m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG04282)
Name
RBT-101
Synonyms
RBT-102; RBT-103; RBT-104; Seasonal/pandemic influenza vaccines (VLPs); Seasonal/pandemic influenza vaccines (VLPs), Redbiotec; Seasonal/pandemic influenza vaccines (virus-like-particles), Redbiotec
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Status
Phase 3
TTD Drug ID
D0NO0K
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Mammalian target of rapamycin complex 1 (mTORC1)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [2], [3]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [2], [3]
RNA-binding motif protein 15 (RBM15)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [2], [3]
RNA-binding motif protein 15B (RBM15B)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The RNA-binding motif protein 15B (RBM15B) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [2], [3]
Wilms tumor 1-associating protein (WTAP)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for RBT-101. The Wilms tumor 1-associating protein (WTAP) has potential in affecting the response of RBT-101 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). [2], [3]
References
Ref 1 Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation. Biosci Rep. 2021 Jan 29;41(1):BSR20200842. doi: 10.1042/BSR20200842.
Ref 2 PPARGamma ligands and their therapeutic applications: a patent review (2008 - 2014). Expert Opin Ther Pat. 2015 Feb;25(2):175-91. doi: 10.1517/13543776.2014.985206. Epub 2014 Nov 21.
Ref 3 mTORC1-chaperonin CCT signaling regulates m(6)A RNA methylation to suppress autophagy. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2021945118. doi: 10.1073/pnas.2021945118.