m6A Regulator and Potential Drug Response

General Information of the m6A Regulator (ID: REG00020)
Regulator Name RNA-binding motif protein 15 (RBM15)
Synonyms
One-twenty two protein 1; RNA-binding protein 15; OTT; OTT1
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Gene Name RBM15
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Mammalian target of rapamycin complex 1 (mTORC1)
RBT-101 [Phase 3]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [1], [2]
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for AZD-2014. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of AZD-2014 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [1], [3]
ME-344 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for ME-344. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of ME-344 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [1], [4]
NV-5138 [Phase 1]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [1], [5]
Palomid-529 [Phase 1]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for Palomid-529. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of Palomid-529 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [1], [4]
VS-5584 [Phase 1]
In total 1 mechanisms lead to this potential drug response
 Drug Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for VS-5584. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of VS-5584 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [1], [6]
References
Ref 1 mTORC1-chaperonin CCT signaling regulates m(6)A RNA methylation to suppress autophagy. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2021945118. doi: 10.1073/pnas.2021945118.
Ref 2 PPARGamma ligands and their therapeutic applications: a patent review (2008 - 2014). Expert Opin Ther Pat. 2015 Feb;25(2):175-91. doi: 10.1517/13543776.2014.985206. Epub 2014 Nov 21.
Ref 3 Constrained peptides' time to shine?. Nat Rev Drug Discov. 2018 Jul 30;17(8):531-533. doi: 10.1038/nrd.2018.125.
Ref 4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 5 Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2. Int J Cancer. 2013 Sep 1;133(5):1222-33. doi: 10.1002/ijc.28126. Epub 2013 Apr 1.
Ref 6 Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. doi: 10.1172/JCI126859.