m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00118)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
MIR375
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 14 (METTL14) [WRITER]
| In total 2 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | METTL14 suppressed Colorectal cancer cell growth, migration, and invasion via the microRNA 375 (MIR375)/YAP1 and miR-375/SP1 pathways. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
| Pathway Response | Hippo signaling pathway | hsa04390 | ||
| Cell Process | Cell growth and metastasis | |||
| In-vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens | CVCL_0248 |
| FHC | Normal | Homo sapiens | CVCL_3688 | |
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
| HT29 | Colon cancer | Mus musculus | CVCL_A8EZ | |
| SW480 | Colon adenocarcinoma | Homo sapiens | CVCL_0546 | |
| SW620 | Colon adenocarcinoma | Homo sapiens | CVCL_0547 | |
| In-vivo Model | Six-week-old BALB/c nude mice were purchased from the College of Veterinary Medicine, Yang Zhou University. For the xenografted tumor model, 1 × 107 HCT116 cells in 0.2 mL PBS were subcutaneously injected into BALB/c nude mice, which were randomly divided into four groups (six mice per group). The volume of the tumors was calculated with the following equation: V = 0.5 × (length × width2). For metastasis experiments, 2 × 106 cells in 0.2 mL PBS were injected into the tail vein of nude mice, which were randomly divided into four groups (six mice per group). | |||
| Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene | [3] | |||
| Response Summary | Mettl14-mediated m6A modification inhibited RASD1 and induced the apoptosis of spinal cord neurons in SCI by promoting the transformation of pri-miR-375 to mature microRNA 375 (MIR375). | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Injuries of spine or trunk | ICD-11: ND51 | ||
| Pathway Response | mTOR signaling pathway | hsa04150 | ||
| In-vitro Model | C8-D1A | Normal | Mus musculus | CVCL_6379 |
| C8-B4 | Normal | Mus musculus | CVCL_6378 | |
| In-vivo Model | An incision was made in the skin along the medial dorsal line to the aponeurotic and muscular planes, and the posterior vertebral arches were exposed from T8 to T12. Under the dissection stereomicroscope, 3-mm-long laminectomy was performed on the caudal end of T10 vertebra and the rostral end of T11 vertebra. The Infinite Horizons impactor (Infinite Horizons, L.L.C., Lexington, KY, USA) was adopted to produce the contusion SCI using a force of 60 kdyn/cm2. The SCI model rats were established and randomly assigned to SCI model group, ant-NC (negative control, SCI rats treated with lentiviral (lv)-shRNA NC of Mettl14) group and ant-Mettl14 group (SCI rats treated with lv-shRNA of Mettl14). Rats were subjected to laminectomy and then treated with lv-shRNA Mettl14/lv-shRNA-NC (50 ul/day, 100 nmoL/mL; RiboBio, Guangzhou, China) via an intrathecal injection through lumbar puncture for 3 days (0, 1, and 2 days) after 15 min of SCI modelling. In addition, the unmodeled rats were set as sham group. | |||
Colorectal cancer [ICD-11: 2B91]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | METTL14 suppressed Colorectal cancer cell growth, migration, and invasion via the microRNA 375 (MIR375)/YAP1 and miR-375/SP1 pathways. | |||
| Responsed Disease | Colorectal cancer [ICD-11: 2B91] | |||
| Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Hippo signaling pathway | hsa04390 | ||
| Cell Process | Cell growth and metastasis | |||
| In-vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens | CVCL_0248 |
| FHC | Normal | Homo sapiens | CVCL_3688 | |
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | |
| HT29 | Colon cancer | Mus musculus | CVCL_A8EZ | |
| SW480 | Colon adenocarcinoma | Homo sapiens | CVCL_0546 | |
| SW620 | Colon adenocarcinoma | Homo sapiens | CVCL_0547 | |
| In-vivo Model | Six-week-old BALB/c nude mice were purchased from the College of Veterinary Medicine, Yang Zhou University. For the xenografted tumor model, 1 × 107 HCT116 cells in 0.2 mL PBS were subcutaneously injected into BALB/c nude mice, which were randomly divided into four groups (six mice per group). The volume of the tumors was calculated with the following equation: V = 0.5 × (length × width2). For metastasis experiments, 2 × 106 cells in 0.2 mL PBS were injected into the tail vein of nude mice, which were randomly divided into four groups (six mice per group). | |||
