m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00047)
Target Name hsa-miR-320b
Synonyms
hsa_miR_320b
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Gene Name hsa-miR-320b
miRBase ID
MIMAT0005792
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-320b can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (miR-186, miR-320c, miR-320d, and hsa-miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features.
Responsed Disease Esophageal cancer ICD-11: 2B70
 Disease Info 
In-vitro Model HEEC cell line (Normal esophageal epithelial cell line)
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary METTL3 could interact with DGCR8 protein and positively modulate pri-miR-320b maturation process in an N6-methyladenosine (m6A)-dependent manner. Therefore, our findings uncover a VEGF-C-independent mechanism of exosomal and intracellular hsa-miR-320b-mediated LN metastasis and identify miR-320b as a novel predictive marker and therapeutic target for LN metastasis in ESCC.
Target Regulation Up regulation
Responsed Disease Esophageal squamous cell carcinoma ICD-11: 2B70.1
 Disease Info 
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process Cell proliferation
Cell migration
Cell invasion
Epithelial-mesenchymal transition
In-vitro Model TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
HET-1A Normal Homo sapiens CVCL_3702
CVCL_E307 Esophageal squamous cell carcinoma Homo sapiens CVCL_E307
Eca-109 Esophageal squamous cell carcinoma Homo sapiens CVCL_6898
In-vivo Model Luciferase-labeled KYSE150 cells (5 × 106) were inoculated into the footpads of BALB/c nude mice (4-5 weeks old, 18-20 g) to establish the popliteal lymphatic metastasis model.
Esophageal cancer [ICD-11: 2B70]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (miR-186, miR-320c, miR-320d, and hsa-miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features.
Responsed Disease Esophageal cancer [ICD-11: 2B70]
Target Regulator Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) READER
 Regulator Info 
In-vitro Model HEEC cell line (Normal esophageal epithelial cell line)
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
Oral cavity/oesophagus/stomach in situ carcinoma [ICD-11: 2E60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [2]
Response Summary METTL3 could interact with DGCR8 protein and positively modulate pri-miR-320b maturation process in an N6-methyladenosine (m6A)-dependent manner. Therefore, our findings uncover a VEGF-C-independent mechanism of exosomal and intracellular hsa-miR-320b-mediated LN metastasis and identify miR-320b as a novel predictive marker and therapeutic target for LN metastasis in ESCC.
Responsed Disease Esophageal squamous cell carcinoma [ICD-11: 2B70.1]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process Cell proliferation
Cell migration
Cell invasion
Epithelial-mesenchymal transition
In-vitro Model TE-1 Esophageal squamous cell carcinoma Homo sapiens CVCL_1759
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens CVCL_1351
KYSE-150 Esophageal squamous cell carcinoma Homo sapiens CVCL_1348
HET-1A Normal Homo sapiens CVCL_3702
CVCL_E307 Esophageal squamous cell carcinoma Homo sapiens CVCL_E307
Eca-109 Esophageal squamous cell carcinoma Homo sapiens CVCL_6898
In-vivo Model Luciferase-labeled KYSE150 cells (5 × 106) were inoculated into the footpads of BALB/c nude mice (4-5 weeks old, 18-20 g) to establish the popliteal lymphatic metastasis model.
References
Ref 1 Network analysis of miRNA targeting m6A-related genes in patients with esophageal cancer. PeerJ. 2021 Jul 29;9:e11893. doi: 10.7717/peerj.11893. eCollection 2021.
Ref 2 Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma. Mol Ther Oncolytics. 2021 Sep 25;23:163-180. doi: 10.1016/j.omto.2021.09.003. eCollection 2021 Dec 17.