m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00285)

Target Name	DNA-binding protein inhibitor ID-2 (ID2)
Synonyms	Class B basic helix-loop-helix protein 26; bHLHb26; Inhibitor of DNA binding 2; Inhibitor of differentiation 2; BHLHB26 Click to Show/Hide
Gene Name	ID2
Chromosomal Location	2p25.1
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. Click to Show/Hide
Gene ID	3398
Uniprot ID	ID2_HUMAN
HGNC ID	HGNC:5361
KEGG ID	hsa:3398

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

ID2 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Protein virilizer homolog (VIRMA) [WRITER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	KIAA1429 facilitated migration and invasion of Hepatocellular carcinoma cells by inhibiting DNA-binding protein inhibitor ID-2 (ID2) via upregulating m6A modification of ID2 mRNA.
Target Regulation	Up regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Pathway Response	RNA degradation			hsa03018
Cell Process	Cell migration and invasion
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	Hep-G2/2.2.15	Hepatoblastoma	Homo sapiens	CVCL_L855
	L-02	Endocervical adenocarcinoma	Homo sapiens	CVCL_6926
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336

Liver cancer [ICD-11: 2C12]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[2]
Response Summary	KIAA1429 facilitated migration and invasion of Hepatocellular carcinoma cells by inhibiting DNA-binding protein inhibitor ID-2 (ID2) via upregulating m6A modification of ID2 mRNA.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	Protein virilizer homolog (VIRMA)		WRITER	Regulator Info
Target Regulation	Up regulation
Pathway Response	RNA degradation			hsa03018
Cell Process	Cell migration and invasion
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	Hep-G2/2.2.15	Hepatoblastoma	Homo sapiens	CVCL_L855
	L-02	Endocervical adenocarcinoma	Homo sapiens	CVCL_6926
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens	CVCL_0336

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

RNA modification

m6A Regulator: Protein virilizer homolog (VIRMA)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00532		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	MicroRNA 19a (MIR19A)
Crosstalk relationship	A-to-I → m6A

DNA modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02119		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Pancreatic cancer	Disease Info
Crosstalk ID: M6ACROT02128		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Pancreatic cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00285)

DNA-binding protein inhibitor ID-2 (ID2)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000010		Click to Show/Hide the Full List
mod site	chr2:8682257-8682258:+
Sequence	AGCAAAACCCCTGTGGACGACCCGATGAGCCTGCTATACAA
Cell/Tissue List	DLD1
Seq Type List	acRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000331129.3; ENST00000396290.2
External Link	RMBase: ac4C_site_1067

N6-methyladenosine (m6A)

