m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00495)
Target Name hsa_circ_0008542 (Circ_PHF12)
Gene Name Circ_PHF12
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_PHF12 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 acts on the m6A functional site of 1956 bp in hsa_circ_0008542. RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with miRNA-185-5p to correct the bone resorption process.
Target Regulation Up regulation
Responsed Disease Diseases of the musculoskeletal system ICD-11: FC0Z
 Disease Info 
Cell Process RNA stability
In-vitro Model RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
MC3T3-E1 Normal Mus musculus CVCL_0409
In-vivo Model Circ_0008542, where rats were injected with exosomes containing circ_0008542 into the tail vein for 8 weeks.
RNA demethylase ALKBH5 (ALKBH5) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary METTL3 acts on the m6A functional site of 1956 bp in hsa_circ_0008542. RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with miRNA-185-5p to correct the bone resorption process.
Target Regulation Down regulation
Responsed Disease Diseases of the musculoskeletal system ICD-11: FC0Z
 Disease Info 
Cell Process RNA stability
In-vitro Model RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
MC3T3-E1 Normal Mus musculus CVCL_0409
In-vivo Model Circ_0008542, where rats were injected with exosomes containing circ_0008542 into the tail vein for 8 weeks.
Diseases of the musculoskeletal system [ICD-11: FC0Z]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 acts on the m6A functional site of 1956 bp in hsa_circ_0008542. RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with miRNA-185-5p to correct the bone resorption process.
Responsed Disease Diseases of the musculoskeletal system [ICD-11: FC0Z]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process RNA stability
In-vitro Model RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
MC3T3-E1 Normal Mus musculus CVCL_0409
In-vivo Model Circ_0008542, where rats were injected with exosomes containing circ_0008542 into the tail vein for 8 weeks.
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary METTL3 acts on the m6A functional site of 1956 bp in hsa_circ_0008542. RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with miRNA-185-5p to correct the bone resorption process.
Responsed Disease Diseases of the musculoskeletal system [ICD-11: FC0Z]
Target Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
Target Regulation Down regulation
Cell Process RNA stability
In-vitro Model RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
MC3T3-E1 Normal Mus musculus CVCL_0409
In-vivo Model Circ_0008542, where rats were injected with exosomes containing circ_0008542 into the tail vein for 8 weeks.
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05569
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0008542 (Circ_PHF12)
Regulated Target hsa-miR-185-5p
Crosstalk relationship m6A → ncRNA
Disease Diseases of the musculoskeletal system
 Disease Info 
m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05570
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0008542 (Circ_PHF12)
Regulated Target hsa-miR-185-5p
Crosstalk relationship m6A → ncRNA
Disease Diseases of the musculoskeletal system
 Disease Info 
References
Ref 1 Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation. Cell Death Dis. 2021 Jun 18;12(7):628. doi: 10.1038/s41419-021-03915-1.