General Information of the Disease (ID: M6ADIS0307)
Name
T(8;21) acute myeloid leukemia
ICD
ICD-11: XH3CX5
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 2 item(s) under this disease
Crosstalk ID: M6ACROT03224
m6A Regulator Wilms tumor 1-associating protein (WTAP)
m6A Target PHD finger protein 19 (PHF19)
Epigenetic Regulator Polycomb Repressive Complex 2 (PRC2)
Regulated Target Histone H3 lysine 27 trimethylation (H3K27me3)
Crosstalk relationship m6A → Histone modification
Crosstalk ID: M6ACROT03227
m6A Regulator Wilms tumor 1-associating protein (WTAP)
m6A Target Lysine-specific demethylase 4B (KDM4B)
Epigenetic Regulator Lysine-specific demethylase 4B (KDM4B)
Crosstalk relationship m6A → Histone modification
References
Ref 1 A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma. Oncol Res. 2020 Sep 1;28(4):331-344. doi: 10.3727/096504020X15825405463920. Epub 2020 Feb 24.
Ref 2 WL-276, an antagonist against Bcl-2 proteins, overcomes drug resistance and suppresses prostate tumor growth. Cancer Res. 2008 Jun 1;68(11):4377-83. doi: 10.1158/0008-5472.CAN-07-6590.