Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00168)

Target Name	High mobility group protein HMGI-C (HMGA2)
Synonyms	High mobility group AT-hook protein 2; HMGIC Click to Show/Hide
Gene Name	HMGA2
Sequence	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED Click to Show/Hide
Family	HMGA family
Function	Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner. Click to Show/Hide
Gene ID	8091
HGNC ID	HGNC:5009
Ensembl Gene ID	ENSG00000149948
KEGG ID	hsa:8091
Chromosomal Location	12q14.3

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00168)

High mobility group protein HMGI-C (HMGA2)

5-methylcytidine (m5C)

In total 5 m6A sequence/site(s) in this target gene
mod ID: M5CSITE000072		Click to Show/Hide the Full List
mod site	chr12:65840305-65840306:+
Sequence	GGCAGGGTAGAGCAGAAAGTCTTGTCTCTGCTCCATGATGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000393578.7; ENST00000537429.5; ENST00000403681.6; ENST00000539662.1; ENST00000541363.5; ENST00000425208.6; ENST00000536545.5; ENST00000354636.7; ENST00000393577.7; ENST00000537275.5
External Link	RMBase: m5C_site_10596
mod ID: M5CSITE000073		Click to Show/Hide the Full List
mod site	chr12:65881887-65881888:+
Sequence	AGAGGTGGCCCGAGAGAGCCCCGGTAGGTCCCGGAGTATGT
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000425208.6; ENST00000393577.7; ENST00000536545.5; ENST00000354636.7; ENST00000541363.5; ENST00000537429.5; ENST00000539662.1; ENST00000403681.6
External Link	RMBase: m5C_site_10597
mod ID: M5CSITE000074		Click to Show/Hide the Full List
mod site	chr12:65882120-65882121:+
Sequence	GGCTGTACTGACAAAAGCAACCTTAGTCAATGACAGAGCTG
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000393577.7; ENST00000541363.5; ENST00000403681.6; ENST00000536545.5; ENST00000354636.7; ENST00000425208.6; ENST00000539662.1
External Link	RMBase: m5C_site_10598
mod ID: M5CSITE000075		Click to Show/Hide the Full List
mod site	chr12:65964524-65964525:+
Sequence	TGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m5C_site_10599
mod ID: M5CSITE000076		Click to Show/Hide the Full List
mod site	chr12:65965837-65965838:+
Sequence	TCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAA
Cell/Tissue List	T24
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m5C_site_10600

N6-methyladenosine (m6A)

