m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05570
 [1]
m6A modification Circ_PHF12 Circ_PHF12 ALKBH5 Demethylation : m6A sites Direct Inhibition Non-coding RNA circ_0008542 miR-185-5p  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target hsa_circ_0008542 (Circ_PHF12)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa_circ_0008542 (Circ_PHF12) circRNA View Details
Regulated Target hsa-miR-185-5p View Details
Crosstalk Relationship m6A  →  ncRNA Inhibition
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary METTL3 acts on the m6A functional site of 1956 bp in hsa_circ_0008542. RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with hsa-miR-185-5p to correct the bone resorption process.
Responsed Disease Diseases of the musculoskeletal system ICD-11: FC0Z
 Disease Info 
In-vitro Model
 RAW 264.7 Mouse leukemia Mus musculus CVCL_0493
MC3T3-E1 Normal Mus musculus CVCL_0409
In-vivo Model circ_0008542, where rats were injected with exosomes containing circ_0008542 into the tail vein for 8 weeks.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
FC0Z: Diseases of the musculoskeletal system 20 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name NERIDRONIC ACID Approved [2]
Synonyms
79778-41-9; Nerixia; Neridronic acid [INN]; (6-Amino-1-hydroxyhexane-1,1-diyl)diphosphonic acid; UNII-8U27U3RIN4; Acide neridronique [INN-French]; Acido neridronico [INN-Spanish]; Acidum neridronicum [INN-Latin]; CHEMBL55214; 8U27U3RIN4; NERIDRONATE SODIUM HYDRATE; (6-Amino-1-hydroxyhexylidene)diphosphonic acid; 6-Amino-1-hydroxyhexane-1,1-diphosphonate; 6-amino-1-hydroxyhexane-1,1-diyldiphosphonic acid; W-203821; Phosphonic acid, (6-amino-1-hydroxyhexylidene)bis-
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CID: 71237
TTD: D0V8PA
DrugBank: DB11620
 Compound Name Rh-bmp-2/acs Approved [2]
Synonyms
Infuse (TN)
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TTD: D0I6FS
 Compound Name Technetium TC 99M medronate Approved [2]
Synonyms
TC[99M] medronate
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CID: 131704315
TTD: D0B4KH
DrugBank: DB09138
 Compound Name HMGB-1 protein and its fragments Phase 3 [3]
Synonyms
CTR-1; CTR-2; CTR-3; CTR-4; HMGB-1 protein and its fragments (wound healing/cartilage repair/bone matrixregeneration/ligaments and tendon repair); HMGB-1 protein and its fragments (wound healing/cartilage repair/bone matrix regeneration/ligaments and tendon repair), Bio3
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TTD: D0R8QX
 Compound Name Bafetinib Phase 2 [4]
Synonyms
859212-16-1; INNO-406; NS-187; UNII-NVW4Z03I9B; CNS-9; NVW4Z03I9B; INNO406; CHEMBL206834; (S)-N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)benzamide; 4-[[(3S)-3-DIMETHYLAMINOPYRROLIDIN-1-YL]METHYL]-N-[4-METHYL-3-[(4-PYRIMIDIN-5-YLPYRIMIDIN-2-YL)AMINO]PHENYL]-3-(TRIFLUOROMETHYL)BENZAMIDE; INNO 406; NS 187; N-[3-(4,5'-Bipyrimidin-2-Ylamino)-4-Methylphenyl]-4-{[(3s)-3-(Dimethylamino)pyrrolidin-1-Yl]methyl}-3-(Trifluoromethyl)benzamide
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CID: 11387605
TTD: D0G0VV
DrugBank: DB11851
 Compound Name KUR-111 Phase 2 [5]
Synonyms
I-0401; I-040302; TGplPTH1-34; Fibrin-PTH (bone cysts), Kuros; Human parathyroid hormone (PTH) + TISSEEL fibrin sealant + hydroxyapatite/tri-calcium phosphate granules (bone fracture), Kuros/Baxter
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TTD: D0F4SN
 Compound Name MDAB-16 Phase 2 [6]
Synonyms
Humanized antibody (cancer), Med discovery
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TTD: D02EFJ
 Compound Name KUR-112 Phase 1 [7]
External Link
TTD: D09TGD
 Compound Name GW-2592X Investigative [8]
Synonyms
