m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05001
|
[1] | |||
Non-coding RNA
miR27a
YTHDF2
lncRNA miRNA circRNA
Direct
Inhibition
m6A modification
m6A Target
m6A Target
YTHDF2
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | READER | |||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | hsa-miR-27a | microRNA | View Details | ||
| Regulated Target | YTH domain-containing family protein 2 (YTHDF2) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Inhibition | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator | ||||
| Crosstalk Summary | hsa-miR-27a exerts a protective effect on SNFH by negatively regulating YTHDF2 expression, leading to a reduction in m6A methylation in BMSCs. | ||||
| Responsed Disease | Steroid-induced necrosis of the femoral head | ICD-11: FB82.1 | |||
| Cell Process | Cell differentiation | ||||
In-vitro Model |
BMSCs (BMSCs were obtained from the femurs and tibias of 2-3-week-old Sprague-Dawley male rats (Animal Center of Sun Yat-sen University)) | ||||