General Information of the m6A Target Gene (ID: M6ATAR00612)
Target Name Neurogenic differentiation factor 1 (NEUROD1)
Synonyms
NeuroD; NeuroD1; Class A basic helix-loop-helix protein 3; bHLHa3
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Gene Name NEUROD1
Chromosomal Location 2q31.3
Function
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
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Gene ID 4760
Uniprot ID
NDF1_HUMAN
HGNC ID
HGNC:7762
Ensembl Gene ID
ENSG00000162992
KEGG ID
hsa:4760
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
NEUROD1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 14 (METTL14) [WRITER]
Representative RNA-seq result indicating the expression of this target gene regulated by METTL14
Cell Line Embryonic stem cells Mus musculus
Treatment: METTL14 knockout mESCs
Control: Wild type mESCs
GSE156481
Regulation
logFC: -2.82E+00
p-value: 1.42E-13
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The expression of METTL14 is significantly reduced in patients with retinitis pigmentosa (RP). METTL14 regulates the expression of MAP2 via the modification of m6A, resulting in the dysregulation of Neurogenic differentiation factor 1 (NEUROD1) and pathologic changes in RPE cells.
Target Regulation Down regulation
Responsed Disease Disorders of the retina ICD-11: 9B70-9C0Z
In-vitro Model ARPE-19 Normal Homo sapiens CVCL_0145
Disorders of the retina [ICD-11: 9B70-9C0Z]
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The expression of METTL14 is significantly reduced in patients with retinitis pigmentosa (RP). METTL14 regulates the expression of MAP2 via the modification of m6A, resulting in the dysregulation of Neurogenic differentiation factor 1 (NEUROD1) and pathologic changes in RPE cells.
Responsed Disease Disorders of the retina [ICD-11: 9B70-9C0Z]
Target Regulator Methyltransferase-like 14 (METTL14) WRITER
Target Regulation Down regulation
In-vitro Model ARPE-19 Normal Homo sapiens CVCL_0145
References
Ref 1 Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2. Bioengineered. 2022 Mar;13(3):4773-4785. doi: 10.1080/21655979.2022.2032968.