In total 39 m6A sequence/site(s) in this target gene
mod ID: M6ASITE042773		Click to Show/Hide the Full List
mod site	chr2:8679074-8679075:+		[3]
Sequence	CGGGGTCACGGGCGGAATGGACACAGCTGTGAGAACAAAAC
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000234091.8
External Link	RMBase: m6A_site_459641
mod ID: M6ASITE042774		Click to Show/Hide the Full List
mod site	chr2:8679088-8679089:+		[3]
Sequence	GAATGGACACAGCTGTGAGAACAAAACCCGGGAAAGAAAGG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000234091.8
External Link	RMBase: m6A_site_459642
mod ID: M6ASITE042775		Click to Show/Hide the Full List
mod site	chr2:8679093-8679094:+		[3]
Sequence	GACACAGCTGTGAGAACAAAACCCGGGAAAGAAAGGCGAAC
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000234091.8
External Link	RMBase: m6A_site_459643
mod ID: M6ASITE042776		Click to Show/Hide the Full List
mod site	chr2:8679144-8679145:+		[3]
Sequence	GCGCCAGATGTGCAGGGAGGACCTTGAGACGCGCCCCCCGC
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000234091.8
External Link	RMBase: m6A_site_459644
mod ID: M6ASITE042777		Click to Show/Hide the Full List
mod site	chr2:8682202-8682203:+		[3]
Sequence	CGTGAGGTCCGTTAGGAAAAACAGCCTGTCGGACCACAGCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; TREX; endometrial; HEC-1-A; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000331129.3; ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459645
mod ID: M6ASITE042778		Click to Show/Hide the Full List
mod site	chr2:8682214-8682215:+		[3]
Sequence	TAGGAAAAACAGCCTGTCGGACCACAGCCTGGGCATCTCCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; TREX; endometrial; HEC-1-A; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000331129.3; ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459646
mod ID: M6ASITE042779		Click to Show/Hide the Full List
mod site	chr2:8682243-8682244:+		[4]
Sequence	TGGGCATCTCCCGGAGCAAAACCCCTGTGGACGACCCGATG
Motif Score	2.185083333
Cell/Tissue List	HepG2; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293T; iSLK; MSC; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000331129.3; ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459647
mod ID: M6ASITE042780		Click to Show/Hide the Full List
mod site	chr2:8682274-8682275:+		[5]
Sequence	CGACCCGATGAGCCTGCTATACAACATGAACGACTGCTACT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2; ENST00000331129.3
External Link	RMBase: m6A_site_459648
mod ID: M6ASITE042781		Click to Show/Hide the Full List
mod site	chr2:8682277-8682278:+		[5]
Sequence	CCCGATGAGCCTGCTATACAACATGAACGACTGCTACTCCA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000234091.8; ENST00000331129.3; ENST00000396290.2
External Link	RMBase: m6A_site_459649
mod ID: M6ASITE042782		Click to Show/Hide the Full List
mod site	chr2:8682331-8682332:+		[4]
Sequence	GGTGCCCAGCATCCCCCAGAACAAGAAGGTGAGCAAGATGG
Motif Score	2.951386905
Cell/Tissue List	HepG2; A549; hESC-HEK293T; MM6; Huh7; Jurkat; CD4T; peripheral-blood; MSC; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000234091.8; ENST00000331129.3; ENST00000396290.2
External Link	RMBase: m6A_site_459650
mod ID: M6ASITE042783		Click to Show/Hide the Full List
mod site	chr2:8682376-8682377:+		[5]
Sequence	CCTGCAGCACGTCATCGACTACATCTTGGACCTGCAGATCG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000396290.2; ENST00000234091.8; ENST00000331129.3
External Link	RMBase: m6A_site_459651
mod ID: M6ASITE042784		Click to Show/Hide the Full List
mod site	chr2:8682385-8682386:+		[6]
Sequence	CGTCATCGACTACATCTTGGACCTGCAGATCGCCCTGGACT
Motif Score	3.622404762
Cell/Tissue List	HepG2; Huh7; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000396290.2; ENST00000331129.3; ENST00000234091.8
External Link	RMBase: m6A_site_459652
mod ID: M6ASITE042785		Click to Show/Hide the Full List
mod site	chr2:8682403-8682404:+		[6]
Sequence	GGACCTGCAGATCGCCCTGGACTCGCATCCCACTATTGTCA
Motif Score	4.065041667
Cell/Tissue List	HepG2; Huh7; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2; ENST00000331129.3
External Link	RMBase: m6A_site_459653
mod ID: M6ASITE042786		Click to Show/Hide the Full List
mod site	chr2:8682440-8682441:+		[6]
