m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00871)

Target Name	GNAS antisense RNA 1 (GNAS-AS1)
Synonyms	SANG; NESP-AS; NESPAS; GNAS1AS; NCRNA00075; GNAS antisense; GNASAS; GNAS antisense RNA (non-protein coding) Click to Show/Hide
Gene Name	GNAS-AS1
Chromosomal Location	20q13.32
Gene ID	149775
HGNC ID	HGNC:24872

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: Wilms tumor 1-associating protein (WTAP)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02275		Crosstalk Info
Regulated Target	hsa-miR-550-1
Crosstalk relationship	DNA modification → m6A
Disease	Acute myeloid leukaemia	Disease Info
Drug	Chidamide	Drug Info

Non-coding RNA

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05289		Crosstalk Info
Epigenetic Regulator	hsa-miR-34a-5p
Regulated Target	Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship	ncRNA → m6A
Disease	Breast cancer	Disease Info
Drug	Tamoxifen	Drug Info
Crosstalk ID: M6ACROT05291		Crosstalk Info
Epigenetic Regulator	GNAS antisense RNA 1 (GNAS-AS1)
Regulated Target	hsa-miR-34a-5p
Crosstalk relationship	ncRNA → m6A
Disease	Breast cancer	Disease Info
Drug	Tamoxifen	Drug Info

m6A Regulator: Wilms tumor 1-associating protein (WTAP)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05668		Crosstalk Info
Epigenetic Regulator	GNAS antisense RNA 1 (GNAS-AS1)
Regulated Target	hsa-miR-34a-5p
Crosstalk relationship	m6A → ncRNA
Disease	Acute myeloid leukaemia	Disease Info
Drug	Chidamide	Drug Info
Crosstalk ID: M6ACROT05928		Crosstalk Info
Epigenetic Regulator	hsa-miR-34a-5p
Regulated Target	Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship	m6A → ncRNA
Disease	Acute myeloid leukaemia	Disease Info
Drug	Chidamide	Drug Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00871)

GNAS antisense RNA 1 (GNAS-AS1)

N6-methyladenosine (m6A)

