m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00312)

Target Name	Pyruvate kinase PKM (PKM2/PKM)
Synonyms	Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58; OIP3; PK2; PK3; PKM2 Click to Show/Hide
Gene Name	PKM
Chromosomal Location	15q23
Family	pyruvate kinase family
Function	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. In addition to its role in glycolysis, also regulates transcription. Stimulates POU5F1-mediated transcriptional activation. Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). Also acts as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a general role in caspase independent cell death of tumor cells. Click to Show/Hide
Gene ID	5315
Uniprot ID	KPYM_HUMAN
HGNC ID	HGNC:9021
KEGG ID	hsa:5315

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

PKM can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Browse Drug

Fat mass and obesity-associated protein (FTO) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by FTO*
Cell Line	NB4 cell line	Homo sapiens
Treatment: shFTO NB4 cells Control: shNS NB4 cells		GSE103494
Regulation		logFC: 1.52E+00 p-value: 5.79E-04
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	The overexpression of demethylase FTO in the HCC tissue and cells. FTO could regulate the demethylation of Pyruvate kinase PKM (PKM2/PKM) in the hepatocellular carcinoma.
Target Regulation	Down regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Pathway Response	Central carbon metabolism in cancer			hsa05230
Cell Process	Glucose metabolism
In-vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens	CVCL_0326
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	L-02	Endocervical adenocarcinoma	Homo sapiens	CVCL_6926
	SMMC-7721	Endocervical adenocarcinoma	Homo sapiens	CVCL_0534
In-vivo Model	The transfected cells (2×10⁶) were directly subcutaneously injected in to flank of mice. The width and length were measured every six days. After three weeks, the mice were killed and the necropsies were weighted.

YTH domain-containing family protein 1 (YTHDF1) [READER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF1*
Cell Line	AGS cell line	Homo sapiens
Treatment: shYTHDF1 AGS Control: shControl AGS		GSE159425
Regulation		logFC: 6.97E-01 p-value: 4.17E-05
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	Tumor hypoxia can transcriptionally induce HIF1alpha and post-transcriptionally inhibit the expression of miR-16-5p to promote YTHDF1 expression, which could sequentially enhance tumor glycolysis by upregulating Pyruvate kinase PKM (PKM2/PKM) and eventually increase the tumorigenesis and metastasis potential of breast cancer cells.
Target Regulation	Up regulation
Responsed Disease	Breast cancer		ICD-11: 2C60	Disease Info
Pathway Response	HIF-1 signaling pathway			hsa04066
Cell Process	Glycolysis
In-vitro Model	T-47D	Invasive breast carcinoma	Homo sapiens	CVCL_0553
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens	CVCL_0062
	MCF-7	Invasive breast carcinoma	Homo sapiens	CVCL_0031
	MCF-10A	Normal	Homo sapiens	CVCL_0598
	BT-474	Invasive breast carcinoma	Homo sapiens	CVCL_0179
In-vivo Model	Each mouse was injected subcutaneously with 5 × 10⁶ units of tumor cells to construct the tumor model.

Zinc finger CCCH domain-containing protein 13 (ZC3H13) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ZC3H13*
Cell Line	Human umbilical vein endothelial cells	Homo sapiens
Treatment: siKIAA0853 HUVECs Control: siControl HUVECs		GSE167067
Regulation		logFC: -9.34E-01 p-value: 1.41E-02
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[3]
Response Summary	ZC3H13 overexpression sensitized to cisplatin and weakened metabolism reprogramming of HCC cells, ZC3H13-induced m6A modified patterns substantially abolished Pyruvate kinase PKM (PKM2/PKM) mRNA stability.
Target Regulation	Down regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Responsed Drug	Cisplatin		Approved	Drug Info
Pathway Response	Central carbon metabolism in cancer			hsa05230
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	SMMC-7721	Endocervical adenocarcinoma	Homo sapiens	CVCL_0534
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens	CVCL_0326

Liver cancer [ICD-11: 2C12]

Disease Info

In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	The overexpression of demethylase FTO in the HCC tissue and cells. FTO could regulate the demethylation of Pyruvate kinase PKM (PKM2/PKM) in the hepatocellular carcinoma.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	Fat mass and obesity-associated protein (FTO)		ERASER	Regulator Info
Target Regulation	Down regulation
Pathway Response	Central carbon metabolism in cancer			hsa05230
Cell Process	Glucose metabolism
In-vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens	CVCL_0326
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	L-02	Endocervical adenocarcinoma	Homo sapiens	CVCL_6926
	SMMC-7721	Endocervical adenocarcinoma	Homo sapiens	CVCL_0534
In-vivo Model	The transfected cells (2×10⁶) were directly subcutaneously injected in to flank of mice. The width and length were measured every six days. After three weeks, the mice were killed and the necropsies were weighted.
Experiment 2 Reporting the m6A-centered Disease Response				[3]
Response Summary	ZC3H13 overexpression sensitized to cisplatin and weakened metabolism reprogramming of HCC cells, ZC3H13-induced m6A modified patterns substantially abolished Pyruvate kinase PKM (PKM2/PKM) mRNA stability.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	Zinc finger CCCH domain-containing protein 13 (ZC3H13)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Drug	Cisplatin		Approved	Drug Info
Pathway Response	Central carbon metabolism in cancer			hsa05230
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	SMMC-7721	Endocervical adenocarcinoma	Homo sapiens	CVCL_0534
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens	CVCL_0326

Breast cancer [ICD-11: 2C60]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[2]
Response Summary	Tumor hypoxia can transcriptionally induce HIF1alpha and post-transcriptionally inhibit the expression of miR-16-5p to promote YTHDF1 expression, which could sequentially enhance tumor glycolysis by upregulating Pyruvate kinase PKM (PKM2/PKM) and eventually increase the tumorigenesis and metastasis potential of breast cancer cells.
Responsed Disease	Breast cancer [ICD-11: 2C60]
Target Regulator	YTH domain-containing family protein 1 (YTHDF1)		READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	HIF-1 signaling pathway			hsa04066
Cell Process	Glycolysis
In-vitro Model	T-47D	Invasive breast carcinoma	Homo sapiens	CVCL_0553
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens	CVCL_0062
	MCF-7	Invasive breast carcinoma	Homo sapiens	CVCL_0031
	MCF-10A	Normal	Homo sapiens	CVCL_0598
	BT-474	Invasive breast carcinoma	Homo sapiens	CVCL_0179
In-vivo Model	Each mouse was injected subcutaneously with 5 × 10⁶ units of tumor cells to construct the tumor model.