Sequence	GTCAGCCTGCATCACCAGAGACCCGGGCAGAACCAGGCGTC
Motif Score	2.876744048
Cell/Tissue List	HepG2; Huh7; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000396290.2; ENST00000331129.3; ENST00000234091.8
External Link	RMBase: m6A_site_459654
mod ID: M6ASITE042787		Click to Show/Hide the Full List
mod site	chr2:8682451-8682452:+		[6]
Sequence	TCACCAGAGACCCGGGCAGAACCAGGCGTCCAGGACGCCGC
Motif Score	2.930744048
Cell/Tissue List	HepG2; Huh7; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000331129.3; ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459655
mod ID: M6ASITE042788		Click to Show/Hide the Full List
mod site	chr2:8682484-8682485:+		[5]
Sequence	GACGCCGCTGACCACCCTCAACACGGATATCAGCATCCTGT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000234091.8; ENST00000331129.3; ENST00000396290.2
External Link	RMBase: m6A_site_459656
mod ID: M6ASITE042789		Click to Show/Hide the Full List
mod site	chr2:8682786-8682787:+
Sequence	AAAAAAAAAAAAAAAAAAAAACCCTTTCTACTTAACATTGT
Motif Score	2.185083333
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000331129.3; rmsk_458024; ENST00000396290.2; ENST00000234091.8; ENST00000472142.1
External Link	RMBase: m6A_site_459657
mod ID: M6ASITE042790		Click to Show/Hide the Full List
mod site	chr2:8682937-8682938:+		[7]
Sequence	CTTGTGCCACCCGTGGGTAAACTGCCCCTCGGTGTGTGTGC
Motif Score	2.627720238
Cell/Tissue List	HEK293T; GM12878; Huh7
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000472142.1; ENST00000331129.3; ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459658
mod ID: M6ASITE042791		Click to Show/Hide the Full List
mod site	chr2:8683711-8683712:+		[5]
Sequence	TGATTTCTTTTATTCTTTGCACAACAACAACAACAACAAAT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000234091.8; rmsk_458025; ENST00000396290.2; ENST00000472142.1
External Link	RMBase: m6A_site_459659
mod ID: M6ASITE042792		Click to Show/Hide the Full List
mod site	chr2:8683726-8683727:+		[5]
Sequence	TTTGCACAACAACAACAACAACAAATTCACGGAATCTTTTA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2; rmsk_458025; ENST00000472142.1
External Link	RMBase: m6A_site_459660
mod ID: M6ASITE042793		Click to Show/Hide the Full List
mod site	chr2:8683755-8683756:+		[3]
Sequence	CGGAATCTTTTAAGTGCTGAACTTATTTTTCAACCATTTCA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; hNPCs; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000472142.1; ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459661
mod ID: M6ASITE042794		Click to Show/Hide the Full List
mod site	chr2:8683775-8683776:+		[8]
Sequence	ACTTATTTTTCAACCATTTCACAAGGAGGACAAGTTGAATG
Motif Score	2.047297619
Cell/Tissue List	brain; HEK293; liver; HEK293T; hESC-HEK293T
Seq Type List	m6A-REF-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000396290.2; ENST00000472142.1; ENST00000234091.8
External Link	RMBase: m6A_site_459662
mod ID: M6ASITE042795		Click to Show/Hide the Full List
mod site	chr2:8683784-8683785:+		[3]
Sequence	TCAACCATTTCACAAGGAGGACAAGTTGAATGGACCTTTTT
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; hNPCs; hESCs; fibroblasts; A549; GM12878; MM6; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; GSCs
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2; ENST00000472142.1
External Link	RMBase: m6A_site_459663
mod ID: M6ASITE042796		Click to Show/Hide the Full List
mod site	chr2:8683797-8683798:+		[3]
Sequence	AAGGAGGACAAGTTGAATGGACCTTTTTAAAAAGAAAAAAA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; hNPCs; hESCs; fibroblasts; A549; GM12878; MM6; Huh7; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000472142.1; ENST00000396290.2
External Link	RMBase: m6A_site_459664
mod ID: M6ASITE042797		Click to Show/Hide the Full List
mod site	chr2:8683831-8683832:+		[3]
Sequence	AAAAAAAAAATGGAAGGAAAACTAAGAATGATCATCTTCCC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; hNPCs; hESCs; fibroblasts; A549; GM12878; LCLs; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; GSCs
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000396290.2; ENST00000234091.8; ENST00000472142.1
External Link	RMBase: m6A_site_459665
mod ID: M6ASITE042798		Click to Show/Hide the Full List
