Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00147)

Target Name	H19 imprinted maternally expressed transcript (H19)
Synonyms	H19; H19, imprinted maternally expressed untranslated mRNA; H19, imprinted maternally expressed transcript (non-protein coding); D11S813E; ASM; ASM1; NCRNA00008; LINC00008; MIR675HG; non-protein coding RNA 8; long intergenic non-protein coding RNA 8; MIR675 host gene; adult skeletal muscle Click to Show/Hide
Gene Name	H19
Family	MicroRNA non-coding host genes; Long non-coding RNAs with non-systematic symbols
Gene ID	283120
HGNC ID	HGNC:4713
Ensembl Gene ID	ENSG00000130600
Chromosomal Location	11p15.5

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00147)

H19 imprinted maternally expressed transcript (H19)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000151		Click to Show/Hide the Full List
mod site	chr11:1995711-1995712:-
Sequence	CCCGCAGCACCCACCCCGCACCGGCGACTCCATCTTCATGG
Cell/Tissue List	DLD1
Seq Type List	acRIP-seq
Transcript ID List	ENST00000414790.6; ENST00000411861.5; ENST00000412788.5; ENST00000442037.5; ENST00000417089.6; ENST00000439725.5; ENST00000447298.2; ENST00000428066.6; ENST00000431095.6; ENST00000436715.5
External Link	RMBase: ac4C_site_261

5-methylcytidine (m5C)

In total 13 m6A sequence/site(s) in this target gene
mod ID: M5CSITE004819		Click to Show/Hide the Full List
mod site	chr11:1995231-1995232:-		[1]
Sequence	ATCTCGCTCTGTGCCCCTCCCCACCAGGGCTTCAGCAGGAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000412788.5; ENST00000439725.5; ENST00000442037.5; ENST00000411861.5; ENST00000414790.6; ENST00000417089.6
External Link	RMBase: m5C_site_6536
mod ID: M5CSITE004820		Click to Show/Hide the Full List
mod site	chr11:1995502-1995503:-		[1]
Sequence	CTCCACGACTCTGTTTCCCCCGTCCCTTCTGAATTTAATTT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000442037.5; ENST00000411861.5; ENST00000417089.6; ENST00000414790.6; ENST00000412788.5; ENST00000439725.5; ENST00000428066.6; ENST00000436715.5
External Link	RMBase: m5C_site_6537
mod ID: M5CSITE004821		Click to Show/Hide the Full List
mod site	chr11:1995503-1995504:-		[1]
Sequence	CCTCCACGACTCTGTTTCCCCCGTCCCTTCTGAATTTAATT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000442037.5; ENST00000436715.5; ENST00000414790.6; ENST00000439725.5; ENST00000428066.6; ENST00000411861.5; ENST00000412788.5; ENST00000417089.6
External Link	RMBase: m5C_site_6538
mod ID: M5CSITE004822		Click to Show/Hide the Full List
mod site	chr11:1995799-1995800:-		[1]
Sequence	TCCCACCCACGTGTCGCTATCTCTAGGTGAAGCTAGAGGAA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000417089.6; ENST00000414790.6; ENST00000411861.5; ENST00000442037.5; ENST00000436715.5; ENST00000431095.6; ENST00000412788.5; ENST00000447298.2; ENST00000439725.5; ENST00000428066.6
External Link	RMBase: m5C_site_6539
mod ID: M5CSITE004823		Click to Show/Hide the Full List
mod site	chr11:1995803-1995804:-		[1]
Sequence	CCCATCCCACCCACGTGTCGCTATCTCTAGGTGAAGCTAGA
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000439725.5; ENST00000428066.6; ENST00000447298.2; ENST00000436715.5; ENST00000412788.5; ENST00000414790.6; ENST00000431095.6; ENST00000417089.6; ENST00000411861.5; ENST00000442037.5
External Link	RMBase: m5C_site_6540
mod ID: M5CSITE004824		Click to Show/Hide the Full List