In total 63 m6A sequence/site(s) in this target gene
mod ID: M6ASITE013755		Click to Show/Hide the Full List
mod site	chr12:65824478-65824479:+		[1]
Sequence	ACTTGAATCTTGGGGCAGGAACTCAGAAAACTTCCAGCCCG
Motif Score	3.373380952
Cell/Tissue List	HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; A549; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000537275.5; ENST00000403681.6; ENST00000537429.5; ENST00000393578.7; ENST00000536545.5; ENST00000354636.7; ENST00000425208.6
External Link	RMBase: m6A_site_197400
mod ID: M6ASITE013756		Click to Show/Hide the Full List
mod site	chr12:65824487-65824488:+		[1]
Sequence	TTGGGGCAGGAACTCAGAAAACTTCCAGCCCGGGCAGCGCG
Motif Score	2.627720238
Cell/Tissue List	HepG2; HEK293T; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; A549; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000536545.5; ENST00000403681.6; ENST00000537275.5; ENST00000393578.7; ENST00000537429.5; ENST00000354636.7; ENST00000425208.6
External Link	RMBase: m6A_site_197401
mod ID: M6ASITE013757		Click to Show/Hide the Full List
mod site	chr12:65824521-65824522:+		[2]
Sequence	CAGCGCGCGCTTGGTGCAAGACTCAGGAGCTAGCAGCCCGT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293T; U2OS; H1B; hESCs; fibroblasts; A549; H1299; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000536545.5; ENST00000537275.5; ENST00000425208.6; ENST00000403681.6; ENST00000354636.7; ENST00000537429.5; ENST00000393578.7
External Link	RMBase: m6A_site_197402
mod ID: M6ASITE013758		Click to Show/Hide the Full List
mod site	chr12:65824823-65824824:+		[2]
Sequence	CCCGCCTAACATTTCAAGGGACACAATTCACTCCAAGTCTC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; U2OS; H1A; fibroblasts; Huh7; GSC-11; iSLK; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000403681.6; ENST00000354636.7; ENST00000545998.1; ENST00000536545.5; ENST00000537275.5; ENST00000393578.7; ENST00000425208.6; ENST00000537429.5
External Link	RMBase: m6A_site_197403
mod ID: M6ASITE013759		Click to Show/Hide the Full List
mod site	chr12:65825320-65825321:+		[2]
Sequence	CCGTCCACTTCAGCCCAGGGACAACCTGCCGCCCCAGCGCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; U2OS; H1299; GSC-11; iSLK; MSC; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000545998.1; ENST00000537429.5; ENST00000393577.7; ENST00000537275.5; ENST00000425208.6; ENST00000393578.7; ENST00000541363.5; ENST00000536545.5; ENST00000354636.7; ENST00000403681.6
External Link	RMBase: m6A_site_197404
mod ID: M6ASITE013760		Click to Show/Hide the Full List
mod site	chr12:65828002-65828003:+		[2]
Sequence	TTTTTCCCTCACAATTAGGAACCAACCGGTGAGCCCTCTCC
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; U2OS; hNPCs; fibroblasts; H1299; GSC-11; HEK293T; iSLK; MSC; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000425208.6; ENST00000354636.7; ENST00000545998.1; ENST00000541363.5; ENST00000403681.6; ENST00000537275.5; ENST00000539662.1; ENST00000537429.5; ENST00000536545.5; ENST00000393577.7; ENST00000393578.7
External Link	RMBase: m6A_site_197406
mod ID: M6ASITE013761		Click to Show/Hide the Full List
mod site	chr12:65828029-65828030:+		[2]
Sequence	GGTGAGCCCTCTCCTAAGAGACCCAGGGGAAGACCCAAAGG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; U2OS; hNPCs; fibroblasts; H1299; Huh7; GSC-11; HEK293T; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000536545.5; ENST00000537275.5; ENST00000545998.1; ENST00000541363.5; ENST00000403681.6; ENST00000393577.7; ENST00000539662.1; ENST00000393578.7; ENST00000537429.5; ENST00000354636.7; ENST00000425208.6
External Link	RMBase: m6A_site_197407
mod ID: M6ASITE013762		Click to Show/Hide the Full List
mod site	chr12:65828041-65828042:+		[2]
Sequence	CCTAAGAGACCCAGGGGAAGACCCAAAGGCAGCAAAAACAA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; U2OS; hNPCs; fibroblasts; H1299; Huh7; GSC-11; HEK293T; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000403681.6; ENST00000541363.5; ENST00000536545.5; ENST00000425208.6; ENST00000537429.5; ENST00000539662.1; ENST00000354636.7; ENST00000537275.5; ENST00000393578.7; ENST00000393577.7; ENST00000545998.1
External Link	RMBase: m6A_site_197408
mod ID: M6ASITE013763		Click to Show/Hide the Full List
mod site	chr12:65828058-65828059:+		[2]
Sequence	AAGACCCAAAGGCAGCAAAAACAAGAGTCCCTCTAAAGCAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; hESC-HEK293T; U2OS; hNPCs; fibroblasts; H1299; Huh7; GSC-11; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000541363.5; ENST00000536545.5; ENST00000393578.7; ENST00000537429.5; ENST00000425208.6; ENST00000354636.7; ENST00000403681.6; ENST00000539662.1; ENST00000537275.5; ENST00000545998.1; ENST00000393577.7
External Link	RMBase: m6A_site_197409
mod ID: M6ASITE013764		Click to Show/Hide the Full List
mod site	chr12:65828205-65828206:+		[2]
Sequence	TCCCAACTGGGTAACACAAGACTCATTTCTTACATTTAACA
Motif Score	3.319380952
Cell/Tissue List	HeLa; U2OS; H1299
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000537429.5; ENST00000545998.1; ENST00000536545.5; ENST00000537275.5; ENST00000393577.7; ENST00000541363.5; ENST00000403681.6; ENST00000354636.7; ENST00000539662.1; ENST00000393578.7; ENST00000425208.6
