m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00662				[1], [2], [3]
m⁶A modification MIR375 MIR375 METTL14 Methylation : m⁶A sites Indirect Enhancement RNA modification HMGA2 HMGA2 METTL1 Methylation : modification sites
m6A Regulator	Methyltransferase-like 14 (METTL14)			WRITER	Regulator Info
m6A Target	microRNA 375 (MIR375)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N7-methylguanosine (m7G)
Epigenetic Regulator	Methyltransferase-like protein 1 (METTL1)			WRITER	View Details
Regulated Target	High mobility group protein HMGI-C (HMGA2)				View Details
Crosstalk Relationship	m6A → m7G			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL14 interacts with microRNA 375 (MIR375), increasing its m6A level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by METTL1-mediated m7G modification.
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens		CVCL_0023
	Caco-2	Colon adenocarcinoma	Homo sapiens		CVCL_0025
	HCT 8	Colon adenocarcinoma	Homo sapiens		CVCL_2478
	HCT 116	Colon carcinoma	Homo sapiens		CVCL_0291

References

Ref 1	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.
Ref 2	RETRACTED: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing. Mol Ther. 2020 Feb 5;28(2):599-612. doi: 10.1016/j.ymthe.2019.11.016. Epub 2019 Nov 20.
Ref 3	Circular RNA circZFR Promotes Hepatocellular Carcinoma Progression by Regulating miR-375/HMGA2 Axis. Dig Dis Sci. 2021 Dec;66(12):4361-4373. doi: 10.1007/s10620-020-06805-2. Epub 2021 Jan 12.