m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01408)

Target Name	Acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3)
Synonyms	EC 6.2.1.1; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.17 Click to Show/Hide
Gene Name	ACSS3
Chromosomal Location	12q21.31
Family	ATP-dependent AMP-binding enzyme family
Function	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate (PubMed:28003429). Can utilize acetate and butyrate with a much lower affinity (By similarity). Click to Show/Hide
Gene ID	79611
Uniprot ID	ACSS3_HUMAN
HGNC ID	HGNC:24723
KEGG ID	hsa:79611

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 9 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03077		Crosstalk Info
Regulated Target	Histone H3 lysine 14 propionylation (H3K14pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT03078		Crosstalk Info
Regulated Target	Histone H3 lysine 23 propionylation (H3k23pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT03481		Crosstalk Info
Epigenetic Regulator	Lactate dehydrogenase A (LDHA)
Regulated Target	Histone H3 lysine 18 lactylation (H3K18lac)
Crosstalk relationship	Histone modification → m6A
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT05838		Crosstalk Info
Regulated Target	Histone H3 lysine 14 propionylation (H3K14pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT05839		Crosstalk Info
Regulated Target	Histone H3 lysine 14 propionylation (H3K14pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT05840		Crosstalk Info
Regulated Target	Histone H3 lysine 14 propionylation (H3K14pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT05841		Crosstalk Info
Regulated Target	Histone H3 lysine 23 propionylation (H3k23pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT05842		Crosstalk Info
Regulated Target	Histone H3 lysine 23 propionylation (H3k23pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info
Crosstalk ID: M6ACROT05843		Crosstalk Info
Regulated Target	Histone H3 lysine 23 propionylation (H3k23pr)
Crosstalk relationship	m6A → Histone modification
Disease	Nonalcoholic fatty liver disease	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR01408)

Acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3)

Adenosine-to-Inosine editing (A-to-I)

In total 8 m6A sequence/site(s) in this target gene
mod ID: A2ISITE005713		Click to Show/Hide the Full List
mod site	chr12:81081906-81081907:+		[2]
Sequence	ATTCCTTACTAGCTGAGATTAAGGTTGTTTAATCCTGCCAA
Transcript ID List	ENST00000548058.6; ENST00000549175.1; ENST00000261206.7
External Link	RMBase: RNA-editing_site_30364
mod ID: A2ISITE005714		Click to Show/Hide the Full List
mod site	chr12:81183025-81183026:+		[2]
Sequence	TTTTAACTGGCAAAGGGTCCAGCTGCTCACTGCTTGTAGAA
Transcript ID List	ENST00000548324.5; ENST00000546664.2; ENST00000548058.6; ENST00000261206.7; ENST00000551745.1; rmsk_3843116
External Link	RMBase: RNA-editing_site_30365
mod ID: A2ISITE005715		Click to Show/Hide the Full List
mod site	chr12:81183174-81183175:+		[2]
Sequence	TCCCCGTGTTAGCACAGACAATTAAAACTCCTCTCTTTTTA
Transcript ID List	ENST00000261206.7; ENST00000548058.6; ENST00000548324.5; ENST00000546664.2; ENST00000551745.1; rmsk_3843116
External Link	RMBase: RNA-editing_site_30366
mod ID: A2ISITE005716		Click to Show/Hide the Full List
mod site	chr12:81239797-81239798:+		[2]
Sequence	ACCGTATCAGAAAGTAAAATAAAACATTTTAATTTTCTTGT
Transcript ID List	rmsk_3843199; ENST00000548324.5; ENST00000261206.7; ENST00000548058.6
External Link	RMBase: RNA-editing_site_30367
mod ID: A2ISITE005717		Click to Show/Hide the Full List
mod site	chr12:81239800-81239801:+		[2]
Sequence	GTATCAGAAAGTAAAATAAAACATTTTAATTTTCTTGTTCT
Transcript ID List	ENST00000548058.6; ENST00000548324.5; ENST00000261206.7; rmsk_3843199
External Link	RMBase: RNA-editing_site_30368
mod ID: A2ISITE005718		Click to Show/Hide the Full List
mod site	chr12:81243750-81243751:+		[2]
Sequence	ACAAATAGCAAAATATTTCTAATTCCTCCCTTGTAGCTCTT
Transcript ID List	ENST00000548058.6; ENST00000548324.5; ENST00000261206.7
External Link	RMBase: RNA-editing_site_30369
mod ID: A2ISITE005719		Click to Show/Hide the Full List
mod site	chr12:81243751-81243752:+		[2]
Sequence	CAAATAGCAAAATATTTCTAATTCCTCCCTTGTAGCTCTTG
Transcript ID List	ENST00000548324.5; ENST00000261206.7; ENST00000548058.6
External Link	RMBase: RNA-editing_site_30370
mod ID: A2ISITE005720		Click to Show/Hide the Full List
mod site	chr12:81243840-81243841:+		[2]
Sequence	CATATACACACATTGTTGCTATTATTATTTTGAACAAACTT
Transcript ID List	ENST00000548324.5; ENST00000261206.7; ENST00000548058.6
External Link	RMBase: RNA-editing_site_30371

