m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0005)
| Name |
Hypopharyngeal cancer
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|---|---|---|---|---|---|
| ICD |
ICD-11: 2B6D
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Full List of Target Gene(s) of This m6A-centered Disease Response
Transferrin receptor protein 1 (TFRC)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | YTHDF1 enhanced Transferrin receptor protein 1 (TFRC) expression in HPSCC through an m6A-dependent mechanism. | |||
| Responsed Disease | Hypopharyngeal squamous cell carcinoma [ICD-11: 2B6D.0] | |||
| Target Regulator | YTH domain-containing family protein 1 (YTHDF1) | READER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Ferroptosis | hsa04216 | ||
| Cell Process | Ferroptosis | |||
| In-vitro Model | YCU-MS861 | Maxillary sinus squamous cell carcinoma | Homo sapiens | CVCL_8021 |
| YCU-MS861 | Maxillary sinus squamous cell carcinoma | Homo sapiens | CVCL_8021 | |
| FaDu | Hypopharyngeal squamous cell carcinoma | Homo sapiens | CVCL_1218 | |
| Detroit 562 | Pharyngeal squamous cell carcinoma | Homo sapiens | CVCL_1171 | |
hsa_circ_0081609 (circ_CUX1)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
| Response Summary | METTL3-mediated m6A modification plays a key role in stabilizing the expression of hsa_circ_0081609 (circCUX1), thereby inhibiting the expression of caspase 1 and conferring the radiotherapy resistance of hypopharyngeal squamous cell carcinoma. | |||
| Responsed Disease | Hypopharyngeal squamous cell carcinoma [ICD-11: 2B6D.0] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | CLA-27 cell line (The head and neck tumor cell lines) | |||
| HOK | Normal | Hexagrammos otakii | CVCL_YE19 | |
| SAS | Tongue squamous cell carcinoma | Homo sapiens | CVCL_1675 | |
| SCC-15 | Tongue squamous cell carcinoma | Homo sapiens | CVCL_1681 | |
| SCC-4 | Tongue squamous cell carcinoma | Homo sapiens | CVCL_1684 | |
| SCC-9 | Tongue squamous cell carcinoma | Homo sapiens | CVCL_1685 | |
| Tca8113 | Endocervical adenocarcinoma | Homo sapiens | CVCL_6851 | |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 1 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05484 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | hsa_circ_0081609 (circ_CUX1) | |
| Epigenetic Regulator | hsa_circ_0081609 (Circ_CUX1) | |
| Regulated Target | Caspase-1 (CASP1) | |
| Crosstalk relationship | m6A → ncRNA | |
References