m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0127)
Name
Exposure to radiation
ICD
ICD-11: PH73
Full List of Target Gene(s) of This m6A-centered Disease Response
DNA polymerase kappa (Pol Kappa/POLK)
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Methylation at the 6 position of adenosine (m6A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation. This modification occurs on numerous poly(A)+ transcripts and is regulated by the methyltransferase METTL3 and the demethylase FTO. DNA DNA polymerase kappa (Pol Kappa/POLK), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the catalytic activity of METTL3 for immediate localization to ultraviolet-induced DNA damage sites.
Responsed Disease Exposure to radiation [ICD-11: PH73]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Cell Process DNA repair
Nucleotide excision repair (hsa03420)
In-vitro Model A-375 Amelanotic melanoma Homo sapiens CVCL_0132
U2OS Osteosarcoma Homo sapiens CVCL_0042
HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MEF (Mouse embryonic fibroblasts)
U2OS Osteosarcoma Homo sapiens CVCL_0042
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Methylation at the 6 position of adenosine (m6A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation. This modification occurs on numerous poly(A)+ transcripts and is regulated by the methyltransferase METTL3 and the demethylase FTO. DNA DNA polymerase kappa (Pol Kappa/POLK), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the catalytic activity of METTL3 for immediate localization to ultraviolet-induced DNA damage sites.
Responsed Disease Exposure to radiation [ICD-11: PH73]
Target Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
Target Regulation Up regulation
Cell Process DNA repair
Nucleotide excision repair (hsa03420)
In-vitro Model A-375 Amelanotic melanoma Homo sapiens CVCL_0132
U2OS Osteosarcoma Homo sapiens CVCL_0042
HEK293T Normal Homo sapiens CVCL_0063
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
MEF (Mouse embryonic fibroblasts)
U2OS Osteosarcoma Homo sapiens CVCL_0042
References
Ref 1 RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response. Nature. 2017 Mar 23;543(7646):573-576. doi: 10.1038/nature21671. Epub 2017 Mar 15.