m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00371)
Target Name DNA polymerase kappa (Pol Kappa/POLK)
Synonyms
DINB protein; DINP; DINB1
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Gene Name POLK
Chromosomal Location 5q13.3
Family DNA polymerase type-Y family
Function
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
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Gene ID 51426
Uniprot ID
POLK_HUMAN
HGNC ID
HGNC:9183
Ensembl Gene ID
ENSG00000122008
KEGG ID
hsa:51426
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
POLK can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line mouse embryonic stem cells Mus musculus
Treatment: METTL3-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: 8.09E-01
p-value: 1.19E-26
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between POLK and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 1.90E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Methylation at the 6 position of adenosine (m6A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation. This modification occurs on numerous poly(A)+ transcripts and is regulated by the methyltransferase METTL3 and the demethylase FTO. DNA DNA polymerase kappa (Pol Kappa/POLK), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the catalytic activity of METTL3 for immediate localization to ultraviolet-induced DNA damage sites.
Target Regulation Up regulation
Responsed Disease Exposure to radiation ICD-11: PH73
 Disease Info 
Cell Process DNA repair
Nucleotide excision repair (hsa03420)
In-vitro Model A-375 Amelanotic melanoma Homo sapiens CVCL_0132
U2OS Osteosarcoma Homo sapiens CVCL_0042
HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MEF (Mouse embryonic fibroblasts)
U2OS Osteosarcoma Homo sapiens CVCL_0042
Fat mass and obesity-associated protein (FTO) [ERASER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Methylation at the 6 position of adenosine (m6A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation. This modification occurs on numerous poly(A)+ transcripts and is regulated by the methyltransferase METTL3 and the demethylase FTO. DNA DNA polymerase kappa (Pol Kappa/POLK), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the catalytic activity of METTL3 for immediate localization to ultraviolet-induced DNA damage sites.
Target Regulation Up regulation
Responsed Disease Exposure to radiation ICD-11: PH73
 Disease Info 
Cell Process DNA repair
Nucleotide excision repair (hsa03420)
In-vitro Model A-375 Amelanotic melanoma Homo sapiens CVCL_0132
U2OS Osteosarcoma Homo sapiens CVCL_0042
HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MEF (Mouse embryonic fibroblasts)
U2OS Osteosarcoma Homo sapiens CVCL_0042
Exposure to radiation [ICD-11: PH73]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Methylation at the 6 position of adenosine (m6A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation. This modification occurs on numerous poly(A)+ transcripts and is regulated by the methyltransferase METTL3 and the demethylase FTO. DNA DNA polymerase kappa (Pol Kappa/POLK), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the catalytic activity of METTL3 for immediate localization to ultraviolet-induced DNA damage sites.
Responsed Disease Exposure to radiation [ICD-11: PH73]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
Cell Process DNA repair
Nucleotide excision repair (hsa03420)
In-vitro Model A-375 Amelanotic melanoma Homo sapiens CVCL_0132
U2OS Osteosarcoma Homo sapiens CVCL_0042
HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MEF (Mouse embryonic fibroblasts)
U2OS Osteosarcoma Homo sapiens CVCL_0042
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary Methylation at the 6 position of adenosine (m6A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation. This modification occurs on numerous poly(A)+ transcripts and is regulated by the methyltransferase METTL3 and the demethylase FTO. DNA DNA polymerase kappa (Pol Kappa/POLK), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the catalytic activity of METTL3 for immediate localization to ultraviolet-induced DNA damage sites.
Responsed Disease Exposure to radiation [ICD-11: PH73]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process DNA repair
Nucleotide excision repair (hsa03420)
In-vitro Model A-375 Amelanotic melanoma Homo sapiens CVCL_0132
U2OS Osteosarcoma Homo sapiens CVCL_0042
HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MEF (Mouse embryonic fibroblasts)
U2OS Osteosarcoma Homo sapiens CVCL_0042
References
Ref 1 RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response. Nature. 2017 Mar 23;543(7646):573-576. doi: 10.1038/nature21671. Epub 2017 Mar 15.