m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00121)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR335
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
| Representative RNA-seq result indicating the expression of this target gene regulated by METTL3 | ||
| Cell Line | Mouse testis | Mus musculus |
|
Treatment: Mettl3 knockout mouse testis
Control: Mouse testis
|
GSE99771 | |
| Regulation |
  |
logFC: 5.81E+00 p-value: 4.09E-06 |
| More Results | Click to View More RNA-seq Results | |
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL3-mediated m6A methylation increases the maturation of microRNA 335 (MIR335), which promotes SG formation and reduces the apoptosis level of injury neurons and cells, and provides a potential therapeutic strategy for acute ischemic stroke. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Acute ischemic stroke | ICD-11: 8B11 | ||
| Cell Process | RNA maturation | |||
| Cell apoptosis | ||||
| In-vitro Model | PC-12 | Lung papillary adenocarcinoma | Homo sapiens | CVCL_S979 |
| In-vivo Model | After a median incision on the neck, the left common carotid artery (CCA), internal carotid artery (ICA), and external carotid artery (ECA) were isolated. The left CCA and the ECA were ligated. | |||
Acute ischemic stroke [ICD-11: 8B11]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL3-mediated m6A methylation increases the maturation of microRNA 335 (MIR335), which promotes SG formation and reduces the apoptosis level of injury neurons and cells, and provides a potential therapeutic strategy for acute ischemic stroke. | |||
| Responsed Disease | Acute ischemic stroke [ICD-11: 8B11] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | RNA maturation | |||
| Cell apoptosis | ||||
| In-vitro Model | PC-12 | Lung papillary adenocarcinoma | Homo sapiens | CVCL_S979 |
| In-vivo Model | After a median incision on the neck, the left common carotid artery (CCA), internal carotid artery (ICA), and external carotid artery (ECA) were isolated. The left CCA and the ECA were ligated. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05434 | ||
| Epigenetic Regulator | MicroRNA 335 (MIR335) | |
| Regulated Target | ZFP36 ring finger protein like 1 (ZFP36L1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Acute ischemic stroke | |