mod site	chr11:1996002-1996003:-		[1]
Sequence	GACCTCACTCCTTCCCCATCCACAGAAATGGTGCTACCCAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000442037.5; ENST00000436715.5; ENST00000417089.6; ENST00000431095.6; ENST00000414790.6; ENST00000439725.5; ENST00000412788.5; ENST00000428066.6; ENST00000411861.5; ENST00000447298.2
External Link	RMBase: m5C_site_6541
mod ID: M5CSITE004825		Click to Show/Hide the Full List
mod site	chr11:1996423-1996424:-		[1]
Sequence	CGACTCTCTCGTTCTCCCCACAGCCAGGTCTCCAGCTGGGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000447298.2; ENST00000436715.5; ENST00000411861.5; ENST00000439725.5; ENST00000417089.6; ENST00000428066.6; ENST00000412788.5; ENST00000414790.6
External Link	RMBase: m5C_site_6542
mod ID: M5CSITE004826		Click to Show/Hide the Full List
mod site	chr11:1996426-1996427:-		[1]
Sequence	ACACGACTCTCTCGTTCTCCCCACAGCCAGGTCTCCAGCTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000436715.5; ENST00000428066.6; ENST00000411861.5; ENST00000412788.5; ENST00000417089.6; ENST00000439725.5; ENST00000447298.2; ENST00000414790.6
External Link	RMBase: m5C_site_6543
mod ID: M5CSITE004827		Click to Show/Hide the Full List
mod site	chr11:1996427-1996428:-		[1]
Sequence	CACACGACTCTCTCGTTCTCCCCACAGCCAGGTCTCCAGCT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000412788.5; ENST00000428066.6; ENST00000436715.5; ENST00000414790.6; ENST00000411861.5; ENST00000439725.5; ENST00000447298.2; ENST00000417089.6
External Link	RMBase: m5C_site_6544
mod ID: M5CSITE004828		Click to Show/Hide the Full List
mod site	chr11:1996889-1996890:-		[1]
Sequence	AGGGGGGCCCCGGGACATTGCGCAGCAAGGAGGCTGCAGGG
Cell/Tissue List	liver; muscle; HeLa
Seq Type List	Bisulfite-seq; m5C-RIP-seq
Transcript ID List	ENST00000428066.6; ENST00000412788.5; ENST00000439725.5; ENST00000411861.5; ENST00000414790.6
External Link	RMBase: m5C_site_6545
mod ID: M5CSITE004829		Click to Show/Hide the Full List
mod site	chr11:1997386-1997387:-		[1]
Sequence	CCGGGCAGGTGAGTCCCTTCCCTCCCCAGGCCTCGCTTCCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000414790.6; ENST00000643292.1; ENST00000439725.5; ENST00000428066.6; ENST00000412788.5; ENST00000422826.2
External Link	RMBase: m5C_site_6546
mod ID: M5CSITE004830		Click to Show/Hide the Full List
mod site	chr11:1997387-1997388:-		[1]
Sequence	GCCGGGCAGGTGAGTCCCTTCCCTCCCCAGGCCTCGCTTCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000643292.1; ENST00000439725.5; ENST00000414790.6; ENST00000422826.2; ENST00000428066.6; ENST00000412788.5
External Link	RMBase: m5C_site_6547
mod ID: M5CSITE004831		Click to Show/Hide the Full List
mod site	chr11:1997391-1997392:-		[1]
Sequence	ATCTGCCGGGCAGGTGAGTCCCTTCCCTCCCCAGGCCTCGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000428066.6; ENST00000422826.2; ENST00000412788.5; ENST00000643292.1; ENST00000414790.6; ENST00000439725.5
External Link	RMBase: m5C_site_6548

N6-methyladenosine (m6A)

In total 25 m6A sequence/site(s) in this target gene
mod ID: M6ASITE002985		Click to Show/Hide the Full List
mod site	chr11:1995740-1995741:-		[2]
Sequence	ACATCAAAGACACCATCGGAACAGCAGCGCCCGCAGCACCC
Motif Score	2.951386905