External Link	RMBase: m6A_site_197410
mod ID: M6ASITE013765		Click to Show/Hide the Full List
mod site	chr12:65830919-65830920:+		[3]
Sequence	CTACTTAATATTCCATTAAAACTAATTACTATGCATGACCA
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000615897.1; ENST00000537275.5; ENST00000393577.7; ENST00000537429.5; ENST00000536545.5; ENST00000425208.6; ENST00000354636.7; ENST00000393578.7; ENST00000403681.6; ENST00000539662.1; ENST00000541363.5
External Link	RMBase: m6A_site_197411
mod ID: M6ASITE013766		Click to Show/Hide the Full List
mod site	chr12:65830969-65830970:+		[3]
Sequence	GATTCTAGTCATTCCTCAGAACTCCAATCTGAGTGCTCAAA
Motif Score	3.373380952
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000393577.7; ENST00000537429.5; ENST00000393578.7; ENST00000539662.1; ENST00000354636.7; ENST00000403681.6; ENST00000425208.6; ENST00000536545.5; ENST00000541363.5; ENST00000615897.1; ENST00000537275.5
External Link	RMBase: m6A_site_197412
mod ID: M6ASITE013767		Click to Show/Hide the Full List
mod site	chr12:65838556-65838557:+		[4]
Sequence	GAAAAACGGCCAAGAGGCAGACCTAGGAAATGGGTGAGTAA
Motif Score	2.876744048
Cell/Tissue List	H1A; hNPCs; H1299; Huh7; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000354636.7; ENST00000403681.6; ENST00000393578.7; ENST00000541363.5; ENST00000537429.5; ENST00000536545.5; ENST00000537275.5; ENST00000539662.1; ENST00000425208.6; ENST00000393577.7
External Link	RMBase: m6A_site_197413
mod ID: M6ASITE013768		Click to Show/Hide the Full List
mod site	chr12:65867784-65867785:+		[5]
Sequence	ACATAAAGCTTGTCATCTGAACAGGACTATAAGCATCTCGA
Motif Score	2.951386905
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000403681.6; ENST00000393577.7; ENST00000537429.5; ENST00000541363.5; ENST00000354636.7; ENST00000536545.5; ENST00000425208.6; ENST00000539662.1
External Link	RMBase: m6A_site_197439
mod ID: M6ASITE013769		Click to Show/Hide the Full List
mod site	chr12:65867789-65867790:+		[5]
Sequence	AAGCTTGTCATCTGAACAGGACTATAAGCATCTCGAGGGTA
Motif Score	4.065041667
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000403681.6; ENST00000541363.5; ENST00000393577.7; ENST00000354636.7; ENST00000425208.6; ENST00000536545.5; ENST00000537429.5; ENST00000539662.1
External Link	RMBase: m6A_site_197440
mod ID: M6ASITE013770		Click to Show/Hide the Full List
mod site	chr12:65881793-65881794:+		[6]
Sequence	GGAAGCCTGCTGATCCCGGAACTGGCCTTGCGCGCAAGTGG
Motif Score	3.373380952
Cell/Tissue List	fibroblasts; iSLK; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000425208.6; ENST00000393577.7; ENST00000537429.5; ENST00000354636.7; ENST00000539662.1; ENST00000536545.5; ENST00000403681.6; ENST00000541363.5
External Link	RMBase: m6A_site_197446
mod ID: M6ASITE013771		Click to Show/Hide the Full List
mod site	chr12:65881825-65881826:+		[6]
Sequence	CGCAAGTGGTGGGATGACAGACACATTCCCTTCCTTGAACT
Motif Score	2.897386905
Cell/Tissue List	fibroblasts; GSC-11; iSLK; TIME; TREX; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000539662.1; ENST00000541363.5; ENST00000393577.7; ENST00000536545.5; ENST00000537429.5; ENST00000354636.7; ENST00000425208.6; ENST00000403681.6
External Link	RMBase: m6A_site_197447
mod ID: M6ASITE013772		Click to Show/Hide the Full List
mod site	chr12:65881843-65881844:+		[6]
Sequence	AGACACATTCCCTTCCTTGAACTGCACTCTTTTCCCTTGCA
Motif Score	3.373380952
Cell/Tissue List	fibroblasts; peripheral-blood; GSC-11; iSLK; TIME; TREX; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000537429.5; ENST00000354636.7; ENST00000393577.7; ENST00000403681.6; ENST00000536545.5; ENST00000425208.6; ENST00000541363.5; ENST00000539662.1
External Link	RMBase: m6A_site_197448
mod ID: M6ASITE013773		Click to Show/Hide the Full List
mod site	chr12:65951384-65951385:+		[7]
Sequence	TTTTCTTTTCCTCCTTAGCCACAACAAGTTGTTCAGAAGAA
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000393577.7; ENST00000541363.5; ENST00000403681.6; ENST00000539662.1
External Link	RMBase: m6A_site_197459
mod ID: M6ASITE013774		Click to Show/Hide the Full List
mod site	chr12:65951387-65951388:+		[7]
Sequence	TCTTTTCCTCCTTAGCCACAACAAGTTGTTCAGAAGAAGCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000541363.5; ENST00000539662.1; ENST00000393577.7; ENST00000403681.6
External Link	RMBase: m6A_site_197460
mod ID: M6ASITE013775		Click to Show/Hide the Full List
mod site	chr12:65963250-65963251:+		[8]
Sequence	TTTGTGTGTTCCAGGAGGAAACTGAAGAGACATCCTCACAA
Motif Score	2.627720238
Cell/Tissue List	HEK293T; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000539662.1; ENST00000403681.6
External Link	RMBase: m6A_site_197461
mod ID: M6ASITE013776		Click to Show/Hide the Full List
mod site	chr12:65963259-65963260:+		[7]
Sequence	TCCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCC
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; HEC-1-A; NB4
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000539662.1; ENST00000403681.6
External Link	RMBase: m6A_site_197462