In total 26 m6A sequence/site(s) in this target gene
mod ID: M6ASITE053985		Click to Show/Hide the Full List
mod site	chr20:58819034-58819035:-		[2]
Sequence	ATCTCTGACGTCCGCTGGGAACTGGCTGCTCTGCAGGTTTC
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000424094.6
External Link	RMBase: m6A_site_538634
mod ID: M6ASITE053986		Click to Show/Hide the Full List
mod site	chr20:58834499-58834500:-		[2]
Sequence	TTCTCCGGTTCAGACCCTGGACTCTGACACCCTGCCTTGCT
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6; ENST00000443966.2; ENST00000631314.2; ENST00000601795.1
External Link	RMBase: m6A_site_538635
mod ID: M6ASITE053987		Click to Show/Hide the Full List
mod site	chr20:58834506-58834507:-		[2]
Sequence	TTCTGTATTCTCCGGTTCAGACCCTGGACTCTGACACCCTG
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000424094.6; ENST00000631314.2; ENST00000601795.1; ENST00000443966.2; ENST00000598163.1
External Link	RMBase: m6A_site_538636
mod ID: M6ASITE053988		Click to Show/Hide the Full List
mod site	chr20:58834651-58834652:-		[2]
Sequence	ACAGGAGGAGCAATTTCTAGACTCTGGATCCAACGGGAAGC
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000631314.2; ENST00000443966.2; ENST00000424094.6; ENST00000601795.1; ENST00000598163.1
External Link	RMBase: m6A_site_538637
mod ID: M6ASITE053989		Click to Show/Hide the Full List
mod site	chr20:58836239-58836240:-		[2]
Sequence	AAGCAATGTGAAGTCAAAGGACAGGTAACCACACACTGGAG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000601795.1; ENST00000424094.6; rmsk_5164540; ENST00000443966.2; ENST00000631314.2; ENST00000598163.1
External Link	RMBase: m6A_site_538638
mod ID: M6ASITE053990		Click to Show/Hide the Full List
mod site	chr20:58839698-58839699:-		[2]
Sequence	CTGCGAAGTTGCGCGCCCGGACTTCTGCCGGGCATGTGCAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; hESCs; fibroblasts
Seq Type List	m6A-seq
Transcript ID List	ENST00000443966.2; ENST00000631314.2; ENST00000424094.6; ENST00000598163.1
External Link	RMBase: m6A_site_538639
mod ID: M6ASITE053992		Click to Show/Hide the Full List
mod site	chr20:58839749-58839750:-		[2]
Sequence	CCTGGGAGAGGACAGAGGAGACTGAGGCGAGGAGGGACGGG
Motif Score	3.319380952
Cell/Tissue List	HeLa; H1A; H1B; hESCs; fibroblasts; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000631314.2; ENST00000443966.2; ENST00000424094.6; ENST00000598163.1
External Link	RMBase: m6A_site_538641
mod ID: M6ASITE053993		Click to Show/Hide the Full List
mod site	chr20:58839758-58839759:-		[2]
Sequence	GTCCTCTTGCCTGGGAGAGGACAGAGGAGACTGAGGCGAGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; H1A; H1B; hESCs; fibroblasts; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000631314.2; ENST00000424094.6; ENST00000443966.2
External Link	RMBase: m6A_site_538642
mod ID: M6ASITE053995		Click to Show/Hide the Full List
mod site	chr20:58839801-58839802:-		[2]
Sequence	CTTAGATTCCGCAGCCTAAGACTCGAGAGAGGTGCCTCCGC
Motif Score	3.319380952
Cell/Tissue List	HeLa; H1A; H1B; hNPCs; hESCs; fibroblasts; GSC-11; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000443966.2; ENST00000424094.6; ENST00000631314.2
External Link	RMBase: m6A_site_538644
mod ID: M6ASITE053999		Click to Show/Hide the Full List
mod site	chr20:58839921-58839922:-		[3]
Sequence	ACCTTCCTGACCACTTAAGAACTTTCTAAAGCTCCGCGCCT
Motif Score	3.373380952
Cell/Tissue List	H1A; H1B; GSC-11; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000631314.2; ENST00000443966.2; ENST00000424094.6; ENST00000598163.1
External Link	RMBase: m6A_site_538648
mod ID: M6ASITE054001		Click to Show/Hide the Full List
mod site	chr20:58840340-58840341:-		[2]
Sequence	GTCAGATTCCGATTCGGGGGACTCAGGGAATACCTGGGCGC
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000424094.6; ENST00000598163.1; ENST00000443966.2
External Link	RMBase: m6A_site_538650
mod ID: M6ASITE054003		Click to Show/Hide the Full List
mod site	chr20:58840391-58840392:-		[2]
Sequence	CTCTAGGCACTCGGGGAGGGACAGCTCAAGGTCTGCCTCCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6; ENST00000443966.2
External Link	RMBase: m6A_site_538652
mod ID: M6ASITE054004		Click to Show/Hide the Full List
mod site	chr20:58840424-58840425:-		[2]
Sequence	GCTCTCGGTCTCGTAGTCGAACTCTTCCTCGTACTCTAGGC
Motif Score	3.373380952
Cell/Tissue List	HeLa; H1B; GSC-11; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000443966.2; ENST00000424094.6; ENST00000598163.1
External Link	RMBase: m6A_site_538653
mod ID: M6ASITE054007		Click to Show/Hide the Full List
mod site	chr20:58840454-58840455:-		[2]
Sequence	GGTCTCGGACTCGATTTCGGACTCGGTCTCGCTCTCGGTCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; GSC-11; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6; ENST00000443966.2
External Link	RMBase: m6A_site_538656
mod ID: M6ASITE054008		Click to Show/Hide the Full List
mod site	chr20:58840466-58840467:-		[2]
Sequence	GGTCTCGAAGTCGGTCTCGGACTCGATTTCGGACTCGGTCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; GSC-11; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000443966.2; ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538657
mod ID: M6ASITE054013		Click to Show/Hide the Full List
mod site	chr20:58840577-58840578:-		[2]
Sequence	GTGCAGACGCTGGGTGAGGGACTGGCCGAAGGTGGAGTGCT
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; GSC-11; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000443966.2; ENST00000424094.6
External Link	RMBase: m6A_site_538662
mod ID: M6ASITE054016		Click to Show/Hide the Full List
mod site	chr20:58840802-58840803:-		[2]
Sequence	GGGTCCCTTTTTGGAAGGGGACTCCGGGGACGCGTCACGGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; hNPCs; hESCs; GSC-11; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6; ENST00000443966.2
External Link	RMBase: m6A_site_538665
mod ID: M6ASITE054022		Click to Show/Hide the Full List
mod site	chr20:58841998-58841999:-		[2]
Sequence	CGACGACTGATCGTCCAAGGACTGGCGCCGGATCCAACACC
Motif Score	4.065041667
Cell/Tissue List	HeLa; H1A; H1B; HEK293T; GSCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000424094.6; ENST00000598163.1
External Link	RMBase: m6A_site_538671
mod ID: M6ASITE054023		Click to Show/Hide the Full List
mod site	chr20:58842110-58842111:-		[4]
Sequence	CCCTCCAGGTTACAGATTAAACTTAACTCTACCCGTGCTGA
Motif Score	2.627720238
Cell/Tissue List	hESCs
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538672
mod ID: M6ASITE054024		Click to Show/Hide the Full List
mod site	chr20:58842495-58842496:-		[2]
Sequence	CTGCGCTGCAGCCCGGCAGAACTAAGTCTTGGGCGCCGCGA
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538673
mod ID: M6ASITE054025		Click to Show/Hide the Full List
mod site	chr20:58842539-58842540:-		[2]
Sequence	CTCCGTATTTACTAGGGAAGACCACAAAAGCATCCAACCAC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538674
mod ID: M6ASITE054026		Click to Show/Hide the Full List
mod site	chr20:58848892-58848893:-		[2]
Sequence	TGGCTACCAGACTCTGAAAAACCTAAGTCCTTTAGGTGAGT
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000424094.6; ENST00000598163.1
External Link	RMBase: m6A_site_538675
mod ID: M6ASITE054027		Click to Show/Hide the Full List
mod site	chr20:58848902-58848903:-		[2]
Sequence	CTGTAGTGACTGGCTACCAGACTCTGAAAAACCTAAGTCCT
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538676
mod ID: M6ASITE054028		Click to Show/Hide the Full List
mod site	chr20:58850616-58850617:-		[2]
Sequence	CTGGGAGGTAGAGGGCCAGGACCCCAAGGAGAGGGCTTACT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538677
mod ID: M6ASITE054029		Click to Show/Hide the Full List
mod site	chr20:58850802-58850803:-		[2]
Sequence	AGGCCTGGAAGACCACGAGGACCGCTAGCGCCGTGGGGTCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; MM6; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538678
mod ID: M6ASITE054030		Click to Show/Hide the Full List
mod site	chr20:58850811-58850812:-		[2]
Sequence	ATGGCGGCTAGGCCTGGAAGACCACGAGGACCGCTAGCGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq
Transcript ID List	ENST00000598163.1; ENST00000424094.6
External Link	RMBase: m6A_site_538679

Ref 1	MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene. 2011 Jan 6;30(1):117-26. doi: 10.1038/onc.2010.403. Epub 2010 Sep 6.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 4	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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