m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG00586)
| Name |
NV-5138
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| Synonyms |
UNII-06CA9QMG6Z; 4-(difluoromethyl)-L-leucine; 2095886-80-7; SCHEMBL18762589; ZINC585143195; HY-114384; N[C@H](C(=O)O)CC(C(F)F)(C)C; CS-0084893; ((S)-2-Amino-5,5-difluoro-4,4-dimethylpentanoic acid; Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-; K94
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| Status |
Phase 1
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| Structure |
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| Formula |
C7H13F2NO2
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| InChI |
1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1
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| InChIKey |
HRFIMCJTDKEPPV-BYPYZUCNSA-N
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| PubChem CID | |||||
| TTD Drug ID | |||||
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Mammalian target of rapamycin complex 1 (mTORC1)
Fat mass and obesity-associated protein (FTO)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). | [1], [2] | ||
Methyltransferase-like 14 (METTL14)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). | [2], [3] | ||
Methyltransferase-like 3 (METTL3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). | [2], [3] | ||
RNA-binding motif protein 15 (RBM15)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The RNA-binding motif protein 15 (RBM15) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). | [2], [3] | ||
RNA-binding motif protein 15B (RBM15B)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The RNA-binding motif protein 15B (RBM15B) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). | [2], [3] | ||
Wilms tumor 1-associating protein (WTAP)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Mammalian target of rapamycin complex 1 (mTORC1) is a therapeutic target for NV-5138. The Wilms tumor 1-associating protein (WTAP) has potential in affecting the response of NV-5138 through regulating the expression of Mammalian target of rapamycin complex 1 (mTORC1). | [2], [3] | ||
References