mod ID: M6ASITE013777		Click to Show/Hide the Full List
mod site	chr12:65963267-65963268:+		[7]
Sequence	GAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6; ENST00000539662.1
External Link	RMBase: m6A_site_197463
mod ID: M6ASITE013778		Click to Show/Hide the Full List
mod site	chr12:65963287-65963288:+		[8]
Sequence	ACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; HEC-1-A; NB4
Seq Type List	m6A-seq
Transcript ID List	ENST00000403681.6; ENST00000539662.1
External Link	RMBase: m6A_site_197464
mod ID: M6ASITE013779		Click to Show/Hide the Full List
mod site	chr12:65963349-65963350:+		[7]
Sequence	GGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATT
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; Huh7; HEC-1-A; NB4
Seq Type List	MAZTER-seq; MeRIP-seq; m6A-seq
Transcript ID List	ENST00000539662.1; ENST00000403681.6
External Link	RMBase: m6A_site_197465
mod ID: M6ASITE013780		Click to Show/Hide the Full List
mod site	chr12:65963452-65963453:+		[7]
Sequence	GGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197466
mod ID: M6ASITE013781		Click to Show/Hide the Full List
mod site	chr12:65963469-65963470:+		[3]
Sequence	ATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTT
Motif Score	4.065041667
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197467
mod ID: M6ASITE013782		Click to Show/Hide the Full List
mod site	chr12:65963523-65963524:+		[3]
Sequence	AGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGAC
Motif Score	2.627720238
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197468
mod ID: M6ASITE013783		Click to Show/Hide the Full List
mod site	chr12:65963533-65963534:+		[3]
Sequence	TTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAAC
Motif Score	2.20572619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197469
mod ID: M6ASITE013784		Click to Show/Hide the Full List
mod site	chr12:65963552-65963553:+		[7]
Sequence	AACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197470
mod ID: M6ASITE013785		Click to Show/Hide the Full List
mod site	chr12:65963678-65963679:+		[7]
Sequence	AATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197471
mod ID: M6ASITE013786		Click to Show/Hide the Full List
mod site	chr12:65963692-65963693:+		[7]
Sequence	ATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197472
mod ID: M6ASITE013787		Click to Show/Hide the Full List
mod site	chr12:65963737-65963738:+		[7]
Sequence	TAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATA
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197473
mod ID: M6ASITE013788		Click to Show/Hide the Full List
mod site	chr12:65963746-65963747:+		[7]
Sequence	CGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197474
mod ID: M6ASITE013789		Click to Show/Hide the Full List
mod site	chr12:65963798-65963799:+		[7]
Sequence	TAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGA
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197475
mod ID: M6ASITE013790		Click to Show/Hide the Full List
mod site	chr12:65963813-65963814:+		[9]
Sequence	TTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTT
Motif Score	4.065041667
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197476
mod ID: M6ASITE013791		Click to Show/Hide the Full List
mod site	chr12:65963851-65963852:+		[7]
Sequence	TTTTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTA
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197477
mod ID: M6ASITE013792		Click to Show/Hide the Full List
mod site	chr12:65963857-65963858:+		[9]
Sequence	GTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197478
mod ID: M6ASITE013793		Click to Show/Hide the Full List
mod site	chr12:65963924-65963925:+		[7]
Sequence	TGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGT
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197479
mod ID: M6ASITE013794		Click to Show/Hide the Full List
mod site	chr12:65963972-65963973:+		[7]
Sequence	TCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197480
mod ID: M6ASITE013795		Click to Show/Hide the Full List
mod site	chr12:65964271-65964272:+		[7]
Sequence	ATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197481
mod ID: M6ASITE013796		Click to Show/Hide the Full List
mod site	chr12:65964442-65964443:+		[7]
Sequence	ACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGG
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197482
mod ID: M6ASITE013797		Click to Show/Hide the Full List
mod site	chr12:65964562-65964563:+		[7]
Sequence	CAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGT
Motif Score	2.07285119
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197483
mod ID: M6ASITE013798		Click to Show/Hide the Full List
mod site	chr12:65964667-65964668:+		[7]
Sequence	TCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197484
mod ID: M6ASITE013799		Click to Show/Hide the Full List
mod site	chr12:65964716-65964717:+		[9]
Sequence	CCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTT
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197485
