m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00611)
Target Name Microtubule-associated protein 2 (MAP2)
Synonyms
MAP-2
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Gene Name MAP2
Chromosomal Location 2q34
Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
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Gene ID 4133
Uniprot ID
MTAP2_HUMAN
HGNC ID
HGNC:6839
Ensembl Gene ID
ENSG00000078018
KEGG ID
hsa:4133
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MAP2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL14-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: 3.37E+00
p-value: 1.21E-131
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The expression of METTL14 is significantly reduced in patients with retinitis pigmentosa (RP). METTL14 regulates the expression of Microtubule-associated protein 2 (MAP2) via the modification of m6A, resulting in the dysregulation of NEUROD1 and pathologic changes in RPE cells.
Target Regulation Down regulation
Responsed Disease Disorders of the retina ICD-11: 9B70-9C0Z
 Disease Info 
In-vitro Model ARPE-19 Normal Homo sapiens CVCL_0145
Disorders of the retina [ICD-11: 9B70-9C0Z]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The expression of METTL14 is significantly reduced in patients with retinitis pigmentosa (RP). METTL14 regulates the expression of Microtubule-associated protein 2 (MAP2) via the modification of m6A, resulting in the dysregulation of NEUROD1 and pathologic changes in RPE cells.
Responsed Disease Disorders of the retina [ICD-11: 9B70-9C0Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model ARPE-19 Normal Homo sapiens CVCL_0145
References
Ref 1 Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2. Bioengineered. 2022 Mar;13(3):4773-4785. doi: 10.1080/21655979.2022.2032968.