m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00047)
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
hsa-miR-320b
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) [READER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (miR-186, miR-320c, miR-320d, and hsa-miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features. | |||
| Responsed Disease | Esophageal cancer | ICD-11: 2B70 | ||
| In-vitro Model | HEEC cell line (Normal esophageal epithelial cell line) | |||
| KYSE-30 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1351 | |
| TE-1 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1759 | |
Methyltransferase-like 3 (METTL3) [WRITER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [2] | |||
| Response Summary | METTL3 could interact with DGCR8 protein and positively modulate pri-miR-320b maturation process in an N6-methyladenosine (m6A)-dependent manner. Therefore, our findings uncover a VEGF-C-independent mechanism of exosomal and intracellular hsa-miR-320b-mediated LN metastasis and identify miR-320b as a novel predictive marker and therapeutic target for LN metastasis in ESCC. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Esophageal squamous cell carcinoma | ICD-11: 2B70.1 | ||
| Pathway Response | PI3K-Akt signaling pathway | hsa04151 | ||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| Epithelial-mesenchymal transition | ||||
| In-vitro Model | TE-1 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1759 |
| KYSE-30 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1351 | |
| KYSE-150 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1348 | |
| HET-1A | Normal | Homo sapiens | CVCL_3702 | |
| CVCL_E307 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_E307 | |
| Eca-109 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_6898 | |
| In-vivo Model | Luciferase-labeled KYSE150 cells (5 × 106) were inoculated into the footpads of BALB/c nude mice (4-5 weeks old, 18-20 g) to establish the popliteal lymphatic metastasis model. | |||
Esophageal cancer [ICD-11: 2B70]
| In total 2 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (miR-186, miR-320c, miR-320d, and hsa-miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features. | |||
| Responsed Disease | Esophageal cancer [ICD-11: 2B70] | |||
| Target Regulator | Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) | READER | ||
| In-vitro Model | HEEC cell line (Normal esophageal epithelial cell line) | |||
| KYSE-30 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1351 | |
| TE-1 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1759 | |
| Experiment 2 Reporting the m6A-centered Disease Response | [2] | |||
| Response Summary | METTL3 could interact with DGCR8 protein and positively modulate pri-miR-320b maturation process in an N6-methyladenosine (m6A)-dependent manner. Therefore, our findings uncover a VEGF-C-independent mechanism of exosomal and intracellular hsa-miR-320b-mediated LN metastasis and identify miR-320b as a novel predictive marker and therapeutic target for LN metastasis in ESCC. | |||
| Responsed Disease | Esophageal squamous cell carcinoma [ICD-11: 2B70.1] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | PI3K-Akt signaling pathway | hsa04151 | ||
| Cell Process | Cell proliferation | |||
| Cell migration | ||||
| Cell invasion | ||||
| Epithelial-mesenchymal transition | ||||
| In-vitro Model | TE-1 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1759 |
| KYSE-30 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1351 | |
| KYSE-150 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_1348 | |
| HET-1A | Normal | Homo sapiens | CVCL_3702 | |
| CVCL_E307 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_E307 | |
| Eca-109 | Esophageal squamous cell carcinoma | Homo sapiens | CVCL_6898 | |
| In-vivo Model | Luciferase-labeled KYSE150 cells (5 × 106) were inoculated into the footpads of BALB/c nude mice (4-5 weeks old, 18-20 g) to establish the popliteal lymphatic metastasis model. | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
Histone modification
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT03375 | ||
| Regulated Target | Histone H3 lysine 18 lactylation (H3K18la) | |
| Crosstalk relationship | Histone modification → m6A | |
| Disease | Esophageal Squamous Cell Carcinoma | |
Non-coding RNA
m6A Regulator: Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05509 | ||
| Epigenetic Regulator | hsa-miR-320b | |
| Regulated Target | Heterogeneous nuclear ribonucleoprotein C (HNRNPC) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Esophageal cancer | |
m6A Regulator: Methyltransferase-like 3 (METTL3)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05635 | ||
| Epigenetic Regulator | hsa-miR-320b | |
| Regulated Target | Programmed cell death 4 (PDCD4) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Esophageal Squamous Cell Carcinoma | |
References