Cell/Tissue List	HepG2; HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000439725.5; ENST00000428066.6; ENST00000442037.5; ENST00000411861.5; ENST00000414790.6; ENST00000436715.5; ENST00000412788.5; ENST00000431095.6; ENST00000417089.6; ENST00000447298.2
External Link	RMBase: m6A_site_126888
mod ID: M6ASITE002986		Click to Show/Hide the Full List
mod site	chr11:1995751-1995752:-		[2]
Sequence	TCATCAGCCCAACATCAAAGACACCATCGGAACAGCAGCGC
Motif Score	2.897386905
Cell/Tissue List	HepG2; HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000412788.5; ENST00000439725.5; ENST00000411861.5; ENST00000447298.2; ENST00000442037.5; ENST00000428066.6; ENST00000414790.6; ENST00000431095.6; ENST00000417089.6; ENST00000436715.5
External Link	RMBase: m6A_site_126889
mod ID: M6ASITE002987		Click to Show/Hide the Full List
mod site	chr11:1995774-1995775:-		[2]
Sequence	GGTGAAGCTAGAGGAACCAGACCTCATCAGCCCAACATCAA
Motif Score	2.876744048
Cell/Tissue List	HepG2; HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000417089.6; ENST00000412788.5; ENST00000436715.5; ENST00000447298.2; ENST00000428066.6; ENST00000414790.6; ENST00000431095.6; ENST00000411861.5; ENST00000442037.5; ENST00000439725.5
External Link	RMBase: m6A_site_126890
mod ID: M6ASITE002988		Click to Show/Hide the Full List
mod site	chr11:1995779-1995780:-		[2]
Sequence	CTCTAGGTGAAGCTAGAGGAACCAGACCTCATCAGCCCAAC
Motif Score	2.930744048
Cell/Tissue List	HepG2; HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000439725.5; ENST00000431095.6; ENST00000411861.5; ENST00000414790.6; ENST00000428066.6; ENST00000442037.5; ENST00000436715.5; ENST00000447298.2; ENST00000412788.5; ENST00000417089.6
External Link	RMBase: m6A_site_126891
mod ID: M6ASITE002989		Click to Show/Hide the Full List
mod site	chr11:1995949-1995950:-		[2]
Sequence	CCTTTGAATCCGGACACAAAACCCTCTAGCTTGGAAATGAA
Motif Score	2.185083333
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000411861.5; ENST00000439725.5; ENST00000428066.6; ENST00000417089.6; ENST00000414790.6; ENST00000447298.2; ENST00000442037.5; ENST00000436715.5; ENST00000431095.6; ENST00000412788.5
External Link	RMBase: m6A_site_126892
mod ID: M6ASITE002990		Click to Show/Hide the Full List
mod site	chr11:1995956-1995957:-		[2]
Sequence	GCCTGGGCCTTTGAATCCGGACACAAAACCCTCTAGCTTGG
Motif Score	3.643047619
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000442037.5; ENST00000412788.5; ENST00000417089.6; ENST00000447298.2; ENST00000414790.6; ENST00000411861.5; ENST00000436715.5; ENST00000439725.5; ENST00000428066.6; ENST00000431095.6
External Link	RMBase: m6A_site_126893
mod ID: M6ASITE002991		Click to Show/Hide the Full List
mod site	chr11:1996021-1996022:-		[2]
Sequence	CGCGAGAGGAGCTGAGTGGGACCTCACTCCTTCCCCATCCA
Motif Score	3.622404762
Cell/Tissue List	HepG2; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000439725.5; ENST00000442037.5; ENST00000436715.5; ENST00000428066.6; ENST00000417089.6; ENST00000447298.2; ENST00000412788.5; ENST00000411861.5; ENST00000431095.6; ENST00000414790.6
External Link	RMBase: m6A_site_126894
mod ID: M6ASITE002992		Click to Show/Hide the Full List
mod site	chr11:1996093-1996094:-		[2]
Sequence	CTGCCCTCTGGGCTCCCAGAACCCACAACATGAAAGGTGAG
Motif Score	2.930744048
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000439725.5; ENST00000447298.2; ENST00000442037.5; ENST00000431095.6; ENST00000417089.6; ENST00000414790.6; ENST00000428066.6; ENST00000412788.5; ENST00000411861.5; ENST00000436715.5
