m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00398)
Target Name E3 ubiquitin-protein ligase SMURF1 (SMURF1)
Synonyms
hSMURF1; HECT-type E3 ubiquitin transferase SMURF1; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1; KIAA1625
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Gene Name SMURF1
Chromosomal Location 7q22.1
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Plays a role in dendrite formation by melanocytes .
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Gene ID 57154
Uniprot ID
SMUF1_HUMAN
HGNC ID
HGNC:16807
Ensembl Gene ID
ENSG00000198742; ENSG00000284126
KEGG ID
hsa:57154
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
SMURF1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line HeLa cell line Homo sapiens
Treatment: METTL3 knockdown HeLa cells
Control: HeLa cells
 GSE70061
Regulation
logFC: -1.08E+00
p-value: 3.04E-03
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Smad7 and E3 ubiquitin-protein ligase SMURF1 (SMURF1) mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Target Regulation Down regulation
Responsed Disease Inflammatory response ICD-11: MG46
 Disease Info 
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
YTH domain-containing family protein 2 (YTHDF2) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Smad7 and E3 ubiquitin-protein ligase SMURF1 (SMURF1) mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Target Regulation Down regulation
Responsed Disease Inflammatory response ICD-11: MG46
 Disease Info 
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
Inflammatory response [ICD-11: MG46]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Smad7 and E3 ubiquitin-protein ligase SMURF1 (SMURF1) mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease Inflammatory response [ICD-11: MG46]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 knockdown inhibits osteoblast differentiation and Smad-dependent signaling by stabilizing Smad7 and E3 ubiquitin-protein ligase SMURF1 (SMURF1) mRNA transcripts via YTHDF2 involvement and activates the inflammatory response by regulating MAPK signaling in LPS-induced inflammation.
Responsed Disease Inflammatory response [ICD-11: MG46]
Target Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response MAPK signaling pathway hsa04010
Cell Process RNA stability
In-vitro Model MC3T3-E1 Normal Mus musculus CVCL_0409
References
Ref 1 METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling. Int J Mol Sci. 2019 Dec 27;21(1):199. doi: 10.3390/ijms21010199.