m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00823)

Target Name	CCN family member 2 (CTGF)
Synonyms	Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8 Click to Show/Hide
Gene Name	CTGF
Chromosomal Location	6q23.2
Family	CCN family
Function	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Click to Show/Hide
Gene ID	1490
Uniprot ID	CCN2_HUMAN
HGNC ID	HGNC:2500
KEGG ID	hsa:1490

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Non-coding RNA

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05184		Crosstalk Info
Epigenetic Regulator	AI662270
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	ncRNA → m6A
Disease	Chronic kidney disease	Disease Info

m6A Regulator: Methyltransferase-like 14 (METTL14)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05185		Crosstalk Info
Epigenetic Regulator	AI662270
Regulated Target	Methyltransferase-like protein 14 (METTL14)
Crosstalk relationship	ncRNA → m6A
Disease	Chronic kidney disease	Disease Info

m6A Regulator: Wilms tumor 1-associating protein (WTAP)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05186		Crosstalk Info
Epigenetic Regulator	AI662270
Regulated Target	Pre-mRNA-splicing regulator WTAP (WTAP)
Crosstalk relationship	ncRNA → m6A
Disease	Chronic kidney disease	Disease Info

m6A Regulator: Protein virilizer homolog (VIRMA)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05187		Crosstalk Info
Epigenetic Regulator	AI662270
Regulated Target	Protein virilizer homolog (VIRMA)
Crosstalk relationship	ncRNA → m6A
Disease	Chronic kidney disease	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00823)

CCN family member 2 (CTGF)

N6-methyladenosine (m6A)