Cisplatin [Approved]

Drug Info

In total 1 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[3]
Response Summary	ZC3H13 overexpression sensitized to cisplatin and weakened metabolism reprogramming of HCC cells, ZC3H13-induced m6A modified patterns substantially abolished Pyruvate kinase PKM (PKM2/PKM) mRNA stability.
Target Regulator	Zinc finger CCCH domain-containing protein 13 (ZC3H13)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Pathway Response	Central carbon metabolism in cancer			hsa05230
Pathway Response	Glycolysis / Gluconeogenesis			hsa00010
Cell Process	Glycolysis
In-vitro Model	SMMC-7721	Endocervical adenocarcinoma	Homo sapiens	CVCL_0534
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens	CVCL_0326

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

Histone modification

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03418		Crosstalk Info
Regulated Target	Histone H3 lysine 4 trimethylation (H3K4me3)
Crosstalk relationship	Histone modification → m6A
Disease	Liver cancer	Disease Info
Crosstalk ID: M6ACROT03429		Crosstalk Info
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Liver cancer	Disease Info

Non-coding RNA

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05046		Crosstalk Info
Epigenetic Regulator	MicroRNA 145 (MIR145)
Regulated Target	YTH domain-containing family protein 2 (YTHDF2)
Crosstalk relationship	ncRNA → m6A
Disease	Liver cancer	Disease Info
Crosstalk ID: M6ACROT05316		Crosstalk Info
Epigenetic Regulator	FTO intronic transcript 1 (FTO-IT1)
Regulated Target	FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship	ncRNA → m6A
Disease	Liver cancer	Disease Info

m6A Regulator: Fat mass and obesity-associated protein (FTO)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05314		Crosstalk Info
Epigenetic Regulator	FTO intronic transcript 1 (FTO-IT1)
Regulated Target	FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship	ncRNA → m6A
Disease	Liver cancer	Disease Info

m6A Regulator: YTH domain-containing family protein 1 (YTHDF1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05322		Crosstalk Info
Epigenetic Regulator	hsa-miR-16-5p
Regulated Target	YTH domain-containing family protein 1 (YTHDF1)
Crosstalk relationship	ncRNA → m6A
Disease	Breast cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00312)

Pyruvate kinase PKM (PKM2/PKM)

Adenosine-to-Inosine editing (A-to-I)

In total 6 m6A sequence/site(s) in this target gene
mod ID: A2ISITE007040		Click to Show/Hide the Full List
mod site	chr15:72202815-72202816:-		[6]
Sequence	ATGTCACAGGCACTTGGTGAAGGACTGGTTTCTGTGGAGTC
Transcript ID List	ENST00000563986.1; ENST00000565184.5; ENST00000319622.10; ENST00000568459.5; ENST00000564440.5; ENST00000568883.5; ENST00000389093.7; ENST00000449901.6; ENST00000569857.5; ENST00000567118.5; ENST00000335181.10; ENST00000565154.5; ENST00000570166.1; ENST00000561609.5
External Link	RMBase: RNA-editing_site_44978
mod ID: A2ISITE007041		Click to Show/Hide the Full List
mod site	chr15:72203341-72203342:-		[6]
Sequence	AGTTGGACTTTCATCACCCTACCTCTGCATCTGCCTGAAGG
Transcript ID List	ENST00000569857.5; ENST00000570166.1; ENST00000567118.5; ENST00000565154.5; ENST00000561609.5; ENST00000335181.10; ENST00000568883.5; ENST00000449901.6; ENST00000563986.1; ENST00000568459.5; ENST00000319622.10; ENST00000565184.5; ENST00000564440.5; ENST00000389093.7
External Link	RMBase: RNA-editing_site_44979
mod ID: A2ISITE007042		Click to Show/Hide the Full List
mod site	chr15:72213143-72213144:-		[6]
Sequence	TCCATGACCAAGTAGATTTTATTCTAGGAGAACAAAATTCT
Transcript ID List	ENST00000562997.5; ENST00000565184.5; ENST00000568883.5; ENST00000567118.5; ENST00000562784.1; ENST00000564276.1; ENST00000335181.10; ENST00000565154.5; ENST00000319622.10; ENST00000567087.5; ENST00000569857.5; ENST00000561609.5; ENST00000389093.7; ENST00000449901.6; ENST00000568459.5; ENST00000564178.5; rmsk_4378892
External Link	RMBase: RNA-editing_site_44980
mod ID: A2ISITE007043		Click to Show/Hide the Full List
mod site	chr15:72224677-72224678:-		[7]
Sequence	TAGTGATGGTGTTTCACCATATTAGCCAGGCTGGTCTCGAA
Transcript ID List	ENST00000567118.5; ENST00000565184.5; ENST00000449901.6; ENST00000564276.1; ENST00000567087.5; ENST00000335181.10; ENST00000569050.1; ENST00000568459.5; ENST00000561609.5; ENST00000565154.5; ENST00000566809.1; ENST00000568883.5; ENST00000389093.7; ENST00000569857.5; ENST00000319622.10
External Link	RMBase: RNA-editing_site_44981
mod ID: A2ISITE007044		Click to Show/Hide the Full List
mod site	chr15:72224679-72224680:-		[7]
Sequence	AGTAGTGATGGTGTTTCACCATATTAGCCAGGCTGGTCTCG
Transcript ID List	ENST00000565184.5; ENST00000389093.7; ENST00000568459.5; ENST00000568883.5; ENST00000449901.6; ENST00000319622.10; ENST00000567118.5; ENST00000565154.5; ENST00000569857.5; ENST00000567087.5; ENST00000566809.1; ENST00000335181.10; ENST00000561609.5; ENST00000564276.1; ENST00000569050.1
External Link	RMBase: RNA-editing_site_44982
mod ID: A2ISITE007045		Click to Show/Hide the Full List
mod site	chr15:72224796-72224797:-		[6]
Sequence	CAGTGGTGCGATCTCCGTTCACTGCAGCCTCCACTTCCTGG
Transcript ID List	ENST00000561609.5; ENST00000389093.7; ENST00000564276.1; ENST00000335181.10; ENST00000569050.1; ENST00000319622.10; ENST00000449901.6; ENST00000568459.5; ENST00000566809.1; ENST00000568883.5; ENST00000569857.5; ENST00000567118.5; ENST00000567087.5; ENST00000565184.5; ENST00000565154.5
External Link	RMBase: RNA-editing_site_44983

5-methylcytidine (m5C)

