m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0114)
| Name |
Chondropathies
|
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|---|---|---|---|---|---|
| ICD |
ICD-11: FB82
|
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Full List of Target Gene(s) of This m6A-centered Disease Response
Microprocessor complex subunit DGCR8 (DGCR8)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Interleukin 1-beta (IL-1-beta) is an important inducer of cartilage degeneration that can induce an inflammatory cascade reaction in chondrocytes and inhibit the normal biological function of cells. METTL3 could regulate miR-126-5p maturation, we first confirmed that METTL3 can bind the key protein underlying pri-miRNA processing, Microprocessor complex subunit DGCR8 (DGCR8). Additionally, when METTL3 expression was inhibited, the miR-126-5p maturation process was blocked. | |||
| Responsed Disease | Chondropathies [ICD-11: FB82] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | RNA mature | |||
| In-vitro Model | Cartilage cells (From the cartilage tissue samples from patients) | |||
hsa-miR-126-5p
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Interleukin 1-beta (IL-1-beta) is an important inducer of cartilage degeneration that can induce an inflammatory cascade reaction in chondrocytes and inhibit the normal biological function of cells. METTL3 could regulate hsa-miR-126-5p maturation, we first confirmed that METTL3 can bind the key protein underlying pri-miRNA processing, DGCR8. Additionally, when METTL3 expression was inhibited, the miR-126-5p maturation process was blocked. | |||
| Responsed Disease | Chondropathies [ICD-11: FB82] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | RNA mature | |||
| In-vitro Model | Cartilage cells (From the cartilage tissue samples from patients) | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 2 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05001 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | . | |
| Epigenetic Regulator | hsa-miR-27a | |
| Regulated Target | YTH domain-containing family protein 2 (YTHDF2) | |
| Crosstalk relationship | ncRNA → m6A | |
| Crosstalk ID: M6ACROT05449 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | hsa-miR-126-5p | |
| Epigenetic Regulator | hsa-miR-126-5p | |
| Regulated Target | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3K-p85/PIK3R2) | |
| Crosstalk relationship | m6A → ncRNA | |