mod ID: M6ASITE013800		Click to Show/Hide the Full List
mod site	chr12:65964789-65964790:+		[7]
Sequence	AGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTT
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197486
mod ID: M6ASITE013801		Click to Show/Hide the Full List
mod site	chr12:65964853-65964854:+		[7]
Sequence	AAGGATAATTTTCCTCAATCACACTACACATCACACAAGAT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197487
mod ID: M6ASITE013802		Click to Show/Hide the Full List
mod site	chr12:65964985-65964986:+		[9]
Sequence	CCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCA
Motif Score	3.373380952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197488
mod ID: M6ASITE013803		Click to Show/Hide the Full List
mod site	chr12:65965058-65965059:+		[9]
Sequence	TGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATT
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197489
mod ID: M6ASITE013804		Click to Show/Hide the Full List
mod site	chr12:65965074-65965075:+		[9]
Sequence	CAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACAC
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197490
mod ID: M6ASITE013805		Click to Show/Hide the Full List
mod site	chr12:65965158-65965159:+		[9]
Sequence	AAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAG
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197491
mod ID: M6ASITE013806		Click to Show/Hide the Full List
mod site	chr12:65965184-65965185:+		[7]
Sequence	AGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197492
mod ID: M6ASITE013807		Click to Show/Hide the Full List
mod site	chr12:65965257-65965258:+		[9]
Sequence	TGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTT
Motif Score	2.859755952
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197493
mod ID: M6ASITE013808		Click to Show/Hide the Full List
mod site	chr12:65965374-65965375:+		[9]
Sequence	CTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATC
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197494
mod ID: M6ASITE013809		Click to Show/Hide the Full List
mod site	chr12:65965382-65965383:+		[7]
Sequence	GTGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197495
mod ID: M6ASITE013810		Click to Show/Hide the Full List
mod site	chr12:65965516-65965517:+		[7]
Sequence	GGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197496
mod ID: M6ASITE013811		Click to Show/Hide the Full List
mod site	chr12:65965591-65965592:+		[7]
Sequence	ATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGT
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197497
mod ID: M6ASITE013812		Click to Show/Hide the Full List
mod site	chr12:65965733-65965734:+		[7]
Sequence	CAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197498
mod ID: M6ASITE013813		Click to Show/Hide the Full List
mod site	chr12:65965795-65965796:+		[9]
Sequence	TTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTAC
Motif Score	2.856142857
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197499
mod ID: M6ASITE013814		Click to Show/Hide the Full List
mod site	chr12:65965885-65965886:+		[7]
Sequence	TGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATA
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197500
mod ID: M6ASITE013815		Click to Show/Hide the Full List
mod site	chr12:65965970-65965971:+		[7]
Sequence	TGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAAC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197501
mod ID: M6ASITE013816		Click to Show/Hide the Full List
mod site	chr12:65966134-65966135:+		[9]
Sequence	GAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTT
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197502
mod ID: M6ASITE013817		Click to Show/Hide the Full List
mod site	chr12:65966194-65966195:+		[9]
Sequence	ATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCT
Motif Score	2.830589286
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000403681.6
External Link	RMBase: m6A_site_197503

Pseudouridine (Pseudo)

In total 1 m6A sequence/site(s) in this target gene
mod ID: PSESITE000022		Click to Show/Hide the Full List
mod site	chr12:65964467-65964468:+		[10]
Sequence	AGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACC
Transcript ID List	ENST00000403681.6
External Link	RMBase: Pseudo_site_1170

Ref 1	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 2	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 3	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 4	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 5	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 6	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 7	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 8	Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 9;20(5):666-673. doi: 10.1016/j.chom.2016.10.002. Epub 2016 Oct 20.
Ref 9	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 10	Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11(8):592-7. doi: 10.1038/nchembio.1836. Epub 2015 Jun 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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