In total 9 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000475		Click to Show/Hide the Full List
mod site	chr15:72199594-72199595:-		[8]
Sequence	ACCCCCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000564440.5; ENST00000335181.10; ENST00000449901.6; ENST00000565154.5; ENST00000565184.5; ENST00000389093.7; ENST00000319622.10; ENST00000565143.1; ENST00000567118.5; ENST00000568883.5
External Link	RMBase: m5C_site_14290
mod ID: M5CSITE000476		Click to Show/Hide the Full List
mod site	chr15:72202624-72202625:-		[8]
Sequence	CTCTGGACGGATGTTGCTCCCCTAGATTGCCCGTGAGGCAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000567118.5; ENST00000335181.10; ENST00000568459.5; ENST00000564440.5; ENST00000565184.5; ENST00000569857.5; ENST00000568883.5; ENST00000389093.7; ENST00000319622.10; ENST00000561609.5; ENST00000449901.6; ENST00000563986.1; ENST00000565154.5
External Link	RMBase: m5C_site_14291
mod ID: M5CSITE000477		Click to Show/Hide the Full List
mod site	chr15:72202626-72202627:-		[8]
Sequence	CCCTCTGGACGGATGTTGCTCCCCTAGATTGCCCGTGAGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000569857.5; ENST00000564440.5; ENST00000565154.5; ENST00000567118.5; ENST00000335181.10; ENST00000389093.7; ENST00000449901.6; ENST00000319622.10; ENST00000568459.5; ENST00000561609.5; ENST00000563986.1; ENST00000565184.5; ENST00000568883.5
External Link	RMBase: m5C_site_14292
mod ID: M5CSITE000478		Click to Show/Hide the Full List
mod site	chr15:72204236-72204237:-
Sequence	ACACTGGCCAACAGTTCCTTCCATTAACTGTTCACTGCTTT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000570166.1; ENST00000568459.5; ENST00000563986.1; ENST00000449901.6; ENST00000389093.7; ENST00000565184.5; ENST00000561609.5; ENST00000564440.5; ENST00000319622.10; ENST00000565154.5; ENST00000335181.10; ENST00000569857.5; ENST00000567118.5; ENST00000568883.5
External Link	RMBase: m5C_site_14293
mod ID: M5CSITE000479		Click to Show/Hide the Full List
mod site	chr15:72206131-72206132:-		[8]
Sequence	GCTGTGCCATTGGGGTACAGCTGCTGCTCTTACTCTAGACC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000319622.10; ENST00000389093.7; ENST00000565184.5; ENST00000335181.10; ENST00000567118.5; ENST00000561609.5; ENST00000449901.6; ENST00000568459.5; ENST00000563986.1; ENST00000570166.1; ENST00000569857.5; ENST00000568883.5; ENST00000565154.5
External Link	RMBase: m5C_site_14294
mod ID: M5CSITE000480		Click to Show/Hide the Full List
mod site	chr15:72206886-72206887:-		[8]
Sequence	TCTCACTAATGCTCTGTCCCCTCCCAGATGCTGGAGAGCAT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000319622.10; ENST00000389093.7; ENST00000568883.5; ENST00000561609.5; ENST00000335181.10; ENST00000564993.1; ENST00000563275.1; ENST00000569857.5; ENST00000449901.6; ENST00000565184.5; ENST00000565154.5; ENST00000568459.5; ENST00000567118.5
External Link	RMBase: m5C_site_14295
mod ID: M5CSITE000481		Click to Show/Hide the Full List
mod site	chr15:72209862-72209863:-		[8]
Sequence	TCTTGCTTACTCTCTTGTCCCTAGAGCGGCACTGCAGAGGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000562997.5; ENST00000568743.1; ENST00000319622.10; ENST00000564178.5; ENST00000565154.5; ENST00000562784.1; ENST00000449901.6; ENST00000335181.10; ENST00000565184.5; ENST00000567118.5; ENST00000568883.5; ENST00000569857.5; ENST00000561609.5; ENST00000389093.7; ENST00000568459.5; ENST00000567087.5
External Link	RMBase: m5C_site_14296
mod ID: M5CSITE000482		Click to Show/Hide the Full List
mod site	chr15:72219113-72219114:-		[8]
Sequence	CTCTTTCAATTTGTCTCGACCCAGGACCTCAGCAGCCATGT
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000564178.5; ENST00000335181.10; ENST00000567118.5; ENST00000567087.5; ENST00000561609.5; ENST00000568459.5; ENST00000565154.5; ENST00000389093.7; ENST00000566809.1; ENST00000449901.6; ENST00000569050.1; ENST00000565184.5; ENST00000562997.5; ENST00000569857.5; ENST00000319622.10; ENST00000568883.5; ENST00000564276.1
External Link	RMBase: m5C_site_14297
mod ID: M5CSITE000483		Click to Show/Hide the Full List
mod site	chr15:72219117-72219118:-		[8]
Sequence	CACTCTCTTTCAATTTGTCTCGACCCAGGACCTCAGCAGCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000335181.10; ENST00000566809.1; ENST00000568459.5; ENST00000449901.6; ENST00000565154.5; ENST00000561609.5; ENST00000565184.5; ENST00000567087.5; ENST00000567118.5; ENST00000568883.5; ENST00000564178.5; ENST00000569857.5; ENST00000562997.5; ENST00000569050.1; ENST00000319622.10; ENST00000564276.1; ENST00000389093.7
External Link	RMBase: m5C_site_14298

N6-methyladenosine (m6A)

