m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0163)
Name
Disorders of the retina
ICD
ICD-11: 9B70-9C0Z
Full List of Target Gene(s) of This m6A-centered Disease Response
Microtubule-associated protein 2 (MAP2)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary The expression of METTL14 is significantly reduced in patients with retinitis pigmentosa (RP). METTL14 regulates the expression of Microtubule-associated protein 2 (MAP2) via the modification of m6A, resulting in the dysregulation of NEUROD1 and pathologic changes in RPE cells.
Responsed Disease Disorders of the retina [ICD-11: 9B70-9C0Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model ARPE-19 Normal Homo sapiens CVCL_0145
Neurogenic differentiation factor 1 (NEUROD1)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary The expression of METTL14 is significantly reduced in patients with retinitis pigmentosa (RP). METTL14 regulates the expression of MAP2 via the modification of m6A, resulting in the dysregulation of Neurogenic differentiation factor 1 (NEUROD1) and pathologic changes in RPE cells.
Responsed Disease Disorders of the retina [ICD-11: 9B70-9C0Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model ARPE-19 Normal Homo sapiens CVCL_0145
References
Ref 1 Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2. Bioengineered. 2022 Mar;13(3):4773-4785. doi: 10.1080/21655979.2022.2032968.