m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0098)
| Name |
Acute coronary syndrome
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|---|---|---|---|---|---|
| ICD |
ICD-11: BA4Z
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Full List of Target Gene(s) of This m6A-centered Disease Response
hsa_circ_0029589 (Circ_CHFR)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | The relative RNA expression level of hsa_circ_0029589 in macrophages was decreased, whereas the N6-methyladenosine (m6A) level of hsa_circ_0029589 and the expression of m6A methyltransferase METTL3 were validated to be significantly elevated in macrophages in patients with acute coronary syndrome. | |||
| Responsed Disease | Acute coronary syndrome [ICD-11: BA4Z] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| Cell Process | Macrophage pyroptosis | |||
| In-vitro Model | CD14 + cells (CD14+ cells from human peripheral blood) | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 1 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05436 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | hsa_circ_0029589 (Circ_CHFR) | |
| Epigenetic Regulator | hsa_circ_0029589 (Circ_CHFR) | |
| Crosstalk relationship | m6A → ncRNA | |