Azepanone inhibitors, GlaxoSmithKline; Cathepsin K inhibitors (bone disorder); Cathepsin K inhibitors, SmithKline Beecham; GW-2637X; GW-2934X; GW-9696X; SB-237632; SB-244875; SB-267320; SB-271194; SB-327537; SB-331750; SB-357114; SB-432238; SB-553484; Cathepsin K inhibitors (bone disorder), GlaxoSmithKline
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TTD: D0FJ3P
 Compound Name HR-004-1 Investigative [9]
Synonyms
HR-004; Mesenchymal stem cell therapy (bone regeneration), Histocell/Laboratorios SALVAT
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TTD: D0VP7D
 Compound Name WX-04554 Investigative [9]
Synonyms
WX-07-0100117; Wnt pathway activators (bone healing and repair), Wintherix
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TTD: D0T6AY
 Compound Name BRX-3 Investigative [9]
Synonyms
RUNX2 modulator (bone disease), Biorunx; Runt-related transcription factor 2 modulator (bone disease), Biorunx
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TTD: D0T1OR
 Compound Name TG-N Investigative [9]
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TTD: D0R9XX
 Compound Name OLPADRONIC ACID SODIUM SALT Investigative [10]
Synonyms
Dimethyl-APD; IG-8801; 3-(Dimethylamino)-1-hydroxypropylidene-1,1-diphosphonic acid monosodium salt
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CID: 23663414
TTD: D0OJ5M
 Compound Name HG-1429 Investigative [9]
Synonyms
HMAAD57 modulator (immune/bone diseases), Human Genome Sciences; TREM2 modulator (immune/bone diseases), Human Genome Sciences; Triggering receptor expressed on myeloid cells 2 modulator (immune/bone diseases), Human Genome Sciences; Trem2a/2b/2c modulator (immune/bone diseases), Human Genome Sciences
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TTD: D0G3UG
 Compound Name TGX-003 Investigative [9]
Synonyms
MeniscoCelect; Allogeneic cell therapy (traumatic meniscus lesions), Tigenix
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TTD: D0A3OA
 Compound Name PG-1014491 Investigative [11]
Synonyms
PG-1014493; Farnesyl pyrophosphate synthase (FPS) bisphosphonate inhibitors (bone disorders), Procter & Gamble
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TTD: D06QJG
 Compound Name ALSE-100 Investigative [9]
Synonyms
RhoA inhibitors (cardiomyopathy/cancer and CNS/ocular/bone disorders); RhoA inhibitors (cardiomyopathy/cancer and CNS/ocular/bone disorders), Alseres
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TTD: D05NJL
 Compound Name AB-0440a Investigative [9]
Synonyms
TSP-50 targeting monoclonal antibodies (bone loss/osteoporosis); Anti-testes specific protease 50 antibody (boneloss/osteoporosis), Alethia; TSP-50 targeting monoclonal antibodies (bone loss/osteoporosis), Alethia; AB-0440-targeting monoclonal antibodies (bone loss/osteoporosis), Alethia
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TTD: D02DWN
 Compound Name TG-D Investigative [9]
External Link
TTD: D01XMP
References
Ref 1 Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation. Cell Death Dis. 2021 Jun 18;12(7):628. doi: 10.1038/s41419-021-03915-1.
Ref 2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 3 ClinicalTrials.gov (NCT02137512) Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use. U.S. National Institutes of Health.
Ref 4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7906).
Ref 5 ClinicalTrials.gov (NCT00459641) Safety and Tolerability of I-040302 in Children and Young Adults With Solitary Bone Cysts. U.S. National Institutes of Health.
Ref 6 Med Discovery SA report. David Deperthes, PhD. 2002.
Ref 7 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029426)
Ref 8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350).
Ref 9 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Ref 10 Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4.
Ref 11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 643).