N6-methyladenosine (m6A)

In total 18 m6A sequence/site(s) in this target gene
mod ID: M6ASITE014447		Click to Show/Hide the Full List
mod site	chr12:80936719-80936720:+		[3]
Sequence	GGCCCCGATCGCAGCGGAGGACTCCATCCCTGAGCTTGTGA
Motif Score	4.065041667
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200613
mod ID: M6ASITE014448		Click to Show/Hide the Full List
mod site	chr12:80936762-80936763:+		[3]
Sequence	GCGTCCTGGGGAGGAAGCGAACACTTTCCCCGTTCAAGTCA
Motif Score	2.951386905
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200614
mod ID: M6ASITE014449		Click to Show/Hide the Full List
mod site	chr12:80936792-80936793:+		[3]
Sequence	CGTTCAAGTCAGAGAGCAGGACTCACTGGGTGGCAGGTCAG
Motif Score	4.065041667
Cell/Tissue List	H1A; H1B
Seq Type List	m6A-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200615
mod ID: M6ASITE014450		Click to Show/Hide the Full List
mod site	chr12:80936895-80936896:+		[4]
Sequence	TGGCACCGAGCTGGGAGAGGACACGAGAGGCTGGCGCGGGA
Motif Score	3.643047619
Cell/Tissue List	HepG2; H1B; H1A
Seq Type List	m6A-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200616
mod ID: M6ASITE014451		Click to Show/Hide the Full List
mod site	chr12:80937146-80937147:+		[5]
Sequence	CCCCCCGAGTGGCCGCCGGGACTCCAGCAGTTGGACCGACC
Motif Score	4.065041667
Cell/Tissue List	HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200617
mod ID: M6ASITE014452		Click to Show/Hide the Full List
mod site	chr12:80937160-80937161:+		[5]
Sequence	GCCGGGACTCCAGCAGTTGGACCGACCCTCGCCCTCCGGCG
Motif Score	3.622404762
Cell/Tissue List	HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200618
mod ID: M6ASITE014453		Click to Show/Hide the Full List
mod site	chr12:80937186-80937187:+		[3]
Sequence	CCTCGCCCTCCGGCGCCTGGACAAACTTCCTTCCTCCCGGG
Motif Score	3.643047619
Cell/Tissue List	H1A; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200619
mod ID: M6ASITE014454		Click to Show/Hide the Full List
mod site	chr12:80937353-80937354:+		[4]
Sequence	GGCTCCAACAAAGCCAGAGGACCGGAGACGACCCGGCGAGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; H1A; H1B; HEK293T; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200620
mod ID: M6ASITE014455		Click to Show/Hide the Full List
mod site	chr12:80937394-80937395:+		[4]
Sequence	GGCTGGGAGTGGCAGCGGGGACCCCAGAGCCAGAAGGAGGC
Motif Score	3.622404762
Cell/Tissue List	HepG2; H1A; H1B; HEK293T; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200621
mod ID: M6ASITE014456		Click to Show/Hide the Full List
mod site	chr12:80937663-80937664:+		[6]
Sequence	TGTCCAGGGTGAGCGGCTGGACCACTGTCAATGTCGCCATG
Motif Score	3.622404762
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000616449.1
External Link	RMBase: m6A_site_200622
mod ID: M6ASITE014457		Click to Show/Hide the Full List
mod site	chr12:81078125-81078126:+		[7]
Sequence	GGGTGGCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCG
Motif Score	2.185083333
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000548058.6; ENST00000261206.7; ENST00000549175.1
External Link	RMBase: m6A_site_200624
mod ID: M6ASITE014458		Click to Show/Hide the Full List