In total 62 m6A sequence/site(s) in this target gene
mod ID: M6ASITE024058		Click to Show/Hide the Full List
mod site	chr15:72199044-72199045:-		[9]
Sequence	GCCTACCTGTATGTCAATAAACAACAGCTGAAGCACCTGTT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; HepG2; H1299; Huh7; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000568883.5; ENST00000565143.1; ENST00000565184.5; ENST00000389093.7; ENST00000335181.10; ENST00000319622.10; ENST00000564440.5; ENST00000449901.6
External Link	RMBase: m6A_site_286174
mod ID: M6ASITE024059		Click to Show/Hide the Full List
mod site	chr15:72199095-72199096:-		[10]
Sequence	ACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGCCTG
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000565184.5; ENST00000565143.1; ENST00000335181.10; ENST00000564440.5; ENST00000568883.5; ENST00000449901.6; ENST00000389093.7; ENST00000319622.10
External Link	RMBase: m6A_site_286175
mod ID: M6ASITE024060		Click to Show/Hide the Full List
mod site	chr15:72199098-72199099:-		[10]
Sequence	TCCACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGC
Motif Score	2.475107143
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000565143.1; ENST00000449901.6; ENST00000564440.5; ENST00000319622.10; ENST00000389093.7; ENST00000565184.5; ENST00000335181.10; ENST00000568883.5
External Link	RMBase: m6A_site_286176
mod ID: M6ASITE024061		Click to Show/Hide the Full List
mod site	chr15:72199129-72199130:-		[9]
Sequence	ACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; HepG2; A549; H1299; Huh7; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000319622.10; ENST00000335181.10; ENST00000564440.5; ENST00000567118.5; ENST00000568883.5; ENST00000389093.7; ENST00000565184.5; ENST00000565143.1; ENST00000449901.6
External Link	RMBase: m6A_site_286177
mod ID: M6ASITE024062		Click to Show/Hide the Full List
mod site	chr15:72199221-72199222:-		[10]
Sequence	CTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACT
Motif Score	3.287565476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000335181.10; ENST00000389093.7; ENST00000565143.1; ENST00000567118.5; ENST00000564440.5; ENST00000565184.5; ENST00000568883.5; ENST00000319622.10; ENST00000449901.6
External Link	RMBase: m6A_site_286178
mod ID: M6ASITE024063		Click to Show/Hide the Full List
mod site	chr15:72199277-72199278:-		[9]
Sequence	CCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; liver; H1A; H1B; A549; H1299; MM6; Huh7; peripheral-blood; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000567118.5; ENST00000319622.10; ENST00000564440.5; ENST00000449901.6; ENST00000335181.10; ENST00000389093.7; ENST00000568883.5; ENST00000565184.5; ENST00000565143.1
External Link	RMBase: m6A_site_286179
mod ID: M6ASITE024064		Click to Show/Hide the Full List
mod site	chr15:72199305-72199306:-		[9]
Sequence	AAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; A549; H1299; MM6; Huh7; peripheral-blood; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000335181.10; ENST00000564440.5; ENST00000565143.1; ENST00000568883.5; ENST00000449901.6; ENST00000319622.10; ENST00000565184.5; ENST00000567118.5; ENST00000389093.7
External Link	RMBase: m6A_site_286180
mod ID: M6ASITE024065		Click to Show/Hide the Full List
mod site	chr15:72199345-72199346:-		[10]
Sequence	CAGCTTCCTTTCCTGTGTGTACTCTGTCCAGTTCCTTTAGA
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000449901.6; ENST00000565184.5; ENST00000568883.5; ENST00000335181.10; ENST00000319622.10; ENST00000564440.5; ENST00000389093.7; ENST00000565143.1; ENST00000567118.5
External Link	RMBase: m6A_site_286181
mod ID: M6ASITE024066		Click to Show/Hide the Full List
mod site	chr15:72199366-72199367:-		[11]
Sequence	AGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGT
Motif Score	2.859755952
Cell/Tissue List	liver; HEK293T
Seq Type List	m6A-REF-seq; DART-seq
Transcript ID List	ENST00000389093.7; ENST00000565143.1; ENST00000564440.5; ENST00000568883.5; ENST00000319622.10; ENST00000449901.6; ENST00000567118.5; ENST00000565184.5; ENST00000335181.10
External Link	RMBase: m6A_site_286182
mod ID: M6ASITE024067		Click to Show/Hide the Full List
mod site	chr15:72199401-72199402:-		[9]
Sequence	GGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; H1A; H1B; A549; H1299; MM6; peripheral-blood; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List	ENST00000319622.10; ENST00000389093.7; ENST00000449901.6; ENST00000564440.5; ENST00000567118.5; ENST00000565143.1; ENST00000565184.5; ENST00000568883.5; ENST00000335181.10
External Link	RMBase: m6A_site_286183
mod ID: M6ASITE024068		Click to Show/Hide the Full List
mod site	chr15:72199467-72199468:-		[9]
Sequence	TTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; H1A; H1B; A549; H1299; MM6; Huh7; peripheral-blood; TREX; endometrial; HEC-1-A; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000568883.5; ENST00000319622.10; ENST00000389093.7; ENST00000565184.5; ENST00000567118.5; ENST00000449901.6; ENST00000565143.1; ENST00000564440.5; ENST00000335181.10
External Link	RMBase: m6A_site_286184
mod ID: M6ASITE024069		Click to Show/Hide the Full List
mod site	chr15:72199499-72199500:-		[9]
Sequence	AAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; H1A; H1B; A549; H1299; MM6; Huh7; peripheral-blood; TREX; endometrial; AML
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List	ENST00000564440.5; ENST00000565143.1; ENST00000389093.7; ENST00000319622.10; ENST00000568883.5; ENST00000335181.10; ENST00000449901.6; ENST00000567118.5; ENST00000565184.5
External Link	RMBase: m6A_site_286185
mod ID: M6ASITE024070		Click to Show/Hide the Full List
mod site	chr15:72199531-72199532:-		[9]
Sequence	CGTGGCACTGGTAGGTTGGGACACCAGGGAAGAAGATCAAC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; H1A; H1B; A549; H1299; MM6; Huh7; peripheral-blood; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List	ENST00000449901.6; ENST00000567118.5; ENST00000568883.5; ENST00000389093.7; ENST00000564440.5; ENST00000319622.10; ENST00000565143.1; ENST00000565184.5; ENST00000335181.10
External Link	RMBase: m6A_site_286186
mod ID: M6ASITE024071		Click to Show/Hide the Full List
mod site	chr15:72199552-72199553:-		[12]
Sequence	AGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGG
Motif Score	2.142029762
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000449901.6; ENST00000335181.10; ENST00000319622.10; ENST00000389093.7; ENST00000567118.5; ENST00000565143.1; ENST00000564440.5; ENST00000568883.5; ENST00000565184.5
External Link	RMBase: m6A_site_286187
mod ID: M6ASITE024072		Click to Show/Hide the Full List
mod site	chr15:72199565-72199566:-		[10]
Sequence	CAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCA
Motif Score	2.469291667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000389093.7; ENST00000567118.5; ENST00000565184.5; ENST00000319622.10; ENST00000449901.6; ENST00000335181.10; ENST00000568883.5; ENST00000564440.5; ENST00000565143.1
External Link	RMBase: m6A_site_286188
mod ID: M6ASITE024073		Click to Show/Hide the Full List
mod site	chr15:72199569-72199570:-		[9]
Sequence	AGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; CD8T; A549; H1299; MM6; Huh7; peripheral-blood; TREX; endometrial; AML
Seq Type List	m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List	ENST00000335181.10; ENST00000449901.6; ENST00000565143.1; ENST00000567118.5; ENST00000319622.10; ENST00000568883.5; ENST00000389093.7; ENST00000564440.5; ENST00000565184.5
External Link	RMBase: m6A_site_286189
mod ID: M6ASITE024074		Click to Show/Hide the Full List
mod site	chr15:72199580-72199581:-		[12]
Sequence	GCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTG
Motif Score	2.147845238
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000449901.6; ENST00000319622.10; ENST00000568883.5; ENST00000564440.5; ENST00000565184.5; ENST00000389093.7; ENST00000567118.5; ENST00000335181.10; ENST00000565143.1
External Link	RMBase: m6A_site_286190
mod ID: M6ASITE024075		Click to Show/Hide the Full List
mod site	chr15:72199645-72199646:-		[13]
Sequence	TTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAG
Motif Score	3.622404762
Cell/Tissue List	HepG2; A549; MM6; Huh7; peripheral-blood; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000568883.5; ENST00000565154.5; ENST00000389093.7; ENST00000567118.5; ENST00000565143.1; ENST00000564440.5; ENST00000568459.5; ENST00000565184.5; ENST00000319622.10; ENST00000449901.6; ENST00000335181.10
External Link	RMBase: m6A_site_286191
mod ID: M6ASITE024076		Click to Show/Hide the Full List
mod site	chr15:72199677-72199678:-		[14]
Sequence	CCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000565184.5; ENST00000335181.10; ENST00000565143.1; ENST00000564440.5; ENST00000568883.5; ENST00000319622.10; ENST00000568459.5; ENST00000389093.7; ENST00000565154.5; ENST00000449901.6; ENST00000567118.5
External Link	RMBase: m6A_site_286192
mod ID: M6ASITE024077		Click to Show/Hide the Full List
mod site	chr15:72200490-72200491:-		[15]
Sequence	GGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGGTA
Motif Score	3.373380952
Cell/Tissue List	CD34; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000335181.10; ENST00000568883.5; ENST00000567118.5; ENST00000565154.5; ENST00000319622.10; ENST00000389093.7; ENST00000565143.1; ENST00000568459.5; ENST00000565184.5; ENST00000564440.5; ENST00000449901.6
External Link	RMBase: m6A_site_286193
mod ID: M6ASITE024078		Click to Show/Hide the Full List
mod site	chr15:72200502-72200503:-		[13]
Sequence	GGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCA
Motif Score	3.622404762
Cell/Tissue List	HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000389093.7; ENST00000564440.5; ENST00000565154.5; ENST00000568883.5; ENST00000565184.5; ENST00000568459.5; ENST00000335181.10; ENST00000567118.5; ENST00000565143.1; ENST00000319622.10; ENST00000449901.6
External Link	RMBase: m6A_site_286194
mod ID: M6ASITE024079		Click to Show/Hide the Full List
mod site	chr15:72200535-72200536:-		[13]
Sequence	CTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGG
Motif Score	3.622404762
Cell/Tissue List	HepG2; MT4; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000568459.5; ENST00000335181.10; ENST00000449901.6; ENST00000565143.1; ENST00000565184.5; ENST00000565154.5; ENST00000567118.5; ENST00000389093.7; ENST00000564440.5; ENST00000561609.5; ENST00000319622.10; ENST00000568883.5
External Link	RMBase: m6A_site_286195
mod ID: M6ASITE024080		Click to Show/Hide the Full List
mod site	chr15:72200587-72200588:-		[13]
Sequence	CTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTG
Motif Score	2.897386905
Cell/Tissue List	HepG2; MT4; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000449901.6; ENST00000565184.5; ENST00000335181.10; ENST00000568883.5; ENST00000568459.5; ENST00000561609.5; ENST00000564440.5; ENST00000319622.10; ENST00000389093.7; ENST00000565154.5; ENST00000567118.5; ENST00000565143.1
External Link	RMBase: m6A_site_286196
mod ID: M6ASITE024081		Click to Show/Hide the Full List
mod site	chr15:72201409-72201410:-		[9]
Sequence	GCCCCTCCCCAGCTCCTGAGACACAGCTGCAGCTACAAGTG
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000561609.5; ENST00000449901.6; ENST00000568883.5; ENST00000564440.5; ENST00000389093.7; ENST00000335181.10; ENST00000565143.1; ENST00000567118.5; ENST00000565154.5; ENST00000319622.10; ENST00000565184.5; ENST00000568459.5
External Link	RMBase: m6A_site_286197
mod ID: M6ASITE024082		Click to Show/Hide the Full List
mod site	chr15:72202184-72202185:-		[10]
Sequence	ACATAACAGTGCACAGGCTGACTACAAATGGTTATTTGATA
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000565184.5; ENST00000561609.5; ENST00000563986.1; ENST00000567118.5; ENST00000568459.5; ENST00000319622.10; ENST00000564440.5; ENST00000449901.6; ENST00000565154.5; ENST00000389093.7; ENST00000335181.10; ENST00000568883.5
External Link	RMBase: m6A_site_286198
mod ID: M6ASITE024083		Click to Show/Hide the Full List
mod site	chr15:72202569-72202570:-		[9]
Sequence	CACTTGCAATTATTTGAGGAACTCCGCCGCCTGGCGCCCAT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; Huh7; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000561609.5; ENST00000568459.5; ENST00000565154.5; ENST00000335181.10; ENST00000567118.5; ENST00000568883.5; ENST00000389093.7; ENST00000563986.1; ENST00000565184.5; ENST00000319622.10; ENST00000449901.6; ENST00000569857.5; ENST00000564440.5
External Link	RMBase: m6A_site_286199
mod ID: M6ASITE024084		Click to Show/Hide the Full List
mod site	chr15:72202732-72202733:-		[9]
Sequence	CTTGGCCTTTGTTCCCAGGAACATGTTCCTCACCAGCTGTC
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000568459.5; ENST00000335181.10; ENST00000319622.10; ENST00000389093.7; ENST00000564440.5; ENST00000570166.1; ENST00000569857.5; ENST00000568883.5; ENST00000563986.1; ENST00000561609.5; ENST00000565154.5; ENST00000449901.6; ENST00000565184.5; ENST00000567118.5
External Link	RMBase: m6A_site_286200
mod ID: M6ASITE024085		Click to Show/Hide the Full List
mod site	chr15:72203112-72203113:-		[11]
Sequence	TGCGAGCCTCAAGTCACTCCACAGACCTCATGGAAGCCATG
Motif Score	2.053113095
Cell/Tissue List	brain; HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000563986.1; ENST00000319622.10; ENST00000565154.5; ENST00000389093.7; ENST00000449901.6; ENST00000570166.1; ENST00000567118.5; ENST00000335181.10; ENST00000568459.5; ENST00000564440.5; ENST00000565184.5; ENST00000561609.5; ENST00000569857.5; ENST00000568883.5
External Link	RMBase: m6A_site_286201
mod ID: M6ASITE024086		Click to Show/Hide the Full List
mod site	chr15:72203320-72203321:-		[9]
Sequence	CCTCTGCATCTGCCTGAAGGACAGATTTAGCCAATTAACCT
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000389093.7; ENST00000563986.1; ENST00000561609.5; ENST00000568459.5; ENST00000564440.5; ENST00000570166.1; ENST00000567118.5; ENST00000335181.10; ENST00000449901.6; ENST00000565154.5; ENST00000568883.5; ENST00000565184.5; ENST00000569857.5; ENST00000319622.10
External Link	RMBase: m6A_site_286202
mod ID: M6ASITE024087		Click to Show/Hide the Full List
mod site	chr15:72203355-72203356:-		[9]
Sequence	GCACCTCCTGAAGCAGTTGGACTTTCATCACCCTACCTCTG
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000563986.1; ENST00000449901.6; ENST00000570166.1; ENST00000561609.5; ENST00000567118.5; ENST00000319622.10; ENST00000569857.5; ENST00000565154.5; ENST00000389093.7; ENST00000565184.5; ENST00000335181.10; ENST00000568883.5; ENST00000568459.5; ENST00000564440.5
External Link	RMBase: m6A_site_286203
mod ID: M6ASITE024088		Click to Show/Hide the Full List
mod site	chr15:72206761-72206762:-		[9]
Sequence	TGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000570166.1; ENST00000564993.1; ENST00000389093.7; ENST00000569857.5; ENST00000565184.5; ENST00000567118.5; ENST00000565154.5; ENST00000568883.5; ENST00000568459.5; ENST00000561609.5; ENST00000335181.10; ENST00000563986.1; ENST00000563275.1; ENST00000319622.10; ENST00000449901.6
External Link	RMBase: m6A_site_286204
mod ID: M6ASITE024089		Click to Show/Hide the Full List
mod site	chr15:72206774-72206775:-		[9]
Sequence	GCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCT
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000565184.5; ENST00000568883.5; ENST00000568459.5; ENST00000563275.1; ENST00000319622.10; ENST00000570166.1; ENST00000449901.6; ENST00000567118.5; ENST00000564993.1; ENST00000561609.5; ENST00000335181.10; ENST00000389093.7; ENST00000569857.5; ENST00000565154.5; ENST00000563986.1
External Link	RMBase: m6A_site_286205
mod ID: M6ASITE024090		Click to Show/Hide the Full List
mod site	chr15:72208665-72208666:-		[9]
Sequence	CCTGGGAGAGAAGGGAAAGAACATCAAGATTATCAGCAAAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000568883.5; ENST00000568459.5; ENST00000449901.6; ENST00000565154.5; ENST00000561609.5; ENST00000569857.5; ENST00000567118.5; ENST00000389093.7; ENST00000319622.10; ENST00000565184.5; ENST00000335181.10; ENST00000568743.1; ENST00000563275.1
External Link	RMBase: m6A_site_286206
mod ID: M6ASITE024091		Click to Show/Hide the Full List
mod site	chr15:72208782-72208783:-		[9]
Sequence	GCCTGCTGTGTCGGAGAAGGACATCCAGGATCTGAAGTTTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000568883.5; ENST00000319622.10; ENST00000335181.10; ENST00000563275.1; ENST00000569857.5; ENST00000567118.5; ENST00000565154.5; ENST00000568743.1; ENST00000568459.5; ENST00000449901.6; ENST00000561609.5; ENST00000565184.5; ENST00000389093.7
External Link	RMBase: m6A_site_286207
mod ID: M6ASITE024092		Click to Show/Hide the Full List
mod site	chr15:72208806-72208807:-		[9]
Sequence	CCTTCCTGGGGCTGCTGTGGACTTGCCTGCTGTGTCGGAGA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial; NB4; MM6; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000568459.5; ENST00000565154.5; ENST00000449901.6; ENST00000565184.5; ENST00000563275.1; ENST00000561609.5; ENST00000335181.10; ENST00000569857.5; ENST00000568883.5; ENST00000319622.10; ENST00000567118.5; ENST00000568743.1; ENST00000389093.7
External Link	RMBase: m6A_site_286208
mod ID: M6ASITE024093		Click to Show/Hide the Full List
mod site	chr15:72208827-72208828:-		[9]
Sequence	GGGCAGCAAGAAGGGTGTGAACCTTCCTGGGGCTGCTGTGG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000563275.1; ENST00000567118.5; ENST00000568883.5; ENST00000389093.7; ENST00000335181.10; ENST00000565154.5; ENST00000568743.1; ENST00000319622.10; ENST00000568459.5; ENST00000565184.5; ENST00000561609.5; ENST00000569857.5; ENST00000449901.6
External Link	RMBase: m6A_site_286209
mod ID: M6ASITE024094		Click to Show/Hide the Full List
mod site	chr15:72209620-72209621:-		[9]
Sequence	AAACAGTCTTTTGTCTCTAAACTTCCTTGACACAAGGAAGA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000389093.7; ENST00000569857.5; ENST00000565184.5; ENST00000335181.10; ENST00000449901.6; ENST00000319622.10; ENST00000568743.1; ENST00000565154.5; ENST00000567118.5; ENST00000568459.5; ENST00000568883.5; ENST00000562784.1; ENST00000561609.5
External Link	RMBase: m6A_site_286210
mod ID: M6ASITE024095		Click to Show/Hide the Full List
mod site	chr15:72209638-72209639:-		[9]
Sequence	CTGGAGTCCAGTTGTCTAAAACAGTCTTTTGTCTCTAAACT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; peripheral-blood; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000567118.5; ENST00000569857.5; ENST00000568743.1; ENST00000449901.6; ENST00000568459.5; ENST00000335181.10; ENST00000389093.7; ENST00000565154.5; ENST00000561609.5; ENST00000565184.5; ENST00000568883.5; ENST00000319622.10; ENST00000562784.1
External Link	RMBase: m6A_site_286211
mod ID: M6ASITE024096		Click to Show/Hide the Full List
mod site	chr15:72209749-72209750:-		[9]
Sequence	CCTGTGGCTGGACTACAAGAACATCTGCAAGGTGGTGGAAG
Motif Score	2.951386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; peripheral-blood; endometrial; NB4; MM6
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000389093.7; ENST00000568459.5; ENST00000335181.10; ENST00000568743.1; ENST00000567118.5; ENST00000319622.10; ENST00000562784.1; ENST00000565184.5; ENST00000561609.5; ENST00000449901.6; ENST00000569857.5; ENST00000565154.5; ENST00000568883.5; ENST00000564178.5
External Link	RMBase: m6A_site_286212
mod ID: M6ASITE024097		Click to Show/Hide the Full List
mod site	chr15:72209758-72209759:-		[9]
Sequence	CGAGAACATCCTGTGGCTGGACTACAAGAACATCTGCAAGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000568743.1; ENST00000335181.10; ENST00000449901.6; ENST00000319622.10; ENST00000568459.5; ENST00000561609.5; ENST00000562784.1; ENST00000567118.5; ENST00000565184.5; ENST00000565154.5; ENST00000564178.5; ENST00000568883.5; ENST00000562997.5; ENST00000569857.5; ENST00000389093.7
External Link	RMBase: m6A_site_286213
mod ID: M6ASITE024098		Click to Show/Hide the Full List
mod site	chr15:72209773-72209774:-		[9]
Sequence	CATGGAAAAGTGTGACGAGAACATCCTGTGGCTGGACTACA
Motif Score	2.951386905
Cell/Tissue List	HeLa; kidney; liver; HepG2; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq; m6A-REF-seq
Transcript ID List	ENST00000568743.1; ENST00000565184.5; ENST00000568459.5; ENST00000562784.1; ENST00000568883.5; ENST00000561609.5; ENST00000319622.10; ENST00000567118.5; ENST00000449901.6; ENST00000564178.5; ENST00000335181.10; ENST00000389093.7; ENST00000569857.5; ENST00000562997.5; ENST00000565154.5
External Link	RMBase: m6A_site_286214
mod ID: M6ASITE024099		Click to Show/Hide the Full List
mod site	chr15:72209794-72209795:-		[11]
Sequence	AATCACGCTGGATAACGCCTACATGGAAAAGTGTGACGAGA
Motif Score	2.078666667
Cell/Tissue List	kidney; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000389093.7; ENST00000562784.1; ENST00000561609.5; ENST00000568883.5; ENST00000569857.5; ENST00000335181.10; ENST00000562997.5; ENST00000567118.5; ENST00000567087.5; ENST00000319622.10; ENST00000568459.5; ENST00000564178.5; ENST00000565154.5; ENST00000568743.1; ENST00000449901.6; ENST00000565184.5
External Link	RMBase: m6A_site_286215
mod ID: M6ASITE024100		Click to Show/Hide the Full List
mod site	chr15:72209884-72209885:-		[9]
Sequence	TACTGGTGTCTCCAGTTTGGACTCTTGCTTACTCTCTTGTC
