m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00578				[1], [2], [3], [4]
RNA modification H19 H19 NSUN2 Methylation : modification sites Indirect Enhancement m⁶A modification pri-miR-143 pri-miR-143 METTL3 Methylation : m⁶A sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	pri-miR-143				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2)			WRITER	View Details
Regulated Target	H19 imprinted maternally expressed transcript (H19)				View Details
Crosstalk Relationship	m5C → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with pri-miR-143, which was regulated by METTL3-mediated m6A modification.
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens		CVCL_0027
	NCI-H1975	Lung adenocarcinoma	Homo sapiens		CVCL_1511
	A-549	Lung adenocarcinoma	Homo sapiens		CVCL_0023
	AC16 [Human hybrid cardiomyocyte]	Normal	Homo sapiens		CVCL_4U18

References

Ref 1	Aberrant NSUN2-mediated m(5)C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma. Oncogene. 2020 Nov;39(45):6906-6919. doi: 10.1038/s41388-020-01475-w. Epub 2020 Sep 25.
Ref 2	N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1. Mol Cancer. 2019 Dec 10;18(1):181. doi: 10.1186/s12943-019-1108-x.
Ref 3	Loss of m(6)A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury. Pharmacol Res. 2021 Dec;174:105845. doi: 10.1016/j.phrs.2021.105845. Epub 2021 Aug 21.
Ref 4	6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy. Lab Invest. 2021 Jul;101(7):865-877. doi: 10.1038/s41374-021-00575-9. Epub 2021 Mar 23.