m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00154)
Target Name KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1)
Synonyms
KCNQ1OT1; KCNQ1 opposite strand/antisense transcript 1 (non-protein coding); KvDMR1; KCNQ1-AS2; KvLQT1-AS; LIT1; NCRNA00012; non-protein coding RNA 12; KCNQ1 antisense RNA 2 (non-protein coding); KCNQ1 overlapping transcript 1 (non-protein coding)
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Gene Name KCNQ1OT1
Chromosomal Location 11p15.5
Family Long non-coding RNAs with non-systematic symbols
Gene ID 10984
HGNC ID
HGNC:6295
Ensembl Gene ID
ENSG00000269821
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
KCNQ1OT1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5
Cell Line NOMO-1 cell line Homo sapiens
Treatment: shALKBH5 NOMO-1 cells
Control: shNS NOMO-1 cells
 GSE144968
Regulation
logFC: 1.52E+00
p-value: 9.12E-06
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 mediates KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) expression via an m6A-YTHDF2-dependent manner and KCNQ1OT1 could directly bind to HOXA9 to further regulate the proliferation, invasion and metastasis of laryngeal squamous cell carcinoma cells.
Target Regulation Up regulation
Responsed Disease Laryngeal cancer ICD-11: 2C23
 Disease Info 
Cell Process Cell proliferation and metastasis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
HOK Normal Hexagrammos otakii CVCL_YE19
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model 1 × 106 (100 ul) cells of infected and uninfected by lentiviral were, respectively, injected subcutaneously into nude mice which divided randomly into scramble group and shKCNQ1OT1-1 group.
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF2
Cell Line Human umbilical cord blood CD34+ cells Homo sapiens
Treatment: YTHDF2 knockdown UCB CD34+ cells
Control: Wild type UCB CD34+ cells
 GSE107956
Regulation
logFC: 5.92E-01
p-value: 2.94E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary ALKBH5 mediates KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) expression via an m6A-YTHDF2-dependent manner and KCNQ1OT1 could directly bind to HOXA9 to further regulate the proliferation, invasion and metastasis of laryngeal squamous cell carcinoma cells.
Target Regulation Up regulation
Responsed Disease Laryngeal cancer ICD-11: 2C23
 Disease Info 
Cell Process Cell proliferation and metastasis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
HOK Normal Hexagrammos otakii CVCL_YE19
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model 1 × 106 (100 ul) cells of infected and uninfected by lentiviral were, respectively, injected subcutaneously into nude mice which divided randomly into scramble group and shKCNQ1OT1-1 group.
Laryngeal cancer [ICD-11: 2C23]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 mediates KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) expression via an m6A-YTHDF2-dependent manner and KCNQ1OT1 could directly bind to HOXA9 to further regulate the proliferation, invasion and metastasis of laryngeal squamous cell carcinoma cells.
Responsed Disease Laryngeal cancer [ICD-11: 2C23]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation and metastasis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
HOK Normal Hexagrammos otakii CVCL_YE19
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model 1 × 106 (100 ul) cells of infected and uninfected by lentiviral were, respectively, injected subcutaneously into nude mice which divided randomly into scramble group and shKCNQ1OT1-1 group.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary ALKBH5 mediates KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) expression via an m6A-YTHDF2-dependent manner and KCNQ1OT1 could directly bind to HOXA9 to further regulate the proliferation, invasion and metastasis of laryngeal squamous cell carcinoma cells.
Responsed Disease Laryngeal cancer [ICD-11: 2C23]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Up regulation
Cell Process Cell proliferation and metastasis
In-vitro Model AMC-HN-8 Laryngeal squamous cell carcinoma Homo sapiens CVCL_5966
HOK Normal Hexagrammos otakii CVCL_YE19
Tu 212 Head and neck squamous cell carcinoma Homo sapiens CVCL_4915
In-vivo Model 1 × 106 (100 ul) cells of infected and uninfected by lentiviral were, respectively, injected subcutaneously into nude mice which divided randomly into scramble group and shKCNQ1OT1-1 group.
References
Ref 1 ALKBH5-mediated m6A modification of lncRNA KCNQ1OT1 triggers the development of LSCC via upregulation of HOXA9. J Cell Mol Med. 2022 Jan;26(2):385-398. doi: 10.1111/jcmm.17091. Epub 2021 Dec 1.