External Link	RMBase: m6A_site_126895
mod ID: M6ASITE002993		Click to Show/Hide the Full List
mod site	chr11:1996189-1996190:-		[2]
Sequence	CGACCTCTGTCTTCTACAGAACACCTTAGGCTGGTGGGGCT
Motif Score	2.951386905
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000447298.2; ENST00000439725.5; ENST00000414790.6; ENST00000412788.5; ENST00000411861.5; ENST00000431095.6; ENST00000442037.5; ENST00000428066.6; ENST00000436715.5; ENST00000417089.6
External Link	RMBase: m6A_site_126896
mod ID: M6ASITE002994		Click to Show/Hide the Full List
mod site	chr11:1996240-1996241:-		[2]
Sequence	CAGGACGCGGCCCTGCCCAGACCGCCCCGCCGGGCCACCAT
Motif Score	2.876744048
Cell/Tissue List	HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000411861.5; ENST00000428066.6; ENST00000417089.6; ENST00000447298.2; ENST00000431095.6; ENST00000414790.6; ENST00000439725.5; ENST00000436715.5; ENST00000412788.5
External Link	RMBase: m6A_site_126897
mod ID: M6ASITE002995		Click to Show/Hide the Full List
mod site	chr11:1996312-1996313:-		[3]
Sequence	GGTCCGGTGTGACGGCGAGGACAGAGGAGGCGCGTCCGGCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; kidney; liver; HepG2; endometrial
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000439725.5; ENST00000436715.5; ENST00000447298.2; ENST00000428066.6; ENST00000411861.5; ENST00000412788.5; ENST00000417089.6; ENST00000414790.6
External Link	RMBase: m6A_site_126898
mod ID: M6ASITE002996		Click to Show/Hide the Full List
mod site	chr11:1996341-1996342:-		[3]
Sequence	CGGTGGACGTGACAAGCAGGACATGACATGGTCCGGTGTGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000447298.2; ENST00000436715.5; ENST00000414790.6; ENST00000412788.5; ENST00000411861.5; ENST00000417089.6; ENST00000439725.5; ENST00000428066.6
External Link	RMBase: m6A_site_126899
mod ID: M6ASITE002997		Click to Show/Hide the Full List
mod site	chr11:1996350-1996351:-		[4]
Sequence	CGCCAGGTCCGGTGGACGTGACAAGCAGGACATGACATGGT
Motif Score	2.859755952
Cell/Tissue List	liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000412788.5; ENST00000414790.6; ENST00000411861.5; ENST00000439725.5; ENST00000417089.6; ENST00000428066.6; ENST00000436715.5; ENST00000447298.2
External Link	RMBase: m6A_site_126900
mod ID: M6ASITE002998		Click to Show/Hide the Full List
mod site	chr11:1997089-1997090:-		[3]
Sequence	GACATGGCAGGGGACACAGGACAGAGGGGTCCCCAGCTGCC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000411861.5; ENST00000422826.2; ENST00000439725.5; ENST00000412788.5; ENST00000414790.6; ENST00000643292.1; ENST00000428066.6
External Link	RMBase: m6A_site_126901
mod ID: M6ASITE002999		Click to Show/Hide the Full List
mod site	chr11:1997096-1997097:-		[3]
Sequence	AGACAGGGACATGGCAGGGGACACAGGACAGAGGGGTCCCC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000411861.5; ENST00000412788.5; ENST00000422826.2; ENST00000414790.6; ENST00000428066.6; ENST00000439725.5; ENST00000643292.1
External Link	RMBase: m6A_site_126902
mod ID: M6ASITE003000		Click to Show/Hide the Full List
mod site	chr11:1997108-1997109:-		[3]
Sequence	CAGGCCTGGGTCAGACAGGGACATGGCAGGGGACACAGGAC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000428066.6; ENST00000439725.5; ENST00000412788.5; ENST00000414790.6; ENST00000422826.2; ENST00000411861.5; ENST00000643292.1
