Name	Inflammatory response
ICD	ICD-11: MG46

In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Smad7 and E3 ubiquitin-protein ligase SMURF1 (SMURF1) mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Smad7 and E3 ubiquitin-protein ligase SMURF1 (SMURF1) mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[2]
Response Summary	YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of Forkhead box protein O3 (FOXO3) mRNA under homeostatic conditions, adding insight into the networks of RNA-binding protein-RNA interactions in homeostatically maintaining host antiviral immune function and preventing inflammatory response.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	YTH domain-containing family protein 3 (YTHDF3)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	FoxO signaling pathway			hsa04068
In-vivo Model	YTHDF3-/- mice were generated using the CRISPR-Cas9 system.

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[3]
Response Summary	YTHDF2 knockdown increases mRNA expression levels of MAP2K4 and HPK/GCK-like kinase HGK (MAP4K4) via stabilizing the mRNA transcripts, which activate MAPK and NF-Kappa-B signaling pathways, which promote the expression of proinflammatory cytokines and aggravate the inflammatory response in LPS-stimulated RAW 264.7 cells.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	RAW 264.7	Mouse leukemia	Mus musculus	CVCL_0493

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[4]
Response Summary	lnc-Dpf3 directly bound to Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) and suppressed HIF-1-alpha-dependent transcription of the glycolytic gene Ldha, thus inhibiting DC glycolytic metabolism and migratory capacity. CCR7-inducible lnc-Dpf3 in coupling epigenetic and metabolic pathways to feedback-control DC migration and inflammatory responses.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Pathway Response	HIF-1 signaling pathway			hsa04066
Cell Process	Glycolysis
	Immune responses
	Inflammatory injuries
In-vitro Model	CD11c+ DC cell (CD11c positive dendritic cells)
	CD19+ B cell line (CD19+ human B lymphoma cells)
	CD4+ T cell line (A T-helper cell)
	DX5+ NK cell line (Unique subsets of NK cells in mouse liver)
	HEK293T	Normal	Homo sapiens	CVCL_0063
In-vivo Model	Positive ES cell clones were expanded and injected into C57BL/6J blastocysts to generate the chimeric offspring. The chimeric mice were mated with C57BL/6J mice to obtain the lnc-Dpf3 floxed heterozygous mouse (lnc-Dpf3fl/+). The lnc-Dpf3fl/+ mice were bred with C57BL/6J mice expressing the Cre recombinase under the control of the Itgax promoter (Itgax-cre mice; The Jackson Laboratory) to generate lnc-Dpf3 floxed heterozygous mouse with Itgax-cre allele (lnc-Dpf3fl/+Itgax-cre+). These mice were intercrossed to generate DC-specific lnc-Dpf3-deficient mice (lnc-Dpf3fl/flItgax-cre+) used for this study. Hif1afl/fl mice, a kindly gift from Dr. Ming Zhang (Renji Hospital, Medical College of Shanghai Jiaotong University, China) were crossed with Itgax-cre mice to generate DC-specific HIF-1-Alpha-deficient mice (Hif1afl/flItgax-cre+). All mice were maintained under specific pathogen-free conditions and used at 6-8 weeks of age.

In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[3]
Response Summary	YTHDF2 knockdown increases mRNA expression levels of MAP kinase kinase 4 (MAP2K4) and MAP4K4 via stabilizing the mRNA transcripts, which activate MAPK and NF-Kappa-B signaling pathways, which promote the expression of proinflammatory cytokines and aggravate the inflammatory response in LPS-stimulated RAW 264.7 cells.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
In-vitro Model	RAW 264.7	Mouse leukemia	Mus musculus	CVCL_0493

In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene				[1]
Response Summary	METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Mothers against decapentaplegic homolog 7 (SMAD7) and Smurf1 mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	YTH domain-containing family protein 2 (YTHDF2)		READER	Regulator Info
Target Regulation	Down regulation
Pathway Response	MAPK signaling pathway			hsa04010
Cell Process	RNA stability
In-vitro Model	MC3T3-E1	Normal	Mus musculus	CVCL_0409

Ref 1	METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling. Int J Mol Sci. 2019 Dec 27;21(1):199. doi: 10.3390/ijms21010199.
Ref 2	RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):976-981. doi: 10.1073/pnas.1812536116. Epub 2018 Dec 27.
Ref 3	m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response. Int J Mol Sci. 2019 Mar 15;20(6):1323. doi: 10.3390/ijms20061323.
Ref 4	CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1Alpha-Mediated Glycolysis. Immunity. 2019 Mar 19;50(3):600-615.e15. doi: 10.1016/j.immuni.2019.01.021. Epub 2019 Feb 26.