m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00659
|
[1], [2], [3] | |||
.png)
.png)
 : m6A sites
Indirect
Enhancement
RNA modification
YAP1
YAP1
YBX1
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | microRNA 375 (MIR375) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> 5-methylcytidine (m5C) | ||||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | READER | View Details | ||
| Regulated Target | Transcriptional coactivator YAP1 (YAP1) | View Details | |||
| Crosstalk Relationship | m6A → m5C | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | METTL14 interacts with microRNA 375 (MIR375), reading its m6A level and promoting its physical interaction with Transcriptional coactivator YAP1 (YAP1), which was regulated by YBX1-mediated m5C modification. | ||||
In-vitro Model |
MDA-MB-231 | Breast adenocarcinoma | Homo sapiens | CVCL_0062 | |
| MCF-7 | Invasive breast carcinoma | Homo sapiens | CVCL_0031 | ||
| HCT 8 | Colon adenocarcinoma | Homo sapiens | CVCL_2478 | ||
| HCT 116 | Colon carcinoma | Homo sapiens | CVCL_0291 | ||
References