m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05436
|
[1] | |||
m6A modification
Circ_CHFR
Circ_CHFR
METTL3
Methylation
 : m6A sites
Direct
Inhibition
Non-coding RNA
hsa_circ_0029589
Regulated Target
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | hsa_circ_0029589 (Circ_CHFR) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | hsa_circ_0029589 (Circ_CHFR) | circRNA | View Details | ||
| Crosstalk Relationship | m6A → ncRNA | Inhibition | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | The relative RNA expression level of hsa_circ_0029589 in macrophages was decreased, whereas the N6-methyladenosine (m6A) level of hsa_circ_0029589 and the expression of m6A methyltransferase METTL3 were validated to be significantly elevated in macrophages in patients with acute coronary syndrome. | ||||
| Responsed Disease | Acute coronary syndrome | ICD-11: BA4Z | |||
| Cell Process | Macrophage pyroptosis | ||||
In-vitro Model |
CD14 + cells (CD14+ cells from human peripheral blood) | ||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| BA4Z: Acute coronary syndrome | 1 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
 Compound Name |
MPC-25-IC | Phase 2 | [2] | |
|---|---|---|---|---|
| External Link | ||||
References