m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00685)
Target Name AC008440.5 (AC008)
Gene Name AC008
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
AC008 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary FTO-mediated N6-methyladenosine demethylation downregulated AC008440.5 (AC008) transcription, while lower FTO expression led to upregulation of AC008 transcription in OA.
Target Regulation Down regulation
Responsed Disease Osteoarthritis ICD-11: FA05
 Disease Info 
In-vitro Model Chondrocytes (Chondrocytes were isolated from human cartilage and cultured)
Osteoarthritis [ICD-11: FA05]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary FTO-mediated N6-methyladenosine demethylation downregulated AC008440.5 (AC008) transcription, while lower FTO expression led to upregulation of AC008 transcription in OA.
Responsed Disease Osteoarthritis [ICD-11: FA05]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Down regulation
In-vitro Model Chondrocytes (Chondrocytes were isolated from human cartilage and cultured)
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Fat mass and obesity-associated protein (FTO)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05619
 Crosstalk Info 
Epigenetic Regulator AC008440.5 (AC008)
Regulated Target hsa-miR-328-3p
Crosstalk relationship m6A → ncRNA
Disease Osteoarthritis
 Disease Info 
References
Ref 1 m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p?AQP1/ANKH axis. Exp Mol Med. 2021 Nov;53(11):1723-1734. doi: 10.1038/s12276-021-00696-7. Epub 2021 Nov 4.