m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0024)
| Name |
Chronic pain
|
||||
|---|---|---|---|---|---|
| ICD |
ICD-11: MG30
|
||||
Full List of Target Gene(s) of This m6A-centered Disease Response
Methylcytosine dioxygenase TET1 (TET1)
| In total 2 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Downregulated spinal cord METTL3 coordinating with YTHDF2 contributes to the modulation of inflammatory pain through stabilizing upregulation of Methylcytosine dioxygenase TET1 (TET1) in spinal neurons. | |||
| Responsed Disease | Chronic pain [ICD-11: MG30] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Downregulated spinal cord METTL3 coordinating with YTHDF2 contributes to the modulation of inflammatory pain through stabilizing upregulation of Methylcytosine dioxygenase TET1 (TET1) in spinal neurons. | |||
| Responsed Disease | Chronic pain [ICD-11: MG30] | |||
| Target Regulator | YTH domain-containing family protein 2 (YTHDF2) | READER | ||
| Target Regulation | Down regulation | |||
mmu-miR-365-3p
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
| Response Summary | METTL3 positively modulated the mmu-miR-365-3p processing in a microprocessor protein DiGeorge critical region 8-dependent manner.METTL3-mediated m6A modification in nociceptive sensitization and provide a novel perspective on m6A modification in the development of Inflammatory pain. | |||
| Responsed Disease | Chronic pain [ICD-11: MG30] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | MicroRNAs in cancer | hsa05206 | ||
| Cell Process | RNA stability | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 3 item(s) under this disease | ||
| Crosstalk ID: M6ACROT02094 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Methylcytosine dioxygenase TET1 (TET1) | |
| Epigenetic Regulator | Methylcytosine dioxygenase TET1 (TET1) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → DNA modification | |
| Crosstalk ID: M6ACROT02095 | ||
| m6A Regulator | YTH domain-containing family protein 2 (YTHDF2) | |
| m6A Target | Methylcytosine dioxygenase TET1 (TET1) | |
| Epigenetic Regulator | Methylcytosine dioxygenase TET1 (TET1) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → DNA modification | |
| Crosstalk ID: M6ACROT05411 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | mmu-miR-365-3p | |
| Epigenetic Regulator | mmu-miR-365-3p | |
| Crosstalk relationship | m6A → ncRNA | |
References