External Link	RMBase: m6A_site_126903
mod ID: M6ASITE003001		Click to Show/Hide the Full List
mod site	chr11:1997114-1997115:-		[3]
Sequence	GTACCCCAGGCCTGGGTCAGACAGGGACATGGCAGGGGACA
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000428066.6; ENST00000411861.5; ENST00000439725.5; ENST00000414790.6; ENST00000643292.1; ENST00000412788.5; ENST00000422826.2
External Link	RMBase: m6A_site_126904
mod ID: M6ASITE003002		Click to Show/Hide the Full List
mod site	chr11:1997237-1997238:-		[3]
Sequence	TCTTCTCGGGGGGAGCCGAGACTGCGCAAGGCTGGGGGGTT
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000428066.6; ENST00000422826.2; ENST00000643292.1; ENST00000439725.5; ENST00000412788.5; ENST00000414790.6
External Link	RMBase: m6A_site_126905
mod ID: M6ASITE003003		Click to Show/Hide the Full List
mod site	chr11:1997311-1997312:-		[3]
Sequence	GGGCTGGCGGGGAGAAGCAGACACCCTCCCAGCAGAGGGGC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000414790.6; ENST00000422826.2; ENST00000643292.1; ENST00000428066.6; ENST00000412788.5; ENST00000439725.5
External Link	RMBase: m6A_site_126906
mod ID: M6ASITE003004		Click to Show/Hide the Full List
mod site	chr11:1997416-1997417:-		[3]
Sequence	GCAGCAGCGGGCAGGTGAGGACCCCATCTGCCGGGCAGGTG
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000422826.2; ENST00000414790.6; ENST00000412788.5; ENST00000428066.6; ENST00000643292.1; ENST00000439725.5
External Link	RMBase: m6A_site_126907
mod ID: M6ASITE003005		Click to Show/Hide the Full List
mod site	chr11:1997604-1997605:-		[3]
Sequence	GGCGCCCAGGCATCGTGCAGACAGGGCGACATCAGCTGGGG
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000428066.6; ENST00000412788.5; ENST00000422826.2; ENST00000414790.6; ENST00000643292.1
External Link	RMBase: m6A_site_126908
mod ID: M6ASITE003006		Click to Show/Hide the Full List
mod site	chr11:1997715-1997716:-		[3]
Sequence	GGAGCCAAGGAGCACCTTGGACATCTGGAGTCTGGCAGGAG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000412788.5; ENST00000414790.6; ENST00000428066.6; ENST00000422826.2; ENST00000643292.1
External Link	RMBase: m6A_site_126909
mod ID: M6ASITE003007		Click to Show/Hide the Full List
mod site	chr11:1997782-1997783:-		[3]
Sequence	GGAAACTGGGGAAGTGGGGAACCGAGGGGCAACCAGGGGAA
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000414790.6; ENST00000428066.6; ENST00000412788.5; ENST00000422826.2; ENST00000643292.1
External Link	RMBase: m6A_site_126910
mod ID: M6ASITE003008		Click to Show/Hide the Full List
mod site	chr11:1997798-1997799:-		[3]
Sequence	GGTGGGGGGTAACGGGGGAAACTGGGGAAGTGGGGAACCGA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000643292.1; ENST00000414790.6; ENST00000422826.2; ENST00000412788.5; ENST00000428066.6
External Link	RMBase: m6A_site_126911
mod ID: M6ASITE003009		Click to Show/Hide the Full List
mod site	chr11:1997851-1997852:-		[3]
Sequence	TAGAAAAAGCCCGGGCTAGGACCGAGGAGCAGGGTGAGGGA
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000422826.2; ENST00000643292.1; ENST00000414790.6; ENST00000428066.6
External Link	RMBase: m6A_site_126912

Ref 1	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 2	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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