topical, psoriasis), University of Strathclyde; VAN-10-4 (topical, psoriasis), University of Strathclyde/Vanguard Medica
    Click to Show/Hide
External Link
TTD: D0CC1Y
 Compound Name SB-201993 Discontinued in Phase 2 [96]
Synonyms
UNII-4TWC061LPM; 4TWC061LPM; CHEMBL422598; SB 201993; AC1O5KJ7; SCHEMBL1893839; SCHEMBL1893835; sb201993; BDBM50037385; (E)-3-((((6-(2-Carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid; L009321; 3-[[6-[(E)-3-hydroxy-3-oxoprop-1-enyl]-5-[8-(4-methoxyphenyl)octoxy]pyridin-2-yl]methylsulfanylmethyl]benzoic acid; 3-{6-((E)-2-Carboxy-vinyl)-5-[8-(4-methoxy-phenyl)-octyloxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid; Benzoic acid, 3-((((6-(2-carboxyethenyl)-5-((8-(4-m
    Click to Show/Hide
External Link
CID: 6435820
TTD: D0B6JV
 Compound Name PVAC Discontinued in Phase 2 [97]
Synonyms
DDMV, Corixa/ Genesis/ Zenyaku Kogyo; Delipidated, deglycolipidated Mycobacterium vaccae, Corixa/ Genesis/ Zenyaku Kogyo
    Click to Show/Hide
External Link
TTD: D0B1NA
 Compound Name Tisocalcitate Discontinued in Phase 2 [98]
Synonyms
SH-597; ZK-156942; Calcitriol analog (topical formulation), Schering AG
    Click to Show/Hide
External Link
CID: 9913924
TTD: D07BDY
 Compound Name BAL-2299 Discontinued in Phase 2 [99]
Synonyms
Cyclohexanediol, Basilea
    Click to Show/Hide
External Link
TTD: D07AIE
 Compound Name Atocalcitol Discontinued in Phase 2 [100]
Synonyms
KH-1650
    Click to Show/Hide
External Link
CID: 6445225
TTD: D06SBK
 Compound Name FPL-64170 Discontinued in Phase 2 [101]
External Link
TTD: D04QVN
 Compound Name BIRT 2584 Discontinued in Phase 2 [91]
Synonyms
QSNSVPRLHYSSQG-AMXDTQDGSA-N; UNII-24P4O1J71F; 24P4O1J71F; SCHEMBL4017930; BIRT-2584; (S)-2-[(R)-7-(3,5-Dichloro-phenyl)-5-methyl-6-oxo-5-(4-trifluoromethoxy-benzyl)-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide; 688756-00-5
    Click to Show/Hide
External Link
CID: 10348691
TTD: D01WQO
 Compound Name SB 235699 Discontinued in Phase 1 [102]
Synonyms
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)pyridine; VK-19911; CHEMBL279416; UNII-NP7J08ZRYY; NP7J08ZRYY; 180869-32-3; SCHEMBL140202; HEP 689; sb235699; BDBM50099331; SB-235699; 4-(5-(4-Fluorophenyl)-3-(4-piperidyl)imidazol-4-yl)pyridine; Pyridine, 4-(4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl)-
    Click to Show/Hide
External Link
CID: 9797240
TTD: D0W0AM
 Compound Name PD-153035 Discontinued in Phase 1 [103]
Synonyms
183322-45-4; PD153035 hydrochloride; N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride; PD153035 HCl; PD 153035 HYDROCHLORIDE; PD-153035 hydrochloride; PD153035 (Hydrochloride); Tyrphostin AG 1517; AG 1517 hydrochloride; SU-5271 hydrochloride; UNII-AHJ252P69N; ZM 252868; SU 5271; AG 1517; 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE; AHJ252P69N; pd 153035; PD153035.HCl; CHEMBL1204168; 6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride; C16H15BrClN3O2; 4-Quinazolinamine, N-(3-bromo
    Click to Show/Hide
External Link
CID: 4705
TTD: D0Q7HO
 Compound Name ALS-00T2-0501 Discontinued in Phase 1 [104]
Synonyms
TNF Blocker (Intradel, psoriasis), Apollo Life Sciences; TNF Blocker (TransD, psoriasis), Apollo Life Sciences; TNF Blocker (transdermal cream, psoriasis), Apollo Life Sciences; TNF receptor antagonist (Intradel, psoriasis), Apollo Life Sciences; TNF receptor antagonist (TransD, psoriasis), Apollo Life Sciences; TNF receptor antagonist (transdermal cream, psoriasis), Apollo Life Sciences
    Click to Show/Hide
External Link
TTD: D05NUT
 Compound Name CCX-832 Discontinued in Phase 1 [105]
Synonyms
ChemR2 receptor antagonist (inflammation), ChemoCentryx/GlaxoSmithKline
    Click to Show/Hide
External Link
TTD: D04HZX
 Compound Name CLS008 Application submitted [10]
External Link
TTD: D0A6SD