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; peripheral-blood; HEK293T; endometrial; NB4; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000562784.1; ENST00000568883.5; ENST00000567087.5; ENST00000567118.5; ENST00000568459.5; ENST00000449901.6; ENST00000564178.5; ENST00000561609.5; ENST00000565184.5; ENST00000335181.10; ENST00000319622.10; ENST00000565154.5; ENST00000568743.1; ENST00000389093.7; ENST00000569857.5; ENST00000562997.5
External Link	RMBase: m6A_site_286216
mod ID: M6ASITE024101		Click to Show/Hide the Full List
mod site	chr15:72209983-72209984:-		[9]
Sequence	TTAGAGAATAAGAGCAAAAAACTGTATTACTTTTAGCAGTG
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000561609.5; ENST00000565184.5; ENST00000567087.5; ENST00000449901.6; ENST00000335181.10; ENST00000568883.5; ENST00000319622.10; ENST00000389093.7; ENST00000564178.5; ENST00000568459.5; ENST00000562784.1; ENST00000562997.5; ENST00000567118.5; ENST00000569857.5; ENST00000565154.5; ENST00000568743.1
External Link	RMBase: m6A_site_286217
mod ID: M6ASITE024102		Click to Show/Hide the Full List
mod site	chr15:72210291-72210292:-		[16]
Sequence	GTAGGCAATATGCCCCAGAGACATGTCCTCCAAAGCGCTGG
Motif Score	2.897386905
Cell/Tissue List	HepG2
Seq Type List	m6A-seq
Transcript ID List	ENST00000568459.5; ENST00000319622.10; ENST00000562997.5; ENST00000561609.5; ENST00000564276.1; ENST00000562784.1; ENST00000389093.7; ENST00000565154.5; ENST00000564178.5; ENST00000567087.5; ENST00000568883.5; ENST00000569857.5; ENST00000335181.10; ENST00000449901.6; ENST00000565184.5; ENST00000567118.5
External Link	RMBase: m6A_site_286218
mod ID: M6ASITE024103		Click to Show/Hide the Full List
mod site	chr15:72210363-72210364:-		[9]
Sequence	CTAAAGGACCTGAGATCCGAACTGGGCTCATCAAGGGCGTG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000564276.1; ENST00000567118.5; ENST00000564178.5; ENST00000568459.5; ENST00000561609.5; ENST00000562784.1; ENST00000449901.6; ENST00000335181.10; ENST00000562997.5; ENST00000568883.5; ENST00000319622.10; ENST00000569857.5; ENST00000565154.5; ENST00000565184.5; ENST00000389093.7; ENST00000567087.5
External Link	RMBase: m6A_site_286219
mod ID: M6ASITE024104		Click to Show/Hide the Full List
mod site	chr15:72210376-72210377:-		[9]
Sequence	GTGGCTCTAGACACTAAAGGACCTGAGATCCGAACTGGGCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000568459.5; ENST00000564178.5; ENST00000565154.5; ENST00000564276.1; ENST00000569857.5; ENST00000389093.7; ENST00000449901.6; ENST00000561609.5; ENST00000565184.5; ENST00000335181.10; ENST00000567118.5; ENST00000568883.5; ENST00000562784.1; ENST00000319622.10; ENST00000567087.5; ENST00000562997.5
External Link	RMBase: m6A_site_286220
mod ID: M6ASITE024105		Click to Show/Hide the Full List
mod site	chr15:72210386-72210387:-		[9]
Sequence	GCCCGTTGCTGTGGCTCTAGACACTAAAGGACCTGAGATCC
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000562997.5; ENST00000389093.7; ENST00000562784.1; ENST00000449901.6; ENST00000564276.1; ENST00000565154.5; ENST00000569857.5; ENST00000568459.5; ENST00000565184.5; ENST00000567087.5; ENST00000568883.5; ENST00000561609.5; ENST00000319622.10; ENST00000567118.5; ENST00000335181.10; ENST00000564178.5
External Link	RMBase: m6A_site_286221
mod ID: M6ASITE024106		Click to Show/Hide the Full List
mod site	chr15:72210465-72210466:-		[9]
Sequence	TCCCCCAGTACCATGCGGAGACCATCAAGAATGTGCGCACA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial; AML
Seq Type List	m6A-seq; miCLIP
Transcript ID List	ENST00000449901.6; ENST00000569857.5; ENST00000335181.10; ENST00000389093.7; ENST00000319622.10; ENST00000568883.5; ENST00000564178.5; ENST00000562997.5; ENST00000564276.1; ENST00000567118.5; ENST00000565184.5; ENST00000567087.5; ENST00000565154.5; ENST00000562784.1; ENST00000561609.5; ENST00000568459.5
External Link	RMBase: m6A_site_286222
mod ID: M6ASITE024107		Click to Show/Hide the Full List
mod site	chr15:72217416-72217417:-		[9]
Sequence	GTCTGAACTTCTCTCATGGAACTCATGAGGTGAGCTGTGGC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000566809.1; ENST00000562784.1; ENST00000567087.5; ENST00000319622.10; ENST00000561609.5; ENST00000335181.10; ENST00000564178.5; ENST00000569857.5; ENST00000565154.5; ENST00000568883.5; ENST00000564276.1; ENST00000389093.7; ENST00000449901.6; ENST00000568459.5; ENST00000567118.5; ENST00000562997.5; ENST00000565184.5
External Link	RMBase: m6A_site_286223
mod ID: M6ASITE024108		Click to Show/Hide the Full List
mod site	chr15:72217430-72217431:-		[9]
Sequence	AATGAATGTGGCTCGTCTGAACTTCTCTCATGGAACTCATG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; peripheral-blood; endometrial; MM6
Seq Type List	m6A-seq
Transcript ID List	ENST00000567087.5; ENST00000567118.5; ENST00000565154.5; ENST00000565184.5; ENST00000449901.6; ENST00000561609.5; ENST00000562997.5; ENST00000335181.10; ENST00000562784.1; ENST00000389093.7; ENST00000568883.5; ENST00000569857.5; ENST00000564178.5; ENST00000566809.1; ENST00000564276.1; ENST00000319622.10; ENST00000568459.5
External Link	RMBase: m6A_site_286224
mod ID: M6ASITE024109		Click to Show/Hide the Full List
mod site	chr15:72218966-72218967:-		[9]
Sequence	ACCACCCATCACAGCCCGGAACACTGGCATCATCTGTACCA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; MT4; CD4T; peripheral-blood; endometrial; MM6; AML
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000568459.5; ENST00000567118.5; ENST00000319622.10; ENST00000389093.7; ENST00000565154.5; ENST00000564276.1; ENST00000449901.6; ENST00000562997.5; ENST00000566809.1; ENST00000567087.5; ENST00000335181.10; ENST00000565184.5; ENST00000561609.5; ENST00000569050.1; ENST00000569857.5; ENST00000564178.5; ENST00000568883.5
External Link	RMBase: m6A_site_286225
mod ID: M6ASITE024110		Click to Show/Hide the Full List
mod site	chr15:72218996-72218997:-		[9]
Sequence	GGAGCACATGTGCCGCCTGGACATTGATTCACCACCCATCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; MT4; CD4T; peripheral-blood; HEK293T; endometrial; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000319622.10; ENST00000335181.10; ENST00000569857.5; ENST00000567118.5; ENST00000564178.5; ENST00000449901.6; ENST00000565154.5; ENST00000564276.1; ENST00000568459.5; ENST00000566809.1; ENST00000389093.7; ENST00000567087.5; ENST00000569050.1; ENST00000562997.5; ENST00000561609.5; ENST00000565184.5; ENST00000568883.5
External Link	RMBase: m6A_site_286226
mod ID: M6ASITE024111		Click to Show/Hide the Full List
mod site	chr15:72219026-72219027:-		[14]
Sequence	GCTGCACGCAGCCATGGCTGACACATTCCTGGAGCACATGT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000568883.5; ENST00000567087.5; ENST00000569050.1; ENST00000319622.10; ENST00000564276.1; ENST00000567118.5; ENST00000569857.5; ENST00000568459.5; ENST00000565154.5; ENST00000335181.10; ENST00000561609.5; ENST00000562997.5; ENST00000449901.6; ENST00000565184.5; ENST00000389093.7; ENST00000564178.5; ENST00000566809.1
External Link	RMBase: m6A_site_286227
mod ID: M6ASITE024112		Click to Show/Hide the Full List
mod site	chr15:72219054-72219055:-		[9]
Sequence	CCGGGACTGCCTTCATTCAGACCCAGCAGCTGCACGCAGCC
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000564178.5; ENST00000565184.5; ENST00000389093.7; ENST00000335181.10; ENST00000561609.5; ENST00000568459.5; ENST00000564276.1; ENST00000569050.1; ENST00000562997.5; ENST00000569857.5; ENST00000567087.5; ENST00000319622.10; ENST00000565154.5; ENST00000566809.1; ENST00000449901.6; ENST00000567118.5; ENST00000568883.5
External Link	RMBase: m6A_site_286228
mod ID: M6ASITE024113		Click to Show/Hide the Full List
mod site	chr15:72219069-72219070:-		[9]
Sequence	AGCCCCATAGTGAAGCCGGGACTGCCTTCATTCAGACCCAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; MT4; Huh7; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000568883.5; ENST00000389093.7; ENST00000565184.5; ENST00000569050.1; ENST00000567118.5; ENST00000569857.5; ENST00000564276.1; ENST00000449901.6; ENST00000335181.10; ENST00000562997.5; ENST00000568459.5; ENST00000565154.5; ENST00000566809.1; ENST00000564178.5; ENST00000319622.10; ENST00000561609.5; ENST00000567087.5
External Link	RMBase: m6A_site_286229
mod ID: M6ASITE024114		Click to Show/Hide the Full List
mod site	chr15:72221173-72221174:-		[9]
Sequence	CGGAAGCCCAACCCCAGAGAACCAAAGGTATGACCTGATAT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; MT4; A549; MM6; CD4T; peripheral-blood; HEK293T; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000564276.1; ENST00000568883.5; ENST00000567118.5; ENST00000568459.5; ENST00000389093.7; ENST00000335181.10; ENST00000562997.5; ENST00000569050.1; ENST00000566809.1; ENST00000565184.5; ENST00000565154.5; ENST00000449901.6; ENST00000319622.10; ENST00000561609.5; ENST00000569857.5; ENST00000567087.5
External Link	RMBase: m6A_site_286230
mod ID: M6ASITE024115		Click to Show/Hide the Full List
mod site	chr15:72231551-72231552:-		[9]
Sequence	GGGCCGAGAGCCAAGAAAAGACACCCCATCTGGCAGCCCAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; HEK293A-TOA; iSLK; MSC; TREX; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000566809.1; ENST00000569050.1; ENST00000568883.5; ENST00000567087.5
External Link	RMBase: m6A_site_286231
mod ID: M6ASITE024116		Click to Show/Hide the Full List
mod site	chr15:72231587-72231588:-		[9]
Sequence	CCCTGCCCAGGTAGGCCGGGACAGCTGGGGTGGCCTGGGCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; HEK293A-TOA; iSLK; MSC; TREX; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000568883.5; ENST00000569050.1; ENST00000567087.5; ENST00000566809.1
External Link	RMBase: m6A_site_286232
mod ID: M6ASITE024117		Click to Show/Hide the Full List
mod site	chr15:72231622-72231623:-		[9]
Sequence	CGGGAGAATGCTGCCCCGGAACCCATAAATCTGGGCCCTGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; HEK293A-TOA; iSLK; MSC; TREX; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000566809.1; ENST00000569050.1; ENST00000567087.5; ENST00000568883.5
External Link	RMBase: m6A_site_286233
mod ID: M6ASITE024118		Click to Show/Hide the Full List
mod site	chr15:72231676-72231677:-		[9]
Sequence	CCGAGGGTGCGCCAGAGCAGACACCCGGAGGAGTGGGGAGT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; H1A; H1B; GM12878; MM6; CD4T; HEK293A-TOA; MSC; TIME; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000569050.1; ENST00000567087.5; ENST00000568883.5
External Link	RMBase: m6A_site_286234
mod ID: M6ASITE024119		Click to Show/Hide the Full List
mod site	chr15:72231752-72231753:-		[9]
Sequence	CCCCTCCGAAGGCGGCCAGGACCTCCAACCACGCACAAGTC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; HepG2; H1A; H1B; hNPCs; GM12878; MM6; CD4T; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000568883.5; ENST00000569050.1
External Link	RMBase: m6A_site_286235

