m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00068)
Target Name hsa_circ_0029589 (Circ_CHFR)
Gene Name Circ_CHFR
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_CHFR can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary The relative RNA expression level of hsa_circ_0029589 in macrophages was decreased, whereas the N6-methyladenosine (m6A) level of hsa_circ_0029589 and the expression of m6A methyltransferase METTL3 were validated to be significantly elevated in macrophages in patients with acute coronary syndrome.
Target Regulation Down regulation
Responsed Disease Acute coronary syndrome ICD-11: BA4Z
 Disease Info 
Cell Process Macrophage pyroptosis
In-vitro Model CD14 + cells (CD14+ cells from human peripheral blood)
Acute coronary syndrome [ICD-11: BA4Z]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary The relative RNA expression level of hsa_circ_0029589 in macrophages was decreased, whereas the N6-methyladenosine (m6A) level of hsa_circ_0029589 and the expression of m6A methyltransferase METTL3 were validated to be significantly elevated in macrophages in patients with acute coronary syndrome.
Responsed Disease Acute coronary syndrome [ICD-11: BA4Z]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Cell Process Macrophage pyroptosis
In-vitro Model CD14 + cells (CD14+ cells from human peripheral blood)
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Non-coding RNA
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05436
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0029589 (Circ_CHFR)
Crosstalk relationship m6A → ncRNA
Disease Acute coronary syndrome
 Disease Info 
References
Ref 1 IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome. Int Immunopharmacol. 2020 Sep;86:106800. doi: 10.1016/j.intimp.2020.106800. Epub 2020 Jul 13.