 Compound Name DYV024 Preclinical [106]
External Link
TTD: DPW1K9
 Compound Name VCB102 Preclinical [107]
External Link
TTD: DG07UD
 Compound Name RAP-160 Preclinical [108]
External Link
TTD: D05VOP
 Compound Name ATL-1101 Preclinical [109]
External Link
TTD: D01QKD
 Compound Name Hu Dreg 55 Terminated [110]
Synonyms
SMART Anti-L-Selectin
    Click to Show/Hide
External Link
TTD: D0Z0HS
 Compound Name DB-200 Terminated [111]
Synonyms
DB-200 series (topical, psoriasis); CPT-1 inhibitor (topical, psoriasis), DARA; DB-200 series (topical, psoriasis), DARA BioSciences
    Click to Show/Hide
External Link
TTD: D0SG0N
 Compound Name MOR-102 Terminated [112]
Synonyms
MOR-101; MOR-101); ICAM-1 antibody (inflammation), MorphoSys
    Click to Show/Hide
External Link
TTD: D0M8JF
 Compound Name YP-008 Terminated [113]
Synonyms
RPL-228; Cyclopentenone prostaglandin mimetic (PGM) (topical, psoriasis), York Pharma; Natural-defence-prostanoid mimetic (topical, psoriasis), York Pharma
    Click to Show/Hide
External Link
TTD: D0L8TL
 Compound Name CRA-028129 Terminated [114]
External Link
TTD: D0K0IW
 Compound Name SB-209247 Terminated [115]
Synonyms
Ticolubant; LTB4 antagonist, SB
    Click to Show/Hide
External Link
CID: 6441619
TTD: D0G7SP
 Compound Name AD-177 Terminated [116]
External Link
TTD: D03JMN
 Compound Name R348 Terminated [14]
External Link
CID: 68254
TTD: D01XEQ
 Compound Name FM-301 Investigative [117]
External Link
TTD: D0U5SU
 Compound Name AZ-17 Investigative [117]
External Link
TTD: D0K0CK
 Compound Name Hairpin RNA Investigative [117]
Synonyms
Hairpin RNA (psoriasis); Hairpin RNA (psoriasis), SomaGenics; ShRNA (psoriasis), SomaGenics
    Click to Show/Hide
External Link
TTD: D0IY2B
 Compound Name KM-133 Investigative [117]
External Link
CID: 71605071
TTD: D0IC6D
DrugBank: DB12187
 Compound Name PU-2049 Investigative [117]
Synonyms
N-[2-(5-Methoxyindol-3-yl)ethyl]-10-undecenamide; 5-Methoxy-N-(10-undecenoyl)tryptamine
    Click to Show/Hide
External Link
TTD: D0I8QF
 Compound Name ASB-16165 Investigative [117]
Synonyms
PDE7 inhibitor (topical, psoriasis), Asubio
    Click to Show/Hide
External Link
CID: 25255436
TTD: D0C3ET
 Compound Name Amphiregulin targeting human mabs Investigative [117]
Synonyms
Amphiregulin targeting human mAbs (psoriasis)
    Click to Show/Hide
External Link
TTD: D0B1CJ
 Compound Name GSK-2263167 Investigative [117]
Synonyms
S1P1 agonists (psoriasis), GlaxoSmithKline; Sphingosine 1 phosphate-1 agonists (psoriasis); Sphingosine 1 phosphate-1 agonists (psoriasis), GlaxoSmithKline
    Click to Show/Hide
External Link
TTD: D08UDB
 Compound Name DPS-151 Investigative [117]
External Link
TTD: D08UAT
 Compound Name LPD-1050 Investigative [117]
External Link
TTD: D08EQQ
 Compound Name CXCL8 Investigative [117]
Synonyms
Interleukin-8; CHEMBL411250; IL-8
    Click to Show/Hide
External Link
CID: 74974005
TTD: D07PHS
 Compound Name DM-512 Investigative [117]
External Link
TTD: D06TAR
 Compound Name KIN-4050 Investigative [117]
Synonyms
ERK inhibitor (topical, psoriasis), Kinentia; MAP kinase inhibitor (topical, psoriasis), Kinentia
    Click to Show/Hide
External Link
TTD: D06MTH
 Compound Name Ankinara Investigative [118]
External Link
TTD: D05TZJ
 Compound Name BL-7020 Investigative [117]
Synonyms
Recombinant IGFBP (intradermal, psoriasis), BioLineRx
    Click to Show/Hide
External Link
TTD: D04FHY
 Compound Name X-083-NAB Investigative [117]
Synonyms
NATHMAB (psoriasis/Crohns disease/type 1 diabetes), XBiotech; Unspecified cytokine receptor antagonist (human monoclonal antibody, psoriasis/Crohns disease/type 1 diabetes), XBiotech
    Click to Show/Hide
External Link
TTD: D04ASA
 Compound Name LEO-90110 Investigative [117]
External Link
TTD: D01ATS
References
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