m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00019)
Target Name PncRNA-D
Gene Name PncRNA-D
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
PncRNA-D can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction.
Target Regulation Down regulation
Responsed Disease Liposarcoma ICD-11: 2B59
 Disease Info 
Pathway Response Cell cycle hsa04110
Cell Process Cell cycle
In-vitro Model HAP1 Chronic myelogenous leukemia Homo sapiens CVCL_Y019
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
In-vivo Model ,
YTH domain-containing protein 1 (YTHDC1) [READER]
 Regulator Info 
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction.
Target Regulation Down regulation
Responsed Disease Liposarcoma ICD-11: 2B59
 Disease Info 
Pathway Response Cell cycle hsa04110
Cell Process Cell cycle
In-vitro Model HAP1 Chronic myelogenous leukemia Homo sapiens CVCL_Y019
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
In-vivo Model ,
Liposarcoma [ICD-11: 2B59]
 Disease Info 
In total 2 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction.
Responsed Disease Liposarcoma [ICD-11: 2B59]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cell cycle hsa04110
Cell Process Cell cycle
In-vitro Model HAP1 Chronic myelogenous leukemia Homo sapiens CVCL_Y019
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
In-vivo Model ,
Experiment 2 Reporting the m6A-centered Disease Response [1]
Response Summary Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction.
Responsed Disease Liposarcoma [ICD-11: 2B59]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cell cycle hsa04110
Cell Process Cell cycle
In-vitro Model HAP1 Chronic myelogenous leukemia Homo sapiens CVCL_Y019
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
In-vivo Model ,
Motor neuron disease [ICD-11: 8B60]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response []
Response Summary Translocated in LipoSarcoma/Fused in Sarcoma (TLS/FUS) is a nuclear RNA binding protein whose mutations cause amyotrophic lateral sclerosis. The binding specificity of TLS/FUS to short RNA fragments derived from PncRNA-D, both wild type and ALS-related TLS/FUS mutants demonstrated stronger binding to m6A-modified RNA fragments.
Responsed Disease Amyotrophic lateral sclerosis [ICD-11: 8B60.0]
In-vitro Model HAP1 Chronic myelogenous leukemia Homo sapiens CVCL_Y019
References
Ref 1 Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification. J Biol Chem. 2020 Apr 24;295(17):5626-5639. doi: 10.1074/jbc.RA119.011556. Epub 2020 Mar 12.