Injuries of spine or trunk [ICD-11: ND51]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [3] | |||
| Response Summary | Mettl14-mediated m6A modification inhibited RASD1 and induced the apoptosis of spinal cord neurons in SCI by promoting the transformation of pri-miR-375 to mature microRNA 375 (MIR375). | |||
| Responsed Disease | Injuries of spine or trunk [ICD-11: ND51] | |||
| Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | mTOR signaling pathway | hsa04150 | ||
| In-vitro Model | C8-D1A | Normal | Mus musculus | CVCL_6379 |
| C8-B4 | Normal | Mus musculus | CVCL_6378 | |
| In-vivo Model | An incision was made in the skin along the medial dorsal line to the aponeurotic and muscular planes, and the posterior vertebral arches were exposed from T8 to T12. Under the dissection stereomicroscope, 3-mm-long laminectomy was performed on the caudal end of T10 vertebra and the rostral end of T11 vertebra. The Infinite Horizons impactor (Infinite Horizons, L.L.C., Lexington, KY, USA) was adopted to produce the contusion SCI using a force of 60 kdyn/cm2. The SCI model rats were established and randomly assigned to SCI model group, ant-NC (negative control, SCI rats treated with lentiviral (lv)-shRNA NC of Mettl14) group and ant-Mettl14 group (SCI rats treated with lv-shRNA of Mettl14). Rats were subjected to laminectomy and then treated with lv-shRNA Mettl14/lv-shRNA-NC (50 ul/day, 100 nmoL/mL; RiboBio, Guangzhou, China) via an intrathecal injection through lumbar puncture for 3 days (0, 1, and 2 days) after 15 min of SCI modelling. In addition, the unmodeled rats were set as sham group. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
RNA modification
m6A Regulator: Methyltransferase-like 14 (METTL14)
| In total 6 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT00657 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00658 | ||
| Epigenetic Regulator | H/ACA ribonucleoprotein complex subunit DKC1 (DKC1) | |
| Regulated Target | Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) | |
| Crosstalk relationship | m6A → Pseudouridine | |
| Crosstalk ID: M6ACROT00659 | ||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | |
| Regulated Target | Transcriptional coactivator YAP1 (YAP1) | |
| Crosstalk relationship | m6A → m5C | |
| Crosstalk ID: M6ACROT00660 | ||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | |
| Regulated Target | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | |
| Crosstalk relationship | m6A → m6Am | |
| Crosstalk ID: M6ACROT00661 | ||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | |
| Regulated Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Crosstalk relationship | m6Am → m6A | |
| Crosstalk ID: M6ACROT00662 | ||
| Epigenetic Regulator | Methyltransferase-like protein 1 (METTL1) | |
| Regulated Target | High mobility group protein HMGI-C (HMGA2) | |
| Crosstalk relationship | m6A → m7G | |
DNA modification
m6A Regulator: Methyltransferase-like 14 (METTL14)
| In total 3 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT02101 | ||
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT02102 | ||
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 3B (DNMT3B) | |
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT02103 | ||
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Breast cancer | |
Histone modification
m6A Regulator: Methyltransferase-like 14 (METTL14)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03276 | ||
| Epigenetic Regulator | Lysine-specific demethylase 5C (KDM5C) | |
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Colorectal cancer | |
Non-coding RNA
m6A Regulator: Methyltransferase-like 14 (METTL14)
| In total 3 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05410 | ||
| Epigenetic Regulator | MicroRNA 375 (MIR375) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Colorectal cancer | |
| Crosstalk ID: M6ACROT05606 | ||
| Epigenetic Regulator | MicroRNA 375 (MIR375) | |
| Regulated Target | Dexamethasone-induced Ras-related protein 1 (RASD1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Injuries of spine or trunk | |
| Crosstalk ID: M6ACROT05931 | ||
| Epigenetic Regulator | MicroRNA 375 (MIR375) | |
| Regulated Target | Transcription factor SOX-12 (SOX12) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Breast cancer | |
References