m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0052)
Name
Liposarcoma
ICD
ICD-11: 2B59
Full List of Target Gene(s) of This m6A-centered Disease Response
PncRNA-D
 Target Info 
In total 2 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction.
Responsed Disease Liposarcoma [ICD-11: 2B59]
Target Regulator YTH domain-containing protein 1 (YTHDC1) READER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cell cycle hsa04110
Cell Process Cell cycle
In-vitro Model HAP1 Chronic myelogenous leukemia Homo sapiens CVCL_Y019
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
In-vivo Model ,
Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene [1]
Response Summary Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction.
Responsed Disease Liposarcoma [ICD-11: 2B59]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Down regulation
Pathway Response Cell cycle hsa04110
Cell Process Cell cycle
In-vitro Model HAP1 Chronic myelogenous leukemia Homo sapiens CVCL_Y019
HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
In-vivo Model ,
References
Ref 1 Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification. J Biol Chem. 2020 Apr 24;295(17):5626-5639. doi: 10.1074/jbc.RA119.011556. Epub 2020 Mar 12.