2'-O-Methylation (2'-O-Me)

In total 3 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000124		Click to Show/Hide the Full List
mod site	chr15:72199333-72199334:-		[17]
Sequence	CTGTGTGTACTCTGTCCAGTTCCTTTAGAAAAAATGGATGC
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000389093.7; ENST00000319622.10; ENST00000568883.5; ENST00000565184.5; ENST00000449901.6; ENST00000564440.5; ENST00000567118.5; ENST00000335181.10; ENST00000565143.1
External Link	RMBase: Nm_site_1966
mod ID: 2OMSITE000125		Click to Show/Hide the Full List
mod site	chr15:72207129-72207130:-		[17]
Sequence	AAGCCTGTCATCTGTGCTACTCAGGCATGTGCCCACCCTTC
Cell/Tissue List	HEK293
Seq Type List	Nm-seq
Transcript ID List	ENST00000567118.5; ENST00000563275.1; ENST00000389093.7; ENST00000564993.1; ENST00000335181.10; ENST00000569857.5; ENST00000561609.5; ENST00000568459.5; ENST00000449901.6; ENST00000565184.5; ENST00000319622.10; ENST00000565154.5; ENST00000568883.5
External Link	RMBase: Nm_site_1967
mod ID: 2OMSITE000126		Click to Show/Hide the Full List
mod site	chr15:72210477-72210478:-		[17]
Sequence	TCTTCCTTCTTTTCCCCCAGTACCATGCGGAGACCATCAAG
Cell/Tissue List	HEK293; HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000389093.7; ENST00000568459.5; ENST00000567087.5; ENST00000564276.1; ENST00000565184.5; ENST00000564178.5; ENST00000568883.5; ENST00000567118.5; ENST00000561609.5; ENST00000562784.1; ENST00000449901.6; ENST00000335181.10; ENST00000565154.5; ENST00000319622.10; ENST00000569857.5; ENST00000562997.5
External Link	RMBase: Nm_site_1968

