m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00127)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR25
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | Cigarette smoke-induced microRNA 25 (MIR25) excessive maturation via m6A modification promotes the development and progression of pancreatic cancer. This modification is catalyzed by overexpressed methyltransferase-like 3 (METTL3) due to hypomethylation of the METTL3 promoter also caused by CSC. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Pancreatic cancer | ICD-11: 2C10 | ||
| Pathway Response | PI3K-Akt signaling pathway | hsa04151 | ||
| Cell Process | Cell proliferation | |||
| In-vitro Model | HEK293T | Normal | Homo sapiens | CVCL_0063 |
| BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens | CVCL_0186 | |
| HPDE6c7 | Normal | Homo sapiens | CVCL_0P38 | |
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens | CVCL_0480 | |
| SW1990 | Pancreatic adenocarcinoma | Homo sapiens | CVCL_1723 | |
| In-vivo Model | Mice (five in each group) were injected subcutaneously with 0.1 ml of cell suspension containing 2 × 106 cells in the back flank. | |||
Pancreatic cancer [ICD-11: 2C10]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | Cigarette smoke-induced microRNA 25 (MIR25) excessive maturation via m6A modification promotes the development and progression of pancreatic cancer. This modification is catalyzed by overexpressed methyltransferase-like 3 (METTL3) due to hypomethylation of the METTL3 promoter also caused by CSC. | |||
| Responsed Disease | Pancreatic cancer [ICD-11: 2C10] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | PI3K-Akt signaling pathway | hsa04151 | ||
| Cell Process | Cell proliferation | |||
| In-vitro Model | HEK293T | Normal | Homo sapiens | CVCL_0063 |
| BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens | CVCL_0186 | |
| HPDE6c7 | Normal | Homo sapiens | CVCL_0P38 | |
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens | CVCL_0480 | |
| SW1990 | Pancreatic adenocarcinoma | Homo sapiens | CVCL_1723 | |
| In-vivo Model | Mice (five in each group) were injected subcutaneously with 0.1 ml of cell suspension containing 2 × 106 cells in the back flank. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00639 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Zinc finger protein SNAI1 (SNAI1) | |
| Crosstalk relationship | m6A → m5C | |
DNA modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT02030 | ||
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |
| Crosstalk ID: M6ACROT02031 | ||
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |
m6A Regulator: NF-kappa-B-activating protein (NKAP)
| In total 2 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT02032 | ||
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |
| Crosstalk ID: M6ACROT02033 | ||
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Pancreatic cancer | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05379 | ||
| Epigenetic Regulator | MicroRNA 25 (MIR25) | |
| Regulated Target | PHLPP-like (PHLPP2) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Pancreatic cancer | |