m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00623)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
pri-miR-143
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL3 deficiency contributes to heart regeneration after MI via METTL3-pri-miR-143-(miR-143)-Yap/Ctnnd1 axis. | |||
| Target Regulation | Down regulation | |||
| Responsed Disease | Acute myocardial infarction | ICD-11: BA41 | ||
| In-vitro Model | neonatal ventricular myocytes (Mouse hearts were enzymatically digested to acquire the primary neonatal ventricular myocytes) | |||
| AC16 [Human hybrid cardiomyocyte] | Normal | Homo sapiens | CVCL_4U18 | |
Acute myocardial infarction [ICD-11: BA41]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL3 deficiency contributes to heart regeneration after MI via METTL3-pri-miR-143-(miR-143)-Yap/Ctnnd1 axis. | |||
| Responsed Disease | Acute myocardial infarction [ICD-11: BA41] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| In-vitro Model | neonatal ventricular myocytes (Mouse hearts were enzymatically digested to acquire the primary neonatal ventricular myocytes) | |||
| AC16 [Human hybrid cardiomyocyte] | Normal | Homo sapiens | CVCL_4U18 | |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 5 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00566 | ||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT00569 | ||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → m6Am | |
| Crosstalk ID: M6ACROT00572 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00575 | ||
| Epigenetic Regulator | H/ACA ribonucleoprotein complex subunit DKC1 (DKC1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → Pseudouridine | |
| Crosstalk ID: M6ACROT00578 | ||
| Epigenetic Regulator | RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) | |
| Regulated Target | H19 imprinted maternally expressed transcript (H19) | |
| Crosstalk relationship | m5C → m6A | |
m6A Regulator: Protein virilizer homolog (VIRMA)
| In total 5 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00567 | ||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT00570 | ||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → m6Am | |
| Crosstalk ID: M6ACROT00573 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00576 | ||
| Epigenetic Regulator | H/ACA ribonucleoprotein complex subunit DKC1 (DKC1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → Pseudouridine | |
| Crosstalk ID: M6ACROT00579 | ||
| Epigenetic Regulator | RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) | |
| Regulated Target | H19 imprinted maternally expressed transcript (H19) | |
| Crosstalk relationship | m5C → m6A | |
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
| In total 5 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00568 | ||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → A-to-I | |
| Crosstalk ID: M6ACROT00571 | ||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | |
| Regulated Target | Signal transducer and activator of transcription 3 (STAT3) | |
| Crosstalk relationship | m6A → m6Am | |
| Crosstalk ID: M6ACROT00574 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00577 | ||
| Epigenetic Regulator | H/ACA ribonucleoprotein complex subunit DKC1 (DKC1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → Pseudouridine | |
| Crosstalk ID: M6ACROT00580 | ||
| Epigenetic Regulator | RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) | |
| Regulated Target | H19 imprinted maternally expressed transcript (H19) | |
| Crosstalk relationship | m5C → m6A | |
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03311 | ||
| Epigenetic Regulator | Histone-lysine N-methyltransferase 2A (KMT2A) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Acute myocardial infarction | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05600 | ||
| Epigenetic Regulator | pri-miR-143 | |
| Regulated Target | YY1-associated protein 1 (YY1AP1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Acute myocardial infarction | |
| Crosstalk ID: M6ACROT06027 | ||
| Epigenetic Regulator | pri-miR-143 | |
| Regulated Target | Catenin delta-1 (CTNND1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Acute myocardial infarction | |