In total 29 m6A sequence/site(s) in this target gene
mod ID: M6ASITE077041		Click to Show/Hide the Full List
mod site	chr6:131948727-131948728:-		[4]
Sequence	AATCCTGTCGATTAGACTGGACAGCTTGTGGCAAGTGAATT
Motif Score	3.643047619
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734081
mod ID: M6ASITE077042		Click to Show/Hide the Full List
mod site	chr6:131948732-131948733:-		[4]
Sequence	ATCGGAATCCTGTCGATTAGACTGGACAGCTTGTGGCAAGT
Motif Score	3.319380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734082
mod ID: M6ASITE077043		Click to Show/Hide the Full List
mod site	chr6:131948793-131948794:-		[4]
Sequence	TCCTTAAGTCAGAACAGCAGACTCAGCTCTGACATTCTGAT
Motif Score	3.319380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734083
mod ID: M6ASITE077044		Click to Show/Hide the Full List
mod site	chr6:131948800-131948801:-		[4]
Sequence	AAGTTGTTCCTTAAGTCAGAACAGCAGACTCAGCTCTGACA
Motif Score	2.951386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734084
mod ID: M6ASITE077045		Click to Show/Hide the Full List
mod site	chr6:131948828-131948829:-		[4]
Sequence	CATTCTCCAGCCATCAAGAGACTGAGTCAAGTTGTTCCTTA
Motif Score	3.319380952
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734085
mod ID: M6ASITE077046		Click to Show/Hide the Full List
mod site	chr6:131949044-131949045:-		[5]
Sequence	TGTTAAGACTTGACAGTGGAACTACATTAGTACACAGCACC
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; U2OS; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734086
mod ID: M6ASITE077047		Click to Show/Hide the Full List
mod site	chr6:131949057-131949058:-		[6]
Sequence	CTGGTTTGAAGAATGTTAAGACTTGACAGTGGAACTACATT
Motif Score	3.319380952
Cell/Tissue List	HepG2; HEK293T; HeLa; U2OS; hNPCs; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734087
mod ID: M6ASITE077048		Click to Show/Hide the Full List
mod site	chr6:131949080-131949081:-		[7]
Sequence	AAATAGTCTATCAACCCCAGACACTGGTTTGAAGAATGTTA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734088
mod ID: M6ASITE077049		Click to Show/Hide the Full List
mod site	chr6:131949102-131949103:-		[7]
Sequence	AAAACATTGTGCCATGTCAAACAAATAGTCTATCAACCCCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1B; H1A; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734089
mod ID: M6ASITE077050		Click to Show/Hide the Full List
mod site	chr6:131949119-131949120:-		[7]
Sequence	AGATTCCCACCCAATTCAAAACATTGTGCCATGTCAAACAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734090
mod ID: M6ASITE077051		Click to Show/Hide the Full List
mod site	chr6:131949219-131949220:-		[7]
Sequence	CTCATTAGACTGGAACTTGAACTGATTCACATCTCATTTTT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734091
mod ID: M6ASITE077052		Click to Show/Hide the Full List
mod site	chr6:131949225-131949226:-		[7]
Sequence	CATTAACTCATTAGACTGGAACTTGAACTGATTCACATCTC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734092
mod ID: M6ASITE077053		Click to Show/Hide the Full List
mod site	chr6:131949231-131949232:-		[7]
Sequence	GAGAGACATTAACTCATTAGACTGGAACTTGAACTGATTCA
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734093
mod ID: M6ASITE077054		Click to Show/Hide the Full List
mod site	chr6:131949246-131949247:-		[7]
Sequence	ATGAAGCCAGAGAGTGAGAGACATTAACTCATTAGACTGGA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; brain; kidney; liver; A549; hESC-HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734094
mod ID: M6ASITE077055		Click to Show/Hide the Full List
mod site	chr6:131949273-131949274:-		[7]
Sequence	CTACAGGAAGATGTACGGAGACATGGCATGAAGCCAGAGAG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734095
mod ID: M6ASITE077056		Click to Show/Hide the Full List
mod site	chr6:131949318-131949319:-		[7]
Sequence	CCATTACAACTGTCCCGGAGACAATGACATCTTTGAATCGC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734096
mod ID: M6ASITE077057		Click to Show/Hide the Full List
mod site	chr6:131949349-131949350:-		[7]
Sequence	AGAACATGATGTTCATCAAGACCTGTGCCTGCCATTACAAC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734097
mod ID: M6ASITE077058		Click to Show/Hide the Full List
mod site	chr6:131949366-131949367:-		[7]
Sequence	CGGCGAGGTCATGAAGAAGAACATGATGTTCATCAAGACCT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; Huh7; HEK293A-TOA; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734098
mod ID: M6ASITE077059		Click to Show/Hide the Full List
mod site	chr6:131949421-131949422:-		[8]
Sequence	GATGCTGCACCCCCCACAGAACCACCACCCTGCCGGTGGAG
Motif Score	2.930744048
Cell/Tissue List	HepG2; HeLa; U2OS; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734099
mod ID: M6ASITE077060		Click to Show/Hide the Full List
mod site	chr6:131949481-131949482:-		[9]
Sequence	CTGGCTGCACCAGCATGAAGACATACCGAGCTAAATTCTGT
Motif Score	2.897386905
Cell/Tissue List	U2OS; Huh7; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734100
mod ID: M6ASITE077061		Click to Show/Hide the Full List
mod site	chr6:131949955-131949956:-		[7]
Sequence	CGAAGCTGACCTGGAAGAGAACATTAAGGTACATGTTCTGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734101
mod ID: M6ASITE077062		Click to Show/Hide the Full List
mod site	chr6:131950067-131950068:-		[7]
Sequence	AGTGGAGCGCCTGTTCCAAGACCTGTGGGATGGGCATCTCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734102
mod ID: M6ASITE077063		Click to Show/Hide the Full List
mod site	chr6:131950094-131950095:-		[7]
Sequence	GAGCCAACTGCCTGGTCCAGACCACAGAGTGGAGCGCCTGT
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734103
mod ID: M6ASITE077064		Click to Show/Hide the Full List
mod site	chr6:131950129-131950130:-		[7]
Sequence	GGAAGACACGTTTGGCCCAGACCCAACTATGATTAGAGCCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734104
mod ID: M6ASITE077065		Click to Show/Hide the Full List
mod site	chr6:131950144-131950145:-		[7]
Sequence	CGCAGCTTACCGACTGGAAGACACGTTTGGCCCAGACCCAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734105
mod ID: M6ASITE077066		Click to Show/Hide the Full List
mod site	chr6:131950315-131950316:-		[7]
Sequence	GTGACGAGCCCAAGGACCAAACCGTGGTTGGGCCTGCCCTC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734106
mod ID: M6ASITE077067		Click to Show/Hide the Full List
mod site	chr6:131950320-131950321:-		[7]
Sequence	GGTGTGTGACGAGCCCAAGGACCAAACCGTGGTTGGGCCTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734107
mod ID: M6ASITE077068		Click to Show/Hide the Full List
mod site	chr6:131950975-131950976:-		[7]
Sequence	GCAGCCGGCCGTCGGCCAGAACTGCAGCGGGCCGTGCCGGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; A549; U2OS; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734108
mod ID: M6ASITE077069		Click to Show/Hide the Full List
mod site	chr6:131951342-131951343:-		[7]
Sequence	CTCTTCCCCGCTGAGAGGAGACAGCCAGTGCGACTCCACCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; A549; U2OS; H1A; H1B; hESCs; fibroblasts; H1299; HEK293A-TOA; MSC; TIME; iSLK; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000367976.4
External Link	RMBase: m6A_site_734111

Ref 1	Clinical pipeline report, company report or official report of GlycoMimetics.
Ref 2	Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2. Bioorg Med Chem. 2007 Jun 1;15(11):3635-48. doi: 10.1016/j.bmc.2007.03.055. Epub 2007 Mar 23.
Ref 3	ClinicalTrials.gov (NCT00003847) VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 4	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 5	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 6	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 7	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 8	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 9	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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