m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00198)
Target Name Bax inhibitor 1 (TMBIM6)
Synonyms
BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6; BI1; TEGT
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Gene Name TMBIM6
Chromosomal Location 12q13.12
Family BI1 family
Function
Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
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Gene ID 7009
Uniprot ID
BI1_HUMAN
HGNC ID
HGNC:11723
Ensembl Gene ID
ENSG00000139644
KEGG ID
hsa:7009
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
TMBIM6 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by IGF2BP3
Cell Line ES-2 cell line Homo sapiens
Treatment: siIGF2BP3 ES-2 cells
Control: siControl ES-2 cells
 GSE109604
Regulation
logFC: -8.65E-01
p-value: 2.88E-02
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary RBM15-mediated m6A modification of Bax inhibitor 1 (TMBIM6) mRNA enhanced TMBIM6 stability through IGF2BP3-dependent. Laryngeal squamous cell cancer cells were transfected with shRBM15 lentivirus for 48h, and the qRT-PCR data indicated that the mRNA levels of CPNE5, TMBIM6, and ATAD3A decreased after RBM15 knockdown.
Target Regulation Up regulation
Responsed Disease Laryngeal cancer ICD-11: 2C23
 Disease Info 
Cell Process RNA stability
Cell apoptosis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
NHBEC (Normal human bronchial epithelial cell)
Tu 177 Laryngeal squamous cell carcinoma Homo sapiens CVCL_4913
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model For tumor growth studies, whether in vivo RBM15 knockdown/overexpression experiments or in vivo rescue experiments, each group included six mice. Each mouse was injected with 100 uL of lentivirus-transfected tumor cells.
RNA-binding motif protein 15 (RBM15) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by RBM15
Cell Line Human BJ Fibroblast Homo sapiens
Treatment: siRBM15 BJ fibroblast
Control: siControl BJ fibroblast
 GSE154148
Regulation
logFC: -3.57E+00
p-value: 2.49E-07
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary RBM15-mediated m6A modification of Bax inhibitor 1 (TMBIM6) mRNA enhanced TMBIM6 stability through IGF2BP3-dependent. Laryngeal squamous cell cancer cells were transfected with shRBM15 lentivirus for 48h, and the qRT-PCR data indicated that the mRNA levels of CPNE5, TMBIM6, and ATAD3A decreased after RBM15 knockdown.
Target Regulation Up regulation
Responsed Disease Laryngeal cancer ICD-11: 2C23
 Disease Info 
Cell Process RNA stability
Cell apoptosis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
NHBEC (Normal human bronchial epithelial cell)
Tu 177 Laryngeal squamous cell carcinoma Homo sapiens CVCL_4913
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model For tumor growth studies, whether in vivo RBM15 knockdown/overexpression experiments or in vivo rescue experiments, each group included six mice. Each mouse was injected with 100 uL of lentivirus-transfected tumor cells.
Laryngeal cancer [ICD-11: 2C23]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary RBM15-mediated m6A modification of Bax inhibitor 1 (TMBIM6) mRNA enhanced TMBIM6 stability through IGF2BP3-dependent. Laryngeal squamous cell cancer cells were transfected with shRBM15 lentivirus for 48h, and the qRT-PCR data indicated that the mRNA levels of CPNE5, TMBIM6, and ATAD3A decreased after RBM15 knockdown.
Responsed Disease Laryngeal cancer [ICD-11: 2C23]
Target Regulator Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process RNA stability
Cell apoptosis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
NHBEC (Normal human bronchial epithelial cell)
Tu 177 Laryngeal squamous cell carcinoma Homo sapiens CVCL_4913
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model For tumor growth studies, whether in vivo RBM15 knockdown/overexpression experiments or in vivo rescue experiments, each group included six mice. Each mouse was injected with 100 uL of lentivirus-transfected tumor cells.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary RBM15-mediated m6A modification of Bax inhibitor 1 (TMBIM6) mRNA enhanced TMBIM6 stability through IGF2BP3-dependent. Laryngeal squamous cell cancer cells were transfected with shRBM15 lentivirus for 48h, and the qRT-PCR data indicated that the mRNA levels of CPNE5, TMBIM6, and ATAD3A decreased after RBM15 knockdown.
Responsed Disease Laryngeal cancer [ICD-11: 2C23]
Target Regulator RNA-binding motif protein 15 (RBM15) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process RNA stability
Cell apoptosis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
NHBEC (Normal human bronchial epithelial cell)
Tu 177 Laryngeal squamous cell carcinoma Homo sapiens CVCL_4913
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model For tumor growth studies, whether in vivo RBM15 knockdown/overexpression experiments or in vivo rescue experiments, each group included six mice. Each mouse was injected with 100 uL of lentivirus-transfected tumor cells.
References
Ref 1 RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. J Exp Clin Cancer Res. 2021 Feb 26;40(1):80. doi: 10.1186/s13046-021-01871-4.