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000064		Click to Show/Hide the Full List
mod site	chr15:72200295-72200296:-		[18]
Sequence	GTTCATTCTGAATCTCTCATTCTCCGAAGTCCTAAGCTGAG
Transcript ID List	ENST00000565184.5; ENST00000568883.5; ENST00000565154.5; ENST00000449901.6; ENST00000335181.10; ENST00000319622.10; ENST00000568459.5; ENST00000565143.1; ENST00000389093.7; ENST00000564440.5; ENST00000567118.5
External Link	RMBase: Pseudo_site_1665

Ref 1	m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation. Am J Transl Res. 2019 Sep 15;11(9):6084-6092. eCollection 2019.
Ref 2	YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis. Cell Death Dis. 2022 Mar 23;13(3):258. doi: 10.1038/s41419-022-04711-1.
Ref 3	ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m(6)A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity. J Oncol. 2021 Dec 30;2021:1328444. doi: 10.1155/2021/1328444. eCollection 2021.
Ref 4	Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
Ref 5	Differential selectivity of efflux transporter inhibitors in Caco-2 and MDCK-MDR1 monolayers: a strategy to assess the interaction of a new chemical entity with P-gp, BCRP, and MRP2. J Pharm Sci. 2012 May;101(5):1888-97.
Ref 6	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 7	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 8	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 9	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 10	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 11	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 12	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 13	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 14	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 15	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 16	Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.
Ref 17	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.
Ref 18	Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014 Nov 6;515(7525):143-6. doi: 10.1038/nature13802. Epub 2014 Sep 5.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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