m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00070)
Target Name hsa_circ_0081609 (circ_CUX1)
Gene Name Circ_CUX1
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_CUX1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3-mediated m6A modification plays a key role in stabilizing the expression of hsa_circ_0081609 (circCUX1), thereby inhibiting the expression of caspase 1 and conferring the radiotherapy resistance of hypopharyngeal squamous cell carcinoma.
Target Regulation Up regulation
Responsed Disease Hypopharyngeal squamous cell carcinoma ICD-11: 2B6D.0
 Disease Info 
In-vitro Model CLA-27 cell line (The head and neck tumor cell lines)
HOK Normal Hexagrammos otakii CVCL_YE19
SAS Tongue squamous cell carcinoma Homo sapiens CVCL_1675
SCC-15 Tongue squamous cell carcinoma Homo sapiens CVCL_1681
SCC-4 Tongue squamous cell carcinoma Homo sapiens CVCL_1684
SCC-9 Tongue squamous cell carcinoma Homo sapiens CVCL_1685
Tca8113 Endocervical adenocarcinoma Homo sapiens CVCL_6851
Hypopharyngeal cancer [ICD-11: 2B6D]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3-mediated m6A modification plays a key role in stabilizing the expression of hsa_circ_0081609 (circCUX1), thereby inhibiting the expression of caspase 1 and conferring the radiotherapy resistance of hypopharyngeal squamous cell carcinoma.
Responsed Disease Hypopharyngeal squamous cell carcinoma [ICD-11: 2B6D.0]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
In-vitro Model CLA-27 cell line (The head and neck tumor cell lines)
HOK Normal Hexagrammos otakii CVCL_YE19
SAS Tongue squamous cell carcinoma Homo sapiens CVCL_1675
SCC-15 Tongue squamous cell carcinoma Homo sapiens CVCL_1681
SCC-4 Tongue squamous cell carcinoma Homo sapiens CVCL_1684
SCC-9 Tongue squamous cell carcinoma Homo sapiens CVCL_1685
Tca8113 Endocervical adenocarcinoma Homo sapiens CVCL_6851
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05484
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0081609 (Circ_CUX1)
Regulated Target Caspase-1 (CASP1)
Crosstalk relationship m6A → ncRNA
Disease Hypopharyngeal cancer
 Disease Info 
References
Ref 1 N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway. Cell Death Dis. 2021 Mar 19;12(4):298. doi: 10.1038/s41419-021-03558-2.