m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0052)
| Name |
Liposarcoma
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|---|---|---|---|---|---|
| ICD |
ICD-11: 2B59
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Full List of Target Gene(s) of This m6A-centered Disease Response
PncRNA-D
| In total 2 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction. | |||
| Responsed Disease | Liposarcoma [ICD-11: 2B59] | |||
| Target Regulator | YTH domain-containing protein 1 (YTHDC1) | READER | ||
| Target Regulation | Down regulation | |||
| Pathway Response | Cell cycle | hsa04110 | ||
| Cell Process | Cell cycle | |||
| In-vitro Model | HAP1 | Chronic myelogenous leukemia | Homo sapiens | CVCL_Y019 |
| HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |
| Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [1] | |||
| Response Summary | Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction. | |||
| Responsed Disease | Liposarcoma [ICD-11: 2B59] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Down regulation | |||
| Pathway Response | Cell cycle | hsa04110 | ||
| Cell Process | Cell cycle | |||
| In-vitro Model | HAP1 | Chronic myelogenous leukemia | Homo sapiens | CVCL_Y019 |
| HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 2 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05422 | ||
| m6A Regulator | YTH domain-containing protein 1 (YTHDC1) | |
| m6A Target | PncRNA-D | |
| Epigenetic Regulator | PncRNA-D | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05423 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | PncRNA-D | |
| Epigenetic Regulator | PncRNA-D | |
| Regulated Target | G1/S-specific cyclin-D1 (CCND1) | |
| Crosstalk relationship | m6A → ncRNA | |