mod site	chr2:8683865-8683866:+		[9]
Sequence	TCTTCCCAGGGTGTTCTCTTACTTGGACTGTGATATTCGTT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000472142.1; ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459666
mod ID: M6ASITE042799		Click to Show/Hide the Full List
mod site	chr2:8683871-8683872:+		[4]
Sequence	CAGGGTGTTCTCTTACTTGGACTGTGATATTCGTTATTTAT
Motif Score	4.065041667
Cell/Tissue List	HepG2; HEK293T; HeLa; hNPCs; hESCs; fibroblasts; A549; GM12878; LCLs; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000472142.1; ENST00000396290.2
External Link	RMBase: m6A_site_459667
mod ID: M6ASITE042800		Click to Show/Hide the Full List
mod site	chr2:8683899-8683900:+		[4]
Sequence	ATTCGTTATTTATGAAAAAGACTTTTAAATGCCCTTTCTGC
Motif Score	3.319380952
Cell/Tissue List	HepG2; HEK293T; HeLa; hNPCs; hESCs; fibroblasts; A549; GM12878; LCLs; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX; GSCs
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000472142.1; ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459668
mod ID: M6ASITE042801		Click to Show/Hide the Full List
mod site	chr2:8683978-8683979:+		[5]
Sequence	GGAGCGAAAACGTTAAAATCACAAGGAATTGCCCAATCTAA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000396290.2; ENST00000472142.1; ENST00000234091.8
External Link	RMBase: m6A_site_459669
mod ID: M6ASITE042802		Click to Show/Hide the Full List
mod site	chr2:8684003-8684004:+		[4]
Sequence	GAATTGCCCAATCTAAGCAGACTTTGCCTTTTTTCAAAGGT
Motif Score	3.319380952
Cell/Tissue List	HepG2; HEK293T; HeLa; hNPCs; hESCs; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000396290.2; ENST00000472142.1; ENST00000234091.8
External Link	RMBase: m6A_site_459670
mod ID: M6ASITE042803		Click to Show/Hide the Full List
mod site	chr2:8684097-8684098:+		[5]
Sequence	GGTCAGAAATTACCTTTTTGACACAAGCCTACTGAATGCTG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459671
mod ID: M6ASITE042804		Click to Show/Hide the Full List
mod site	chr2:8684107-8684108:+		[9]
Sequence	TACCTTTTTGACACAAGCCTACTGAATGCTGTGTATATATT
Motif Score	2.500660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459672
mod ID: M6ASITE042805		Click to Show/Hide the Full List
mod site	chr2:8684156-8684157:+		[10]
Sequence	AATATATCTATTTGAGTGAAACCTTGTGAACTCTTTAATTA
Motif Score	2.185083333
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459673
mod ID: M6ASITE042806		Click to Show/Hide the Full List
mod site	chr2:8684165-8684166:+		[10]
Sequence	ATTTGAGTGAAACCTTGTGAACTCTTTAATTAGAGTTTTCT
Motif Score	3.373380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459674
mod ID: M6ASITE042807		Click to Show/Hide the Full List
mod site	chr2:8684235-8684236:+		[9]
Sequence	ATTCAAAAGTGTAATGATGTACTTATTCATGCTAAACTTTT
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459675
mod ID: M6ASITE042808		Click to Show/Hide the Full List
mod site	chr2:8684250-8684251:+		[10]
Sequence	GATGTACTTATTCATGCTAAACTTTTTATAAAAGTTTAGTT
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459676
mod ID: M6ASITE042809		Click to Show/Hide the Full List
mod site	chr2:8684275-8684276:+		[10]
Sequence	TTATAAAAGTTTAGTTGTAAACTTAACCCTTTTATACAAAA
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000234091.8; ENST00000396290.2
External Link	RMBase: m6A_site_459677
mod ID: M6ASITE042810		Click to Show/Hide the Full List
mod site	chr2:8684290-8684291:+		[9]
Sequence	TGTAAACTTAACCCTTTTATACAAAATAAATCAAGTGTGTT
Motif Score	2.110482143
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459678
mod ID: M6ASITE042811		Click to Show/Hide the Full List
mod site	chr2:8684396-8684397:+		[5]
Sequence	ATAACTGAACCCAAATAAATACAAGTTCAAATTTATGTAGA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000396290.2; ENST00000234091.8
External Link	RMBase: m6A_site_459679

Ref 1	2011 Pipeline of Quark Pharm.
Ref 2	KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA. Onco Targets Ther. 2019 May 7;12:3421-3428. doi: 10.2147/OTT.S180954. eCollection 2019.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 7	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 10	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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