mod site	chr12:81078309-81078310:+		[4]
Sequence	GCAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTCGGTG
Motif Score	2.876744048
Cell/Tissue List	HepG2; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000548058.6; ENST00000261206.7; ENST00000549175.1
External Link	RMBase: m6A_site_200625
mod ID: M6ASITE014459		Click to Show/Hide the Full List
mod site	chr12:81078390-81078391:+		[8]
Sequence	TCAGCTGGTACAAGCCCTGGACCAAAACGCTGGAGAACAAA
Motif Score	3.622404762
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000549175.1; ENST00000261206.7; ENST00000548058.6
External Link	RMBase: m6A_site_200626
mod ID: M6ASITE014460		Click to Show/Hide the Full List
mod site	chr12:81078406-81078407:+		[7]
Sequence	CTGGACCAAAACGCTGGAGAACAAACACTCGCCCTCTACCA
Motif Score	2.951386905
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000261206.7; ENST00000548058.6; ENST00000549175.1
External Link	RMBase: m6A_site_200627
mod ID: M6ASITE014461		Click to Show/Hide the Full List
mod site	chr12:81109588-81109589:+		[9]
Sequence	AGGAATGCTTAACATTTGTTACAATGCCGTTGATCGTCATA
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000549175.1; ENST00000261206.7; ENST00000548058.6
External Link	RMBase: m6A_site_200628
mod ID: M6ASITE014462		Click to Show/Hide the Full List
mod site	chr12:81109648-81109649:+		[10]
Sequence	TAAGATTGCTATCATCTATGACAGTCCTGTTACAAACACTA
Motif Score	2.859755952
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000261206.7; ENST00000548058.6; ENST00000549175.1
External Link	RMBase: m6A_site_200629
mod ID: M6ASITE014463		Click to Show/Hide the Full List
mod site	chr12:81143171-81143172:+		[10]
Sequence	GAGATGGCAAAAGCCCAGTCACATGACTGTGTTCCTGTTCT
Motif Score	2.047297619
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000261206.7; ENST00000548387.1; ENST00000548058.6
External Link	RMBase: m6A_site_200630
mod ID: M6ASITE014464		Click to Show/Hide the Full List
mod site	chr12:81255371-81255372:+		[10]
Sequence	CTAGTATTCTTTAGATGCTCACATTGTTTTAAATAAAATAG
Motif Score	2.047297619
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000548058.6; ENST00000548324.5; ENST00000261206.7
External Link	RMBase: m6A_site_200631

Ref 1	Serdemetan antagonizes the Mdm2-HIF1Alpha axis leading to decreased levels of glycolytic enzymes. PLoS One. 2013 Sep 6;8(9):e74741. doi: 10.1371/journal.pone.0074741. eCollection 2013.
Ref 2	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 3	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 4	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 5	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 6	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 7	[Action myoclonias and paranoid alternative psychosis in progressive myoclonic epilepsy (late form of the Lafora type)]. Nervenarzt. 1986 Apr;57(4):233-7.
Ref 8	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 9	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 10	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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