m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01562)

Target Name	ANKRD13C divergent transcript (ANKRD13C-DT)
Synonyms	HHLA3; HERV-H LTR-associating 3 Click to Show/Hide
Gene Name	HERV-H
Chromosomal Location	1p31.1
Gene ID	11147
HGNC ID	HGNC:4906

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: YTH domain-containing protein 2 (YTHDC2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02006		Crosstalk Info
Epigenetic Regulator	Methylcytosine dioxygenase TET1 (TET1)
Regulated Target	Long Terminal Repeat 7 (LTR7)
Crosstalk relationship	m6A → DNA modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02007		Crosstalk Info
Epigenetic Regulator	Methylcytosine dioxygenase TET1 (TET1)
Regulated Target	Long Terminal Repeat 7 (LTR7)
Crosstalk relationship	m6A → DNA modification

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01562)

ANKRD13C divergent transcript (ANKRD13C-DT)

Adenosine-to-Inosine editing (A-to-I)

In total 15 m6A sequence/site(s) in this target gene
mod ID: A2ISITE008922		Click to Show/Hide the Full List
mod site	chr1:70356474-70356475:+		[2]
Sequence	GCGCGGTGGCTTATGCCTGTAATTCCAGCACTTTGGGAGGC
Transcript ID List	ENST00000531950.1; ENST00000370940.6; ENST00000359875.9; ENST00000486110.1; rmsk_159014; ENST00000361764.8; ENST00000463058.5; ENST00000525653.1
External Link	RMBase: RNA-editing_site_6542
mod ID: A2ISITE008923		Click to Show/Hide the Full List
mod site	chr1:70363747-70363748:+		[3]
Sequence	GAAGAGTCAAACTCTGTCAAATATTTGAAGAGATTTCTTCT
Transcript ID List	ENST00000486110.1; ENST00000370940.6; ENST00000361764.8; ENST00000525653.1; ENST00000463058.5; ENST00000531950.1; ENST00000359875.9
External Link	RMBase: RNA-editing_site_6543
mod ID: A2ISITE008924		Click to Show/Hide the Full List
mod site	chr1:70364329-70364330:+		[4]
Sequence	TTGAGTTTGTCTAAAGACCTAGAATTAACAGAAAGGAATGT
Transcript ID List	ENST00000531950.1; ENST00000370940.6; ENST00000359875.9; ENST00000486110.1; ENST00000463058.5; ENST00000361764.8; ENST00000525653.1
External Link	RMBase: RNA-editing_site_6544
mod ID: A2ISITE008926		Click to Show/Hide the Full List
mod site	chr1:70364448-70364449:+		[3]
Sequence	GAGAATGTAAAATGTTTCTTATCAGACTTAAAGTCTGTGCT
Transcript ID List	ENST00000525653.1; ENST00000361764.8; ENST00000486110.1; ENST00000370940.6; ENST00000359875.9; ENST00000531950.1; ENST00000463058.5
External Link	RMBase: RNA-editing_site_6545
mod ID: A2ISITE008928		Click to Show/Hide the Full List
mod site	chr1:70364554-70364555:+		[4]
Sequence	AGTCTCTGCAGTTAAATTTTAAAAGAGCCGTGAATGAGGAG
Transcript ID List	ENST00000370940.6; ENST00000525653.1; ENST00000359875.9; ENST00000531950.1; ENST00000463058.5; ENST00000486110.1; ENST00000361764.8
External Link	RMBase: RNA-editing_site_6546
mod ID: A2ISITE008929		Click to Show/Hide the Full List
mod site	chr1:70364555-70364556:+		[4]
Sequence	GTCTCTGCAGTTAAATTTTAAAAGAGCCGTGAATGAGGAGG
Transcript ID List	ENST00000486110.1; ENST00000359875.9; ENST00000361764.8; ENST00000463058.5; ENST00000525653.1; ENST00000531950.1; ENST00000370940.6
External Link	RMBase: RNA-editing_site_6547
mod ID: A2ISITE008930		Click to Show/Hide the Full List
mod site	chr1:70364612-70364613:+		[3]
Sequence	ACGGTTGGAAGGGGGATCTTAGAATTTTATTTTTGGTTTAT
Transcript ID List	ENST00000525653.1; ENST00000359875.9; ENST00000370940.6; ENST00000463058.5; ENST00000486110.1; ENST00000531950.1; ENST00000361764.8
External Link	RMBase: RNA-editing_site_6548
mod ID: A2ISITE008931		Click to Show/Hide the Full List
mod site	chr1:70364827-70364828:+		[3]
Sequence	ATATACAACAACTTTTTAGTATAAGTGTATCCCAAATAGGA
Transcript ID List	ENST00000463058.5; ENST00000370940.6; rmsk_159034; ENST00000525653.1; ENST00000486110.1; ENST00000359875.9; ENST00000531950.1; ENST00000361764.8
External Link	RMBase: RNA-editing_site_6549
mod ID: A2ISITE008932		Click to Show/Hide the Full List
mod site	chr1:70365288-70365289:+		[3]
Sequence	ACTTCTGTAAACCAAAAATAAAATTGTAAAGCCCCCCAATC
Transcript ID List	ENST00000359875.9; rmsk_159038; ENST00000463058.5; ENST00000525653.1; ENST00000370940.6; ENST00000486110.1; ENST00000361764.8; ENST00000531950.1
External Link	RMBase: RNA-editing_site_6550
mod ID: A2ISITE008933		Click to Show/Hide the Full List
mod site	chr1:70365737-70365738:+		[3]
Sequence	CATGATACCTCTCAGGCATTAACATCAACACAGATCTTAAA
Transcript ID List	ENST00000463058.5; ENST00000531950.1; ENST00000486110.1; ENST00000525653.1; ENST00000359875.9; ENST00000361764.8; rmsk_159040; ENST00000370940.6
External Link	RMBase: RNA-editing_site_6551
mod ID: A2ISITE008934		Click to Show/Hide the Full List
mod site	chr1:70365740-70365741:+		[3]
Sequence	GATACCTCTCAGGCATTAACATCAACACAGATCTTAAATCT
Transcript ID List	ENST00000486110.1; rmsk_159040; ENST00000361764.8; ENST00000359875.9; ENST00000463058.5; ENST00000525653.1; ENST00000370940.6; ENST00000531950.1
External Link	RMBase: RNA-editing_site_6552
mod ID: A2ISITE008935		Click to Show/Hide the Full List
mod site	chr1:70365862-70365863:+		[3]
Sequence	AAGCCAGACATTTCCTTTCTATTGATCCCAGGTATTTAGAT
Transcript ID List	ENST00000531950.1; ENST00000463058.5; ENST00000370940.6; ENST00000361764.8; ENST00000359875.9; rmsk_159040; ENST00000486110.1; ENST00000525653.1
External Link	RMBase: RNA-editing_site_6553
mod ID: A2ISITE008938		Click to Show/Hide the Full List
mod site	chr1:70365991-70365992:+		[3]
Sequence	ACAATGTATTTCTTAAATGTATTTGATTAATGTCCCATGTC
Transcript ID List	ENST00000370940.6; rmsk_159040; ENST00000359875.9; ENST00000486110.1; ENST00000361764.8; ENST00000531950.1; ENST00000463058.5; ENST00000525653.1
External Link	RMBase: RNA-editing_site_6554
mod ID: A2ISITE008939		Click to Show/Hide the Full List
mod site	chr1:70366033-70366034:+		[3]
Sequence	CCCTAAAATGAGTAAAACCAAGCTGCTCCCGGACCACCTGA
Transcript ID List	ENST00000486110.1; ENST00000359875.9; rmsk_159040; ENST00000361764.8; ENST00000463058.5; ENST00000370940.6; ENST00000525653.1; ENST00000531950.1
External Link	RMBase: RNA-editing_site_6555
mod ID: A2ISITE008940		Click to Show/Hide the Full List
mod site	chr1:70366053-70366054:+		[3]
Sequence	AGCTGCTCCCGGACCACCTGAGACACATGTTCTCAGGGCCT
Transcript ID List	ENST00000359875.9; ENST00000486110.1; ENST00000361764.8; ENST00000370940.6; ENST00000463058.5; ENST00000525653.1; ENST00000531950.1; rmsk_159040
External Link	RMBase: RNA-editing_site_6556

N6-methyladenosine (m6A)

In total 16 m6A sequence/site(s) in this target gene
mod ID: M6ASITE031802		Click to Show/Hide the Full List
mod site	chr1:70354890-70354891:+		[5]
Sequence	CAGCTGCCAGCCGACCCCGAACCCGCACTCCCGCCAACCGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; hESCs; fibroblasts; A549; MM6; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000525653.1; ENST00000486110.1; ENST00000531950.1; ENST00000361764.8; ENST00000463058.5; ENST00000370940.6; ENST00000359875.9
External Link	RMBase: m6A_site_35828
mod ID: M6ASITE031803		Click to Show/Hide the Full List
mod site	chr1:70354932-70354933:+		[5]
Sequence	CTTTTTGTGGGCGGTCGGAAACCACAGCCTCCGTTGGATAT
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; fibroblasts; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370940.6; ENST00000463058.5; ENST00000361764.8; ENST00000531950.1; ENST00000359875.9; ENST00000525653.1; ENST00000486110.1
External Link	RMBase: m6A_site_35829
mod ID: M6ASITE031804		Click to Show/Hide the Full List
mod site	chr1:70354971-70354972:+		[6]
Sequence	ATGTTCGGTGCATGTTATAAACAACCACTTAAACCCTCCGG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T; HeLa; Jurkat; CD4T; GSC-11; HEK293A-TOA; iSLK; TIME; MSC; endometrial; HEC-1-A
Seq Type List	MAZTER-seq; m6A-seq; MeRIP-seq
Transcript ID List	ENST00000370940.6; ENST00000486110.1; ENST00000531950.1; ENST00000525653.1; ENST00000463058.5; ENST00000359875.9; ENST00000361764.8
External Link	RMBase: m6A_site_35830
mod ID: M6ASITE031805		Click to Show/Hide the Full List
mod site	chr1:70354983-70354984:+		[7]
Sequence	TGTTATAAACAACCACTTAAACCCTCCGGATCTGAGCCTCC
Motif Score	2.185083333
Cell/Tissue List	CD4T; iSLK; MSC; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000359875.9; ENST00000531950.1; ENST00000361764.8; ENST00000525653.1; ENST00000463058.5; ENST00000486110.1; ENST00000370940.6
External Link	RMBase: m6A_site_35831
mod ID: M6ASITE031806		Click to Show/Hide the Full List
mod site	chr1:70355080-70355081:+		[6]
Sequence	AGAGGATACTCAGTCAACCAACATTTACTGAGCATCTACTT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000486110.1; ENST00000370940.6; ENST00000359875.9; ENST00000531950.1; ENST00000361764.8; ENST00000463058.5; ENST00000525653.1
External Link	RMBase: m6A_site_35832
mod ID: M6ASITE031807		Click to Show/Hide the Full List
mod site	chr1:70355184-70355185:+		[8]
Sequence	AGAAGAGGAATGAAGGCCAAACAATTAAAAGCGGAGGCGGG
Motif Score	2.20572619
Cell/Tissue List	MT4
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000370940.6; ENST00000531950.1; ENST00000361764.8; ENST00000525653.1; ENST00000359875.9; ENST00000463058.5; ENST00000486110.1
External Link	RMBase: m6A_site_35833
mod ID: M6ASITE031808		Click to Show/Hide the Full List
mod site	chr1:70366978-70366979:+		[5]
Sequence	GGTGCACCCTTACAGATCAAACAATGGTAAGCGCTCATTTG
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000361764.8; ENST00000525653.1; ENST00000463058.5; ENST00000531950.1; ENST00000370940.6; ENST00000359875.9
External Link	RMBase: m6A_site_35838
mod ID: M6ASITE031809		Click to Show/Hide the Full List
mod site	chr1:70367634-70367635:+		[5]
Sequence	AGCTTAGTGATGTGTGTCAGACCTCTGAGCCCAAGCAAAGC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	rmsk_159046; ENST00000370940.6; ENST00000531950.1; ENST00000525653.1; ENST00000361764.8; ENST00000463058.5; ENST00000359875.9
External Link	RMBase: m6A_site_35839
mod ID: M6ASITE031810		Click to Show/Hide the Full List
mod site	chr1:70367683-70367684:+		[6]
Sequence	CCCCTGTGACCTGCATGTATACATCCAGATGGCCTGAAGCA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000359875.9; ENST00000361764.8; ENST00000370940.6; ENST00000531950.1; ENST00000463058.5; rmsk_159046; ENST00000525653.1
External Link	RMBase: m6A_site_35840
mod ID: M6ASITE031811		Click to Show/Hide the Full List
mod site	chr1:70367715-70367716:+		[6]
Sequence	CCTGAAGCAAGTGAAGAATCACAAAAGAAGTGAAAAGGGCC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000370940.6; ENST00000361764.8; ENST00000531950.1; ENST00000359875.9; ENST00000525653.1; rmsk_159046; ENST00000463058.5
External Link	RMBase: m6A_site_35841
mod ID: M6ASITE031812		Click to Show/Hide the Full List
mod site	chr1:70367756-70367757:+		[6]
Sequence	GGTTCCTGCCTTAACTGATGACATTCCACCATTGTGATTTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000531950.1; rmsk_159046; ENST00000361764.8; ENST00000370940.6; ENST00000359875.9; ENST00000463058.5
External Link	RMBase: m6A_site_35842
mod ID: M6ASITE031813		Click to Show/Hide the Full List
mod site	chr1:70367793-70367794:+		[9]
Sequence	TTTGTTCCTGCCCCACCTTAACTGAGCGATTAACCTGTGAA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	rmsk_159046; ENST00000370940.6; ENST00000463058.5; ENST00000531950.1; ENST00000361764.8; ENST00000359875.9
External Link	RMBase: m6A_site_35843
mod ID: M6ASITE031814		Click to Show/Hide the Full List
mod site	chr1:70367813-70367814:+		[5]
Sequence	ACTGAGCGATTAACCTGTGAACTTCCTTCTCCTGGCTCAGA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; hESCs; fibroblasts; A549; MM6; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000359875.9; ENST00000370940.6; ENST00000463058.5; rmsk_159046; ENST00000361764.8; ENST00000531950.1
External Link	RMBase: m6A_site_35844
mod ID: M6ASITE031815		Click to Show/Hide the Full List
mod site	chr1:70367882-70367883:+		[5]
Sequence	CCGCCCCTGCCTGCCATAGAACAACCCCCTTTGATTGTAAT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; fibroblasts; A549; LCLs; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000359875.9; ENST00000463058.5; ENST00000361764.8; rmsk_159046; ENST00000370940.6; ENST00000531950.1
External Link	RMBase: m6A_site_35845
mod ID: M6ASITE031816		Click to Show/Hide the Full List
mod site	chr1:70367959-70367960:+		[9]
Sequence	ACCCCTATCTCCCTTCGCTGACACTCTCTTTGGACTCAGCC
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000370940.6; ENST00000463058.5; rmsk_159046; ENST00000531950.1; ENST00000359875.9
External Link	RMBase: m6A_site_35846
mod ID: M6ASITE031817		Click to Show/Hide the Full List
mod site	chr1:70367972-70367973:+		[5]
Sequence	TTCGCTGACACTCTCTTTGGACTCAGCCTGCCTGCACCTAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; LCLs; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000463058.5; ENST00000359875.9; ENST00000370940.6; rmsk_159046; ENST00000531950.1
External Link	RMBase: m6A_site_35847

Ref 1	IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45. doi: 10.1007/s00428-003-0856-5. Epub 2003 Jul 5.
Ref 2	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 3	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 4	Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Nat Biotechnol. 2012 Feb 12;30(3):253-60. doi: 10.1038/nbt.2122.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife. 2016 Jul 2;5:e15528. doi: 10.7554/